Protein Alignment polybromo and Pbrm1

DIOPT Version :10

• Sequence 1: NP_651288.1
• Gene: polybromo / 42954
• FlyBaseID: FBgn0039227
• Length: 1654
• Species: Drosophila melanogaster
• Sequence 2: NP_001074720.1
• Gene: Pbrm1 / 66923
• MGIID: 1923998
• Length: 1704
• Species: Mus musculus
• Alignment Length: 1851
• Identity: 629/1851 - (33%)
• Similarity: 956/1851 - (51%)
• Gaps: 348/1851 - (18%)

  Fly     1 MLSRKRRASSISSRQDEDPLQLDD---STPEQSPVQQTTTQSARKKRRL------DPTELCQQLY 56
            |.|::|||:|.||....|   .||   |.|...|        :||:|||      ||..:|.:||
Mouse     1 MGSKRRRATSPSSSVSGD---FDDGHHSVPTPGP--------SRKRRRLSNLPTVDPIAVCHELY 54

  Fly    57 DSIRNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELL 121
            ::||:.|.|.|.:||:.|||.||||.:|.||:||..||||:|:|||||.:.|||::.|.||.:||
Mouse    55 NTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDVNLLTADFQLL 119

  Fly   122 IGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPG--- 183
            ..||||:|.|.|.|::.|..||......|...:: .|.|::|              ...|.|
Mouse   120 FNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFVQ-KGEADDE--------------DDDEDGQDN 169

  Fly   184 ----GDGATDDEYNQ-YEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLI 243
                .||::.....: .|:|..:::.||:|.| ||:..:||.||||..|||||.:|:.||||:.|
Mouse   170 QGTLADGSSPGYLKEILEQLLEAIVVATNPSG-RLISELFQKLPSKVQYPDYYAIIKEPIDLKTI 233

  Fly   244 ATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIEL---EMGKGKLA 305
            |.:||..:|.|:..|.:|:..:.|||..:||||||::|||.|:|:||..::.|:   ||.|..|
Mouse   234 AQRIQNGSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMTKSSL- 297

  Fly   306 KRVKSLSSAAIAAL-----------------------KEEVD-------------SSDDEETS-- 332
             |:::.|:.|.|.|                       |..|.             .|:.||.:
Mouse   298 -RIRTASNLAAARLTGPSHNKSSLGEERNPTSKYYRNKRAVQGGRLSAITMALQYGSESEEDAAL 361

  Fly   333 -----KKGEGPMWAL---------FDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELI 383
                 ::||....::         |..||:...:..:.  .|..:....:.||.::.:|:|::.|
Mouse   362 AAARYEEGESEAESITSFMDVSNPFHQLYDTVRSCRNH--QGQLIAEPFFHLPSKKKYPDYYQQI 424

  Fly   384 KRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESL 448
            |.|||:.||.||||..:|..:..|..||.||.:|||:....:...:|..||:.::|.||  ::.|
Mouse   425 KMPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAK--KKEL 487

  Fly   449 EEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIK 513
            ....|::|.|:                       :.|::.|:........|:..|..:.:.....
Mouse   488 ARRDDIEDGDS-----------------------MISSATSDTGSAKRKRNTHDSEMLGLRRLSS 529

  Fly   514 KKILSIQKYLVDYSL--------GNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDR 570
            ||.:..|:..:.:::        ..||..::||.||.:|.|||||.||..|:|:..||||||.|:
Mouse   530 KKNIRKQRMKILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDK 594

  Fly   571 YAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRK 635
            ||..|.::.|.:|||.|.|.||||||.:|.||:|||:.|.:|.||...|.:.........|:.||
Mouse   595 YAGEEGMMEDMKLMFRNARHYNEEGSQVYNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRK 659

  Fly   636 -----LKTAVIT---ERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDR 692
                 .|:..:|   ::|.:.||.||.|.:.:|:| ||.||.:|||:||.||||..|::|:||::
Mouse   660 SGVSPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRR-LSAIFLRLPSRSELPDYYLTIKKPMDMEK 723

  Fly   693 IAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDS-LPD 756
            |...:....|..:|.:..||::|..|||.||||:|.||||||||.::.|:.::.|..:.|| :|:
Mouse   724 IRSHMMANKYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPN 788

  Fly   757 VPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKR 821
            |.|.:|||...||.::.:|||:|||||||||||:|..|.  ..|....::.|::::.::...|:|
Mouse   789 VTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDP--NSPNKPPLTFDIIRKNVESNRYRR 851

  Fly   822 LDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCK--DTLSSSALNFSLERLMAD 884
            ||::||.:|..|||||:::||||:|::|::|||.:|||.||||||  :.|.|.||:::.:.|..|
Mouse   852 LDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLHND 916

  Fly   885 VELCRQQKMQQEEQDQEQDKEKDEFNAAKGE-----------------SMTINQQVFSPGDYVYV 932
            ||..:::|:.:|.::.:..:|:::..|.|.|                 ..:....::..||||||
Mouse   917 VEKEKKEKLPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYV 981

  Fly   933 QMPE-NKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKV 996
            :..| |..|.|.||||||.....||.:....|.||:||:|:.||||||||||||.....:.:.|:
Mouse   982 EPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKI 1046

