DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and brd4

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_001104751.1 Gene:brd4 / 570531 ZFINID:ZDB-GENE-030131-267 Length:1444 Species:Danio rerio


Alignment Length:1570 Identity:265/1570 - (16%)
Similarity:492/1570 - (31%) Gaps:505/1570 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 PDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIF-- 290
            ||||.:|::|:|:..|..:::...|:|..|..:|...|..|..::|:||..|...|::|:::|  
Zfish    80 PDYYKIIKNPMDMGTIKKRLESAFYTSAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKVFLT 144

  Fly   291 -----TQRRIELE--MGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYN 348
                 .|:.:|:.  .|||:...|.....:..:..:.|.:.:|           |......:|  
Zfish   145 KISEMPQQ
EVEISTTAGKGRGRGRRDPDMNMKVGPVLEPLTAS-----------PQTRGLSNL-- 196

  Fly   349 APGTSEHPGVTGPPLGN---------SLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANI 404
            .||    |...|||.|.         .:..||.|  .|.....|  |:...|:......|. .:.
Zfish   197 TPG----PQTRGPPQGPPTLPPQPIVQIQALPPR--VPPSLPTI--PLHAPQLGPPFSLGP-TDC 252

  Fly   405 SDLTADLYLMLDNAKKAFPTSHRTHKDALKMLK----LMNAKLVEESLEEGSDLDDEDAEEMDTE 465
            :.....:..:....:.|.|..|.....|..:|:    :.|.:   :|.:..:|.....|.:...|
Zfish   253 NPPAPIITAVPPPTQTALPPVHIQQSAAPPILQTPISIPNKR---KSQKRKADTTTPTANDQLNE 314

  Fly   466 VFTVSTQPEKRKPGR--PRINSNSNSNASHTPN--------------NSNSPKSNRIAINAAIKK 514
                 :.|.:.|.|:  ||   ..|:..|..|.              .:.|||            
Zfish   315 -----SSPAESKSGKTLPR---RDNTRPSKLPKKEAPDSQHHWTAAPGTPSPK------------ 359

  Fly   515 KILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYP-------------DYYDIIQNPIDMNTIEHNI 566
                 |:..:.|..|..:  :||.:|.....:|             ||:|||::|:|::||:..:
Zfish   360 -----QQEQLRYCSGIVK--DMFAKKHAAYAWPFYKPVDVDTLGLHDYHDIIKHPMDLSTIKDKL 417

  Fly   567 RTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTE---------- 621
            .|.:|...::..:|.|||||||.:||.....:...|..|:.....:..:.|...|          
Zfish   418 ETRQYREAQEFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEMLAPAPAPV 482

  Fly   622 --------------------------GKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEPKG 660
                                      ..:|....|:..|..:.|.:.|:|...:|.:....:|:.
Zfish   483 LHPAPVKTQPVMATASSSDTSSDSSSESESSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQA 547

  Fly   661 KRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEP 725
            .:         |.|.|        :|..:..:...|.|.|....|:::       ||........
Zfish   548 SK---------PKKKE--------KEKKEKKKDKHKKKAGVMPALEEI-------LEPPPALKPQ 588

  Fly   726 DSQIYKDALVLQQLTLQLKQQLRTERDSLPD--VPLAVQ---------ELFLTLFTTI------- 772
            .....||.|..:...|..|:..::.|...|.  .|..:|         :|.||....:       
Zfish   589 GKPKNKDPLPKKSKKLSKKEGGKSNRSMAPPGAAPPTLQPVPGLDTEEDLGLTGGAAMAGMAAGE 653

  Fly   773 ------YNHQDEEGRCYSDSLAELPEYDEIG--------EGPKVRGISLDLVK---RRLDKGAYK 820
                  |    ||.|..|..:.:||. |::|        ..|.::..:.|.::   ..|.....:
Zfish   654 KCKPMSY----EEKRQLSLDINKLPG-DKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLR 713

  Fly   821 RLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNFSLERLMADV 885
            .|:.|   :.:||.:.:|.:..:.       .::.....|......|:.|||             
Zfish   714 ELERY---VSSCLRKKKKPAVPEK-------SMEAISAVKTKGTSSDSGSSS------------- 755

  Fly   886 ELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWT 950
                 :....|.:|.|...........:||....:.|..:||      ||..::|         .
Zfish   756 -----ESSSSESEDSETGMASKPKKRGRGEGKKