DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and BDF1

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_013503.1	Gene:	BDF1 / 851115	SGDID:	S000004391	Length:	686	Species:	Saccharomyces cerevisiae

Alignment Length:	697	Identity:	144/697 - (20%)
Similarity:	248/697 - (35%)	Gaps:	213/697 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 IKRPISM---------------SQIHTKLKKGDYANISDLTADL-------YLMLDNAKKAFPTS 425
            :||||..               :|:|.|..:.|...::...|.|       ..:..|.:..:..:
Yeast    26 LKRPIDQGDPSNGLAEEENPANNQLHLKKARLDGDALTSSPAGLAENGIEGATLAANGENGYNAT 90

  Fly   426 HRTHKDALKMLKLMNAKLVEESLEEG------SDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRIN 484
            ....:|..:.||          .|||      .|||:...:|:..|   |..:|....|..|.:|
Yeast    91 GSGAEDEQQGLK----------KEEGGQGTKQEDLDENSKQELPME---VPKEPAPAPPPEPDMN 142

  Fly   485 SNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDY 549
                 |....|...:..|...:||.|.  |::...:.:|        :|::     |.:...|.|
Yeast   143 -----NLPQNPIPKHQQKHALLAIKAV--KRLKDARPFL--------QPVD-----PVKLDIPFY 187

  Fly   550 YDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLK 614
            ::.|:.|:|::|||..:....|...|.:..|:.||.:|..::|...:.|.:.|..::.:..:.:.
Yeast   188 FNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNGPNAGISQMARNIQASFEKHML 252

  Fly   615 EFPG------LTEGKKS--QQKYSKVGRKLKT-------AVITERLWQFYETVKEYQEPKGKR-Q 663
            ..|.      :.:|::|  |:....|.|:.:|       .:...:....|.  .|.::||.|| |
Yeast   253 NMPAKDAPPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRTIHPPKSKDIYP--YESKKPKSKRLQ 315

  Fly   664 LSLIFTKL----------------------PSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLD 706
            .::.|.:.                      |.....|.|:|.::||:|:..||:||....|.|::
Yeast   316 QAMKFCQSVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLGTIAKKLNDWQYQTME 380

  Fly   707 DLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRT---ERDSLPDVPLAVQELFLTL 768
            |...|..|:.:|...:|       .|..::..:..:|::...:   :|.:|.|
Yeast   381 DFERDVRLVFKNCYTFN-------PDGTIVNMMGHRLEEVFNSKWADRPNLDD------------ 426

  Fly   769 FTTIYNHQDEEGRC---YSDSLAELPEYD---EIGEGPKVRGISLDLVK---------------- 811
                |: .||:.|.   |.|..:|..|.|   .|...|.::.:...|.:
Yeast   427 ----YD-SDEDSRTQGDYDDYESEYSESDIDETIITNPAIQYLEEQLARMKVELQQLKKQELEKI 486

  Fly   812 ---RRLDKGAYKR-------------------------LDVYQEDIFACL-ERARKLSRTDSDIF 847
               |||.:|:.||                         ..|...|:...: ||...|..:..:..
Yeast   487 RKERRLARGSKKRGKRSKGRSGSKNASSKGRRDKKNKLKTVVTYDMKRIITERINDLPTSKLERA 551

  Fly   848 QDSIELQTYFIRKRD--ELCKDTL------------------SSSALN------------FSLER 880
            .|.|:.....|.:.|  ||..|||                  ||.|.|            .||..
Yeast   552 IDIIKKSMPNISEDDEVELDLDTLDNHTILTLYNTFFRQYESSSGASNGLDGTSGVTRDASSLSP 616

  Fly   881 LMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPG 927
            ..|.....|.:.:.||||.::.:|.|::.  |..:|.:...|..|||
Yeast   617 TSAGSRKRRSKALSQEEQSRQIEKIKNKL--AILDSASPLSQNGSPG 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951	14/81 (17%)
		Bromo_polybromo_IV	512..613	CDD:99949	21/100 (21%)
		Bromo_polybromo_V	641..733	CDD:99946	26/114 (23%)
		Bromo_polybromo_VI	758..867	CDD:99956	29/161 (18%)
		BAH_polybromo	921..1040	CDD:240068	4/7 (57%)
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	80/381 (21%)
		Bromodomain	<339..417	CDD:413371	20/84 (24%)
		PTZ00108	<386..647	CDD:240271	54/286 (19%)
		BET	527..589	CDD:407211	14/61 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810