DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and RSC2

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_013461.1	Gene:	RSC2 / 851071	SGDID:	S000004349	Length:	889	Species:	Saccharomyces cerevisiae

Alignment Length:	970	Identity:	199/970 - (20%)
Similarity:	344/970 - (35%)	Gaps:	273/970 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 NNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIE---MFMEKPPRKIYPDYYDIIQNPI 557
            :||||...|..|:...::|:..|:      ::|.....:|   :|...||:|.|||||.:|:||:
Yeast     5 DNSNSSTQNSSALYKDLRKEYESL------FTLKEDSGLEISPIFNVLPPKKDYPDYYAVIKNPV 63

  Fly   558 DMNTIEHNI--RTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNE----KLKE- 615
            ..||::..|  .||....:.|||.    :..|.:.||...|.||:.|.:||:.|.:    .|||
Yeast    64 SFNTLKKRIPHYTDAQQFMNDVVQ----IPWNAKTYNTRDSGIYKYALVLEKYLKDTIYPNLKEK 124

  Fly   616 --------------FPGLTE-GKKSQQKYSKVGR----------KLKTAVITERLWQFYETVKEY 655
                          .||..| .:|.::|..:|.|          .:.:.....||.:...:||..
Yeast   125 YPQLVYPDLGPLPDEPGYEEFQQKLREKAEEVARANAARAESSSSMNSTEAARRLRKTRTSVKRE 189

  Fly   656 QEPKGKRQLSLIFTKLPSKSEY------------PDYYDIIREP-IDMDRIAQK-LKQGAYDTLD 706
            .||.         |...:..:|            .|:.|:||:| |:::...:| |:.....|..
Yeast   190 SEPG---------TDTNNDEDYEATDMDIDNPKDADFPDLIRKPLININPYTRKPLRDNRSTTPS 245

  Fly   707 DLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTE--RDSLPDVPLAVQELFLTLF 769
            .....                         |.|..:.:|..||:  |...|.:.|...:....:.
Yeast   246 HSGTP-------------------------QPLGPRHRQVSRTQVKRGRPPIIDLPYIQRMKNVM 285

  Fly   770 TTIYNHQDEEGRCYSDSLAELPE------YDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQED 828
            ..:.....:.|...:|....||:      |..:...|    |||..:.:::....||....:|.|
Yeast   286 KVLKKEVLDSGIGLTDLFERLPDRHRDANYYIMIANP----ISLQDINKKVKTRRYKTFQEFQND 346

  Fly   829 IFACLERARKLSRTDSDIFQDSIELQ-TYFIRKRDELCKDTLS---SSALNFSLERLMADVELCR 889
            ....|...|...|.|.:..:.|..|: |:....|.||.|...|   ...|.:.|:.::
Yeast   347 FNLMLTNFRISHRGDPESIKISNILEKTFTSLARFELSKPDRSFIPEGELRYPLDEVI------- 404

  Fly   890 QQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQ-MPENKIPSICCIERLWTSPT 953
                                         :|...:..||:..:: ..:.:.|.:..|.|||.:|.
Yeast   405 -----------------------------VNNISYHVGDWALLRNQNDPQKPIVGQIFRLWKTPD 440

  Fly   954 NEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPE 1018
            .::.:.|..:.||.:|.|...|.|.:.||.|:...:...:..:.|.|||::...|.:..|:...|
Yeast   441 GKQWLNACWYYRPEQTVHRVDRLFYKNEVMKTGQYRDHLVSNLVGKCYVIHFTRYQRGNPDMKLE 505

  Fly  1019 KDVYVCESRYNIQGRWFKKLKSW---------------------------PPVREGSSVKFVPRE 1056
            ..::|||.|||...:.|.|:::|                           .|:|........|.:
Yeast   506 GPLFVCEFRYNESDKIFNKIRTWKACLPEEIRDLDEATIPVNGRKFFKYPSPIRHLLPANATPHD 570

  Fly  1057 Q------------PLELKRVMSVFKERLEKHKGELEELKLQETLVEKEKPNVSCDPPPNAEVGST 1109
            :            ||    |.:|:.      :.:::...|.|.....:.|.....|..:.|.|..
Yeast   571 RVPEPTMGSPDAPPL----VGAVYM------RPKMQRDDLGEYATSDDCPRYIIRPNDSPEEGQV 625

  Fly  1110 YYQ----QYNTICSGAI-KTGDFVYVATQ-------------TGKQSVAQVQQIWEQNGKSYFKG 1156
            ..:    ..||..:.|: |||   |.:::             ..:.::.|.|....:.|.....|
Yeast   626 DIETGTITTNTPTANALPKTG---YSSSKLSSLRYNRSSMSLENQNAIGQQQIPLSRVGSPGAGG 687

  Fly  1157 PWLLPPSETTPGLGK-----------QFYRQELLLSTVEEVSPVV---------GIVGRCAVLEY 1201
            |.      |..||.:           |:.:|:...::...:..::         |.:|...:...
Yeast   688 PL------TVQGLKQHQLQRLQQQQHQYQQQKRSQASRYNIPTIIDDLTSQASRGNLGNIMIDAA 746

  Fly  1202 SEFISSRPTEISES-DVYICESVYDELKKALR------KLVTGNMRKFQHSPSVTEDEIF----- 1254
            |.|:  .|..|::: ||.....::.:.|::.|      |...|.:..|: .|||..:|..
Yeast   747 SSFV--LPISITKNVDVLQRTDLHSQTKRSGREEMFPWKKTKGEILWFR-GPSVIVNERIINSGD 808

  Fly  1255 ---------YFKTPIKPSKDFKNELNELGMLED--SMDGDTPSLSSDI--AAMSSPAPSV 1301
                     :|.|..|...::: |:.|  .:||  ..|.|...|..|:  ...|.|.|.|
Yeast   809 PHLSLPLNRWFTTNKKRKLEYE-EVEE--TMEDVTGKDKDDDGLEPDVENEKESLPGPFV 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951
		Bromo_polybromo_IV	512..613	CDD:99949	34/109 (31%)
		Bromo_polybromo_V	641..733	CDD:99946	17/105 (16%)
		Bromo_polybromo_VI	758..867	CDD:99956	24/115 (21%)
		BAH_polybromo	921..1040	CDD:240068	33/119 (28%)
		BAH_polybromo	1120..1234	CDD:240068	25/154 (16%)
		HMG-box	1320..1375	CDD:238037
RSC2	NP_013461.1	Bromo_Rsc1_2_I	17..121	CDD:99952	34/113 (30%)
RSC2	NP_013461.1	COG5076	123..503	CDD:227408	85/453 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I2482
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002672
OrthoInspector	1	1.000	-	-		otm46821
orthoMCL	1	0.900	-	-		OOG6_103614
Panther	1	1.100	-	-	LDO	PTHR16062
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11130
SonicParanoid	1	1.000	-	-		X2912
TreeFam	0	0.000	Not matched by this tool.
	8	7.930