DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and Brd3

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_001107046.1	Gene:	Brd3 / 67382	MGIID:	1914632	Length:	743	Species:	Mus musculus

Alignment Length:	945	Identity:	172/945 - (18%)
Similarity:	320/945 - (33%)	Gaps:	330/945 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQ 292
            |||:.:|::|:|:..|..:::.|.|.|.:|..:|...|..|..::|:|...|...|::|::||.|
Mouse    70 PDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQ 134

  Fly   293 R-----RIELEM------GKG-KLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDH 345
            :     :.|:|:      ||| |.|...::..|..:||:     ||....|.          |.:
Mouse   135 KVAQMPQEEVELLPPAPKGKGRKPAAGAQNAGSQQVAAV-----SSVSPATP----------FQN 184

  Fly   346 LYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTAD 410
            :  .|..|:.|.:...|                                         :..:||:
Mouse   185 I--PPTVSQTPVIAATP-----------------------------------------VPTITAN 206

  Fly   411 LYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEK 475
            :      .....|........|..::.::                             ..|.|..
Mouse   207 V------TSVPVPPPAAPPPPATPIVPVV-----------------------------PPTPPVV 236

  Fly   476 RKPG-RPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFME 539
            :|.| :.:.::.:.:.::.|.:.|.||.    .::...:.|:::.::       ...|||
Mouse   237 KKKGVKRKADTTTPTTSAITASRSESPP----PLSEPKQAKVVARRE-------SGGRPI----- 285

  Fly   540 KPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANI 604
            |||:|             |:                                        ||..:
Mouse   286 KPPKK-------------DL----------------------------------------EDGEV 297

  Fly   605 LERALNEKLKEFPGLTEGKKSQQKYSKVGRKLK--TAVITERL--------WQFYETVKEYQEPK 659
            .:.|             |||     .|:...|:  .:::.|.|        |.||:.|.
Mouse   298 PQHA-------------GKK-----GKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVD------ 338

  Fly   660 GKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNE 724
                        ....|..||:|||:.|:|:..:.:|:....|......|||..||..|..|||.
Mouse   339 ------------AEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNP 391

  Fly   725 PDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAE 789
            ||.::...|..||.:.     ::|..:  :||.|:....|.... ..|.:...|..|...:|.::
Mouse   392 PDHEVVAMARKLQDVF-----EMRFAK--MPDEPMEAPALPAPT-APIVSKGAESSRSSEESSSD 448

  Fly   790 LPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLS----RTDSDIFQDS 850
            ....|                               .|:     |||.:|:    :|....|||.
Mouse   449 SGSSD-------------------------------SEE-----ERATRLAELQEQTGCGAFQDQ 477

  Fly   851 IELQTYFIRKRDELCKDTLSSSALNFSLERL-MADVELCRQQKMQQEEQDQEQDKEKD---EFNA 911
            :            |...::...|::..|..| .|.|...:::|.::|::.:::||:||   |.:.
Mouse   478 L------------LNVSSVQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKDKDKEKEKHK 530

  Fly   912 AKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKL----MQASIFVRPHETYHV 972
            ||.|.....:...:.......:.|..|..|        |:..:.:|    .|||......|....
Mouse   531 AKSEEEKKAKAAPAAKQAQQKKAPTKKANS--------TTTASRQLKKGGKQASASYDSEEEEEG 587

  Fly   973 TTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIK--------------DYIKMRPENLPEKDVYV 1023
            ....:.||......::: :..:|:..:.:::..:              |:..::|..|.|.:.||
Mouse   588 LPMSYDEKRQLSLDINR-LPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYV 651

  Fly  1024 --CESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQE 1086
              |     :|.:..|.|.:....:...|.:.:.:|:..||::       ||:...|:|...|
Mouse   652 KSC-----LQKKQRKPLSTSGKKQAAKSKEELAQEKKKELEK-------RLQDVSGQLNSKK--- 701

  Fly  1087 TLVEKEKPNVSCDPPPNAEVGSTYYQQYNTICSGA 1121
             ..:|||...:....|:....|:..:..::..||:
Mouse   702 -PTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGS 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	22/70 (31%)
		Bromo_polybromo_III	335..443	CDD:99951	9/107 (8%)
		Bromo_polybromo_IV	512..613	CDD:99949	12/100 (12%)
		Bromo_polybromo_V	641..733	CDD:99946	27/99 (27%)
		Bromo_polybromo_VI	758..867	CDD:99956	17/112 (15%)
		BAH_polybromo	921..1040	CDD:240068	22/138 (16%)
		BAH_polybromo	1120..1234	CDD:240068	1/2 (50%)
		HMG-box	1320..1375	CDD:238037
Brd3	NP_001107046.1	Bromo_Brdt_I_like	33..139	CDD:99929	22/68 (32%)
		Bromo_Brdt_II_like	310..411	CDD:99930	31/123 (25%)
		BET	589..653	CDD:374956	9/64 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900