Protein Alignment polybromo and SNF2

DIOPT Version :10

• Sequence 1: NP_651288.1
• Gene: polybromo / 42954
• FlyBaseID: FBgn0039227
• Length: 1654
• Species: Drosophila melanogaster
• Sequence 2: NP_014933.3
• Gene: SNF2 / 854465
• SGDID: S000005816
• Length: 1703
• Species: Saccharomyces cerevisiae
• Alignment Length: 761
• Identity: 168/761 - (22%)
• Similarity: 274/761 - (36%)
• Gaps: 218/761 - (28%)

  Fly    28 EQSPVQQTTTQSARKKRRLDPTELCQQLYDSIRNIKKEDGSM-LCDTFIRVPKRRQEPSYYDVV- 90
            :.|.:||...|...|.||         |:...:|.||..|.. ..:..:::.|....|..::.|
Yeast  1014 KMSALQQIMYQQMLKYRR---------LFIGDQNNKKMVGLRGFNNQIMQLKKICNHPFVFEEVE 1069

  Fly    91 --VNP--------------IDLL-KVQQKLKTDSY--------DDLDDLMADLELLIGNAKAFYI 130
              :||              .:|| ::..|||...:        ..:.|:|.|....| |.|...:
Yeast  1070 DQINPTRETNDDIWRVAGKFELLDRILPKLKATGHRVLIFFQMTQIMDIMEDFLRYI-NIKYLRL 1133

  Fly   131 PGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDGAT------- 188
            .|.::..:        .|:..|:..|       |.:..:.     ...||..||.|..
Yeast  1134 DGHTKSDE--------RSELLRLFNA-------PDSEYLC-----FILSTRAGGLGLNLQTADTV 1178

  Fly   189 ---DDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPID-LRLIATK--- 246
               |.::|.:::|.|.         || .||:.|               ::.:. ||||.|.
Yeast  1179 IIFDTDWNPHQDLQAQ---------DR-AHRIGQ---------------KNEVRILRLITTNSVE 1218

  Fly   247 --IQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDA--KSLKRIFTQRRIELEMGKGKLAKR 307
              |...||..| :::..::|..|    |:...:...::|  :||.....:||.:.|.|..:..:.
Yeast  1219 EVILERAYKKL-DIDGKVIQAGK----FDNKSTSEEQEALLRSLLDAEEERRKKRESGVEEEEEL 1278

  Fly   308 VKSLSSAAIAALKEE--VDSSDDEETSKKGE--GPMWALFDH----------------------- 345
            ..|..:..:|...||  |.:..||:.|||.|  |....|.:.
Yeast  1279 KDSEINEILARNDEEMAVLTRMDEDRSKKEEELGVKSRLLEKSELPDIYSRDIGAELKREESESA 1343

  Fly   346 -LYNAPGTSEHPGVT-GPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLK----------- 397
             :||..|..|....| ...:....|   :|:|  |..:..|......:..||.:
Yeast  1344 AVYNGRGARERKTATYNDNMSEEQW---LRQF--EVSDDEKNDKQARKQRTKKEDKSEAIDGNGE 1403

  Fly   398 -KG-------DYANISDLTA------DLYL----MLDNAKKAFPTSHRTHKDALKMLKLMNAKLV 444
             ||       |...|::::|      ||.:    .|...:||.....|..|..|:..:......:
Yeast  1404 IKGENIDADNDGPRINNISAEDRADTDLAMNDDDFLSKKRKAGRPRGRPKKVKLEGSENSEPPAL 1468

  Fly   445 EESLEEGSDLDDEDAEEM-------DTEVFTVSTQPEKRKPGRPRINSNSNSNAS---------- 492
            |.|...|.:...||..::       .|.|.:..|....|..||.|..........
Yeast  1469 ESSPVTGDNSPSEDFMDIPKPRTAGKTSVKSARTSTRGRGRGRGRGRGRGRGRGRPPKARNGLDY 1533

  Fly   493 -HTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDY-SLGNRRPIEMFMEKPPRKIYPDYYDIIQN 555
             .||..:.||    |.|...:.|:.|.:..:.::| :...|:..::|:.||.:.:|||||.||:.
Yeast  1534 VRTPAAATSP----IDIREKVAKQALDLYHFALNYENEAGRKLSDIFLSKPSKALYPDYYMIIKY 1594

  Fly   556 PIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLT 620
            |:..:.|..:|.|..|.::::.:.|:.|:|||.|.||.|||.:|||:..||:.:.:|..|.
Yeast  1595 PVAFDNINTHIETLAYNSLKETLQDFHLIFSNARIYNTEGSVVYEDSLELEKVVTKKYCEI---- 1655

  Fly   621 EGKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEPKGKRQLSL 666
            .|..||..::                       |:.|..|.|.|.|
Yeast  1656 MGDNSQLDFT-----------------------EFDEQYGTRPLVL 1678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:445827	25/138 (18%)
		Bromo_polybromo_II	191..294	CDD:99948	23/110 (21%)
		Bromo_polybromo_III	335..443	CDD:99951	28/163 (17%)
		Bromo_polybromo_IV	512..613	CDD:99949	35/101 (35%)
		Bromo_polybromo_V	641..733	CDD:99946	6/26 (23%)
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box_PB1	1319..1376	CDD:438800
SNF2	NP_014933.3	QLQ	248..281	CDD:462622
		HSA	<617..656	CDD:462194
		PLN03142	650..>1297	CDD:215601	70/342 (20%)
		SnAC	1303..1369	CDD:464219	12/68 (18%)
		Bromo_SNF2	1550..1652	CDD:99950	35/101 (35%)