  Fly   997 QGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSWP-PVREGSSVKFVPREQPLE 1060
            .|.|.||.:|:|.|:.|||..::||:||||||:.:.:.|||:|.|. |:   |||:||||:.||.
Mouse  1047 LGKCVVMFVKEYFKLCPENFRDEDVFVCESRYSAKTKSFKKIKLWTMPI---SSVRFVPRDVPLP 1108

  Fly  1061 LKRVMSVF----KERLEKHKGELEELKLQETL-VEKEKPNVSCDPPPNAEVGSTYYQQ--YNTIC 1118
            :.||.|||    |...||:....::.:.::.. :||||.:|..: ..|.|.|..|::|  ||.:.
Mouse  1109 VVRVASVFANADKGDDEKNTDNSDDNRAEDNFNLEKEKEDVPVE-MSNGEPGCHYFEQLRYNDMW 1172

  Fly  1119 SGAIKTGDFVYVATQ-TGKQSVAQVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYRQELLLST 1182
               :|.||.|::.:. ..:..|.:::::|.::|.:||.||..:.|.||.....|.||::|:.||.
Mouse  1173 ---LKVGDCVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSN 1234

  Fly  1183 VEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHSPS 1247
            :||..|:..|:|:||||.:.:|:|.|||||.|:|:.:|||.|:|..|.::|.  ..:::|..|..
Mouse  1235 LEETCPMSCILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKF--KGLKRFSLSAK 1297

  Fly  1248 VTEDEIFYFKTPIKPSKD---------------------FKNELNELGMLEDSMDGDTPS----- 1286
            |.:|||:||:.||.|.|:                     ..:::.|:|. |||...:.||
Mouse  1298 VVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEMGE-EDSEVIEAPSLPQLQ 1361

  Fly  1287 --LSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKK---CLTGYILYSSEVRKSICQSNPDATFGDI 1346
              |::::..|....|  .|||.::|..|.|.:.|   .::||||:|||:|..|...:||.:||::
Mouse  1362 TPLANELDLMPYTPP--QSTPKSAKGSAKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGEL 1424

  Fly  1347 SRMVGTEWKNLPSSVKQSWEDRASR----QNEETAALRRELDDVQNSASPSS------------- 1394
            ||:|||||:||.::.|..:|:||::    |..|.||.::     |.||||.:
Mouse  1425 SRLVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQ-----QPSASPRAGTPVGALMGVVPP 1484

  Fly  1395 QVSQDVFGQVLTFECQWDKCDFQFEELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLWRNCPRVK 1459
            .....:..|.||                                 |.||:...|       |...
Mouse  1485 PTPMGMLNQQLT---------------------------------PVAGMMGGY-------PPGL 1509

  Fly  1460 KSVQAFPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRAPS 1524
            ..:|...:.|..:..::.:|                  |.......|...||..|.:  .|....
Mouse  1510 PPLQGPVDGLVSMGSMQPLH------------------PGGPPPHHLPPGVPGLPGI--PPPGVM 1554

  Fly  1525 NLEAVQLQQQQHPQQNMHQLQQQQTIVLGPPPE----------------------PLFVTVPPRT 1567
            |.....:.....|..:.:   .||..|||||.:                      |:||..||:|
Mouse  1555 NQGVAPMVGTPAPGGSPY---GQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKT 1616

  Fly  1568 TRVIHSEAYIKYIESLQTGSHLNVVTCNNNW------RRALTHITPAQVVAKTALPEKWIGPNLR 1626
            .|::|||||:||||.|...|  |.:   :.|      ||...|::..|   ::.||..|    |:
Mouse  1617 QRLLHSEAYLKYIEGLSAES--NSI---SKWDQTLAARRRDVHLSKEQ---ESRLPSHW----LK 1669

  Fly  1627 DQG---NVVQALCHLRNFMVDDILQIRRSCN 1654
            .:|   .:..||..||:.|:.|.|.||::.|
Mouse  1670 SKGAHTTMADALWRLRDLMLRDTLNIRQAYN 1700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:445827	55/117 (47%)
		Bromo_polybromo_II	191..294	CDD:99948	48/103 (47%)
		Bromo_polybromo_III	335..443	CDD:99951	35/116 (30%)
		Bromo_polybromo_IV	512..613	CDD:99949	48/108 (44%)
		Bromo_polybromo_V	641..733	CDD:99946	43/94 (46%)
		Bromo_polybromo_VI	758..867	CDD:99956	54/110 (49%)
		BAH_polybromo	921..1040	CDD:240068	58/119 (49%)
		BAH_polybromo	1120..1234	CDD:240068	44/114 (39%)
		HMG-box_PB1	1319..1376	CDD:438800	27/60 (45%)
Pbrm1	NP_001074720.1	Bromo_polybromo_I	44..156	CDD:99954	54/112 (48%)
		Bromo_polybromo_II	182..284	CDD:99948	48/102 (47%)
		Bromo_polybromo_III	383..484	CDD:99951	34/104 (33%)
		Bromo_polybromo_IV	534..637	CDD:99949	46/102 (45%)
		Bromo_polybromo_V	673..777	CDD:99946	48/104 (46%)
		Bromo_polybromo_VI	790..897	CDD:99956	53/108 (49%)
		BAH_polybromo	972..1089	CDD:240068	58/116 (50%)
		BAH_polybromo	1170..1288	CDD:240068	45/122 (37%)
		HMG-box_PB1	1395..1454	CDD:438800	26/58 (45%)