DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment polybromo and BRDT

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_001229735.2 Gene:BRDT / 676 HGNCID:1105 Length:951 Species:Homo sapiens


Alignment Length:1174 Identity:224/1174 - (19%)
Similarity:355/1174 - (30%) Gaps:477/1174 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 PNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDM 559
            |...|:.|:.|:.......:|::....:...:|...:||::..     :...||||.||:||:|:
Human    17 PEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAV-----KLQLPDYYTIIKNPMDL 76

  Fly   560 NTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFP------- 617
            |||:..:....||...:.:.|:..|||||..||:.|.:|...|..||:...:||.:.|       
Human    77 NTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVG 141

  Fly   618 ----------------------------------------------------------------- 617
                                                                             
Human   142 VKERIKKGKAGGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQ 206

  Fly   618 ---GLTEGKK--------------------------------------------SQQKYSKVGRK 635
               .:|:|.|                                            |||:|:.|   
Human   207 TAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVV--- 268

  Fly   636 LKTAVITERLWQFYETVKE------------YQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPI 688
             ||..:||:|....|.:||            :..|.....|.|           .:|||:::.|:
Human   269 -KTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGL-----------HNYYDVVKNPM 321

  Fly   689 DMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDS 753
            |:..|.:|:....|......|||..||..|..|||.||.::...|.:||.:       ..|....
Human   322 DLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDV-------FETHFSK 379

  Fly   754 LPDVPLAVQELFLTLFTTIYNHQDEEGRCY-SDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKG 817
            :|..|:....|                 || ...:.|....:...|.......|.|....|:   
Human   380 IPIEPVESMPL-----------------CYIKTDITETTGRENTNEASSEGNSSDDSEDERV--- 424

  Fly   818 AYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNFSLERLM 882
              |||...||.:.|..::.:.||:..   |:.        :.|:.|..|.......:|.|.|.  
Human   425 --KRLAKLQEQLKAVHQQLQVLSQVP---FRK--------LNKKKEKSKKEKKKEKVNNSNEN-- 474

  Fly   883 ADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGE----------------SMTINQQVFSPGDYV- 930
             ..::|.|.:::::.:..:..|.|.:|...|.|                |:.||:   .|||.: 
Human   475 -PRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINK---LPGDKLG 535

  Fly   931 -YVQMPENKIPSI----------------------------CCIERLWTSPTNEKLMQASIFVRP 966
             .|.:.:::.||:                            .|:.:....|..:|:|.:.     
Human   536 RVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSK----- 595

  Fly   967 HETYHVTTRKFLEKEV------FKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCE 1025
             |..|...::.|||.:      ..|...||.| ||.|....|.|:....:....:....:.....
Human   596 -EELHSQKKQELEKRLLDVNNQLNSRKRQTKS-DKTQPSKAVENVSRLSESSSSSSSSSESESSS 658

  Fly  1026 SRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVE 1090
            |..:.......:.:.:|...|   ||  |.:.|         .||.::|.|.|            
Human   659 SDLSSSDSSDSESEMFPKFTE---VK--PNDSP---------SKENVKKMKNE------------ 697

  Fly  1091 KEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQNGKSYFK 1155
                   |.||.    |.|          |..:.|   |....|...:...|.|           
Human   698 -------CIPPE----GRT----------GVTQIG---YCVQDTTSANTTLVHQ----------- 727

  Fly  1156 GPWLLPPSETTPGLGKQ--FYRQEL-LLSTVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDV 1217
                ..||...|....|  |..||| .|.||:.:||:                            
Human   728 ----TTPSHVMPPNHHQLAFNYQELEHLQTVKNISPL---------------------------- 760

  Fly  1218 YICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDG 1282
                                              :|      :.||.|.:...|.:.::..|.|.
Human   761 ----------------------------------QI------LPPSGDSEQLSNGITVMHPSGDS 785

  Fly  1283 DTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDIS 1347
            ||..|.|:..|                                   .|:|.|...|.|:      
Human   786 DTTMLESECQA-----------------------------------PVQKDIKIKNADS------ 809

  Fly  1348 RMVGTEWKNL-----PSSVKQSWED------RASRQNEETA----ALRRELDDVQNSAS-PSSQV 1396
                  ||:|     ||.|.:|.::      :|:.:.|..|    .:|:.|:  ||:.. .:||.
Human   810 ------WKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLE--QNTKELKASQE 866

  Fly  1397 SQDVFGQVLTFECQWDKCDFQFEELSDCTEHCMSDSTGHIQR-HPQAGVETEYVCLW----RNCP 1456
            :|...|..||.|      .|..:..:.|        :|..|: |.|:....:...||    |:..
Human   867 NQRDLGNGLTVE------SFSNKIQNKC--------SGEEQKEHQQSSEAQDKSKLWLLKDRDLA 917

  Fly  1457 RVKK 1460
            |.|:
Human   918 RQKE 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360
Bromo_polybromo_II 191..294 CDD:99948
Bromo_polybromo_III 335..443 CDD:99951
Bromo_polybromo_IV 512..613 CDD:99949 31/100 (31%)
Bromo_polybromo_V 641..733 CDD:99946 28/103 (27%)
Bromo_polybromo_VI 758..867 CDD:99956 20/109 (18%)
BAH_polybromo 921..1040 CDD:240068 25/154 (16%)
BAH_polybromo 1120..1234 CDD:240068 19/116 (16%)
HMG-box 1320..1375 CDD:238037 13/65 (20%)
BRDTNP_001229735.2 Bromo_Brdt_I_like 27..133 CDD:99929 34/110 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..232 3/25 (12%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22971749 213..224 2/10 (20%)
Bromo_Brdt_II_like 276..377 CDD:99930 30/118 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..424 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..515 14/80 (18%)
BET 513..575 CDD:293640 9/64 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..702 23/121 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..928 10/44 (23%)
BRD4_CDT 909..951 CDD:293710 4/13 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.