DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and RSC1

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_011570.1	Gene:	RSC1 / 852947	SGDID:	S000003288	Length:	928	Species:	Saccharomyces cerevisiae

Alignment Length:	1043	Identity:	219/1043 - (20%)
Similarity:	377/1043 - (36%)	Gaps:	309/1043 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 KKILSIQKYLVDYSLGNRRPIE---MFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVE 575
            :|:|..| |...:.|.:...||   :|...||:|.|||||.||:|||.:||::.  |...|.:.:
Yeast    10 QKLLKTQ-YDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKK--RLPHYTSPQ 71

  Fly   576 DVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKL-----KEFPGLTEGKKSQQKYSKVGRK 635
            |.|:|:..:..|...||.:.|.||:.|.:||..:..|:     |.:|.:|        |..:||
Yeast    72 DFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKIVHNIRKHYPEVT--------YPSLGR- 127

  Fly   636 LKTAVITERLWQFYETV------------KEYQEPKG-KRQLSLIFTKLPSK-SEYPDYYDIIRE 686
                 |.|   .|.|::            :|..|..| ..::.:.|.||.|. :|        |:
Yeast   128 -----IPE---IFAESMQPSDLSSNPINTQENDEKAGLNPEMKMAFAKLDSSITE--------RK 176

  Fly   687 PIDMD-RIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQL----------- 739
            |.:.| |:.||                          |.|....:..::..|.|
Yeast   177 PTNQDYRMQQK--------------------------NSPAFPTHSASITPQPLASPTPVVNYAN 215

  Fly   740 --TLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKV 802
              :...|..:|..|..:.|:|..::  ...:...:....|:..:..:....:||:.:   |.|..
Yeast   216 ITSAHPKTHVRRGRPPVIDLPYVLR--IKNILKMMRREVDQNNKTLTLCFEKLPDRN---EEPTY 275

  Fly   803 RGISLDL-----VKRRLDKGAYKRLDVYQEDIFACLERARKL--SRTDSDIFQDSIELQTYFIR- 859
            ..:..|.     :::::....|:....::|| |..:....||  |:..|:|.:..: |:..|.|
Yeast   276 YSVITDPICLMDIRKKVKSRKYRNFHTFEED-FQLMLTNFKLYYSQDQSNIIRAQL-LEKNFNRL 338

  Fly   860 KRDELCK---DTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQ 921
            .|.||.|   |.|....|.:.|:    |||                                ||.
Yeast   339 VRIELSKPDEDYLPEGELRYPLD----DVE--------------------------------IND 367

  Fly   922 QVFSPGDYVYVQMPE--NKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFK 984
            :.:..||:|.:..|.  || |.:..|.|||::....|.:.|..:.||.:|.|...|.|.:.||.|
Yeast   368 EKYQIGDWVLLHNPNDINK-PIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVDRLFYKNEVMK 431

  Fly   985 SSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSW-------- 1041
            :...:...:..::|.|||::...:.:..|........:|||.|||...:.|.|:::|
Yeast   432 TGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTKVNGPQFVCEFRYNESDKVFNKIRTWKACLPEEL 496

  Fly  1042 ----PPVREGSSVKFVPREQPL-ELKRVMSVFKERL-EKHKG---------------ELEELKLQ 1085
                .|....:..||.....|: :|....:...::: |..:|               :||...|.
Yeast   497 RDQDEPTIPVNGRKFFKYPSPIADLLPANATLNDKVPEPTEGAPTAPPLVGAVYLGPKLERDDLG 561

  Fly  1086 ETLVEKE------KPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQ--SVAQV 1142
            |.....:      :||   |||   |.|...|:. .||.:..:.|.....|.:.:..:  ::.|.
Yeast   562 EYSTSDDCPRYIIRPN---DPP---EEGKIDYET-GTIITDTLTTSSMPRVNSSSTIRLPTLKQT 619

  Fly  1143 QQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYRQE--LLLSTVEEVS------PVVGIVGRCAVL 1199
            :.|...|.:|          |..||.|.:.|.:..  |.|..:...|      |.|......::|
Yeast   620 KSIPSSNFRS----------SSNTPLLHQNFNQTSNFLKLENMNNSSHNLLSHPSVPKFQSPSLL 674

  Fly  1200 EYSE----FISSRPTEISE-------SDVYICESVYDEL-------------------------- 1227
            |.|.    ..:.:.|::|.       |..:...|:.:.|
Yeast   675 EQSSRSKYHSAKKQTQLSSTAPKKPASKSFTLSSMINTLTAHTSKYNFNHIVIEAPGAFVVPVPM 739

  Fly  1228 KKALRKLVT------GNMRKFQ-------HSPSVTEDEIFYFKTP--------IKPSKDF----- 1266
            :|.:|.:.:      .|::..|       :..:...::|.:||.|        |....|.
Yeast   740 EKNIRTIQSTERFSRSNLKNAQNLGNTAINDINTANEQIIWFKGPGVKITERVIDSGNDLVRVPL 804

  Fly  1267 -----KNELNEL---GMLEDSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGY 1323
                 ||:..:|   .:.||.|:.........||.:.:|.||:|   |...:..:.|
Yeast   805 NRWFCKNKRRKLDYEDIEEDVMEPPNDFSEDMIANIFNPPPSLN---LDMDLNLSPS-------- 858

  Fly  1324 ILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWEDRASRQNEETAALRRELDDVQN 1388
                         ||..:.|.|:|.:...:.........:..||    :||:|.. ..|::|:..
Yeast   859 -------------SNNSSNFMDLSTIASGDNDGKECDTAEESED----ENEDTED-EHEIEDIPT 905

  Fly  1389 SAS 1391
            :::
Yeast   906 TSA 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951
		Bromo_polybromo_IV	512..613	CDD:99949	37/101 (37%)
		Bromo_polybromo_V	641..733	CDD:99946	20/106 (19%)
		Bromo_polybromo_VI	758..867	CDD:99956	23/119 (19%)
		BAH_polybromo	921..1040	CDD:240068	35/120 (29%)
		BAH_polybromo	1120..1234	CDD:240068	26/160 (16%)
		HMG-box	1320..1375	CDD:238037	8/54 (15%)
RSC1	NP_011570.1	Bromo_Rsc1_2_I	8..113	CDD:99952	38/105 (36%)
RSC1	NP_011570.1	COG5076	115..463	CDD:227408	91/442 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I2482
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.959148	Normalized mean entropy	S4369
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002672
OrthoInspector	1	1.000	-	-		otm46821
orthoMCL	1	0.900	-	-		OOG6_103614
Panther	1	1.100	-	-	O	PTHR16062
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11130
SonicParanoid	1	1.000	-	-		X2912
TreeFam	0	0.000	Not matched by this tool.
	9	8.880