DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and BRD3

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_031397.1	Gene:	BRD3 / 8019	HGNCID:	1104	Length:	726	Species:	Homo sapiens

Alignment Length:	940	Identity:	169/940 - (17%)
Similarity:	316/940 - (33%)	Gaps:	338/940 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQ 292
            |||:.:|::|:|:..|..:::.|.|.|.:|..:|...|..|..::|:|...|...|::|::||.|
Human    71 PDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQ 135

  Fly   293 R-----RIELEM------GKG-KLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDH 345
            :     :.|:|:      ||| |.|...:|..:..:||:     ||....|      |..::
Human   136 KVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAV-----SSVSPAT------PFQSV--- 186

  Fly   346 LYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTAD 410
               .|..|:.|.:...|                                         :..:||:
Human   187 ---PPTVSQTPVIAATP-----------------------------------------VPTITAN 207

  Fly   411 LYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEK 475
            :      .....|.:......|..::.::                             ..|.|..
Human   208 V------TSVPVPPAAAPPPPATPIVPVV-----------------------------PPTPPVV 237

  Fly   476 RKPG-RPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFME 539
            :|.| :.:.::.:.:.::.|.:.|.||.    .::...:.|:::.::       ...|||
Human   238 KKKGVKRKADTTTPTTSAITASRSESPP----PLSDPKQAKVVARRE-------SGGRPI----- 286

  Fly   540 KPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANI 604
            |||:|             |:                                        ||..:
Human   287 KPPKK-------------DL----------------------------------------EDGEV 298

  Fly   605 LERALNEKLKEFPGLTEGKKSQQKYSKVGRKLK--TAVITERL--------WQFYETVKEYQEPK 659
            .:.|             |||     .|:...|:  .:::.|.|        |.||:.|.
Human   299 PQHA-------------GKK-----GKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVD------ 339

  Fly   660 GKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNE 724
                        ....|..||:|||:.|:|:..:.:|:....|......|||..||..|..|||.
Human   340 ------------AEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNP 392

  Fly   725 PDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAE 789
            ||.::...|..||.:                                           :....|:
Human   393 PDHEVVAMARKLQDV-------------------------------------------FEMRFAK 414

  Fly   790 LPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQ 854
            :|  ||..|.|.:...:..:|    .|||..             .|:.:.|.:||.......|..
Human   415 MP--DEPVEAPALPAPAAPMV----SKGAES-------------SRSSEESSSDSGSSDSEEERA 460

  Fly   855 TYFIRKRDELCKDTLSSSALNFSLERL-MADVELCRQQKMQQEEQDQEQDKEKD-EFNAAKGESM 917
            |.....:::|       .|::..|..| .|.|...:::|.::|::.:::||||: |.:..|.|..
Human   461 TRLAELQEQL-------KAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEE 518

  Fly   918 TINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLM-----QASIFVRPHETYHVTTRKF 977
            . ..:|..|..    |..:.|.|:    ::..::.|..:.:     |||......|........:
Human   519 K-KAKVAPPAK----QAQQKKAPA----KKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSY 574

  Fly   978 LEKEVFKSSLSQTISMDKVQGMCYVMNIK--------------DYIKMRPENLPEKDVYV--CES 1026
            .||......::: :..:|:..:.:::..:              |:..::|..|.|.:.||  |
Human   575 DEKRQLSLDINR-LPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSC-- 636

  Fly  1027 RYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVEK 1091
               :|.:..|...:....:...|.:.:.:|:..||::       ||:...|:|...|..   ..|
Human   637 ---LQKKQRKPFSASGKKQAAKSKEELAQEKKKELEK-------RLQDVSGQLSSSKKP---ARK 688

  Fly  1092 EKPNVSCDPPPNAEVGSTYYQQYNTICSGA 1121
            |||..:....|:....|:..:..::..||:
Human   689 EKPGSAPSGGPSRLSSSSSSESGSSSSSGS 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	22/70 (31%)
		Bromo_polybromo_III	335..443	CDD:99951	9/107 (8%)
		Bromo_polybromo_IV	512..613	CDD:99949	12/100 (12%)
		Bromo_polybromo_V	641..733	CDD:99946	27/99 (27%)
		Bromo_polybromo_VI	758..867	CDD:99956	17/108 (16%)
		BAH_polybromo	921..1040	CDD:240068	22/139 (16%)
		BAH_polybromo	1120..1234	CDD:240068	1/2 (50%)
		HMG-box	1320..1375	CDD:238037
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Bromo_Brdt_I_like	34..140	CDD:99929	22/68 (32%)
		Acetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:27105114	78..80		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..305		19/149 (13%)
		Bromo_Brdt_II_like	311..412	CDD:99930	31/161 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..462		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..575		23/106 (22%)
		BET	571..635	CDD:293640	9/64 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..726		19/92 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900