Protein Alignment polybromo and RSC4

DIOPT Version :10

• Sequence 1: NP_651288.1
• Gene: polybromo / 42954
• FlyBaseID: FBgn0039227
• Length: 1654
• Species: Drosophila melanogaster
• Sequence 2: NP_012933.4
• Gene: RSC4 / 853877
• SGDID: S000001716
• Length: 625
• Species: Saccharomyces cerevisiae
• Alignment Length: 706
• Identity: 157/706 - (22%)
• Similarity: 253/706 - (35%)
• Gaps: 190/706 - (26%)

  Fly   470 STQPEKRKPGRPRINSNSNSNASH-TPNNSNS---------PKSNRIAINAAIKKKILSIQKYLV 524
            |.:..|..||:...|.....:..: .|.|..|         ||.||..             .:.:
Yeast    15 SDERPKYLPGKHPKNQEKTPHVDYNAPLNPKSELFLDDWHIPKFNRFI-------------SFTL 66

  Fly   525 DYSLGNRRPI-EMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVS----DYRLM 584
            |..:...:.| :.|::.|.||.:|.||..||.|:.:|.|:     .|....||..|    |..|:
Yeast    67 DVLIDKYKDIFKDFIKLPSRKFHPQYYYKIQQPMSINEIK-----SRDYEYEDGPSNFLLDVELL 126

  Fly   585 FSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKY---SKVGRKL-----KTAVI 641
            ..||:.|||..|.|.:  |.::..:   |.||..| :.|..::.|   |:|..||     |....
Yeast   127 TKNCQAYNEYDSLIVK--NSMQVVM---LIEFEVL-KAKNLKRNYLINSEVKAKLLHYLNKLVDA 185

  Fly   642 TERLWQFYETVKEYQEPKG---KRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYD 703
            ||:  :..:.:.....||.   |.:||..|.:|..|.|.|:||:|:..|:.:..:.|.|:.|.|.
Yeast   186 TEK--KINQALLGASSPKNLDDKVKLSEPFMELVDKDELPEYYEIVHSPMALSIVKQNLEIGQYS 248

  Fly   704 TLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTL 768
            .:.|...|.||:.:||..:|:|.:.|||||                                 |.
Yeast   249 KIYDFIIDMLLVFQNAHIFNDPSALIYKDA---------------------------------TT 280

  Fly   769 FTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACL 833
            .|..:|:..::     :...||.:.:|.||      |:|:.
Yeast   281 LTNYFNYLIQK-----EFFPELQDLNERGE------INLEF------------------------ 310

  Fly   834 ERARKLSRTDSDIFQDSIELQTYF-IRKRDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEE 897
                           |..|.:.|. |..........|:.|||:..:|     .|..|:..:.|.:
Yeast   311 ---------------DKFEFENYLAIGGGGPAAAGALAISALDNDIE-----PESNREDLIDQAD 355

  Fly   898 QDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASI 962
            .|         ||..:|.....|:.:.:..   |:..|.|....|...|.:.:...||:...:.|
Yeast   356 YD---------FNHFEGLGNGYNRSLLTED---YLLNPNNFKKLIAKPETVQSEVKNERSTTSDI 408

  Fly   963 -FVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCES 1026
             .....|:.|:...|:   .|.||...:..|:.:...|.|          :|..|.:: :|:..|
Yeast   409 EKTNSLESEHLKIPKY---NVIKSMQKEMQSLSEQHTMEY----------KPYKLIQQ-IYIFSS 459

  Fly  1027 RYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGEL-------EELKL 1084
            : |:..:..|.|....|....:.|:::....  ||.:..:.|...|:..:..|       ..||.
Yeast   460 K-NLYSQATKPLLGSRPSCNQNWVEYIFNGN--ELSQNENAFSFMLQPMQTFLTLQSHLTSSLKD 521

  Fly  1085 QETL--VEKE-------KPNVSCDPPPNAE---VGSTYYQQYNTICSGAIKTGDFV 1128
            .|||  :.||       ..|.:...|...|   :|:...|....:..|.....|.|
Yeast   522 TETLLTINKEPVKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIV 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:445827
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951
		Bromo_polybromo_IV	512..613	CDD:99949	28/105 (27%)
		Bromo_polybromo_V	641..733	CDD:99946	31/94 (33%)
		Bromo_polybromo_VI	758..867	CDD:99956	14/109 (13%)
		BAH_polybromo	921..1040	CDD:240068	24/119 (20%)
		BAH_polybromo	1120..1234	CDD:240068	3/9 (33%)
		HMG-box_PB1	1319..1376	CDD:438800
RSC4	NP_012933.4	COG5076	40..423	CDD:227408	116/508 (23%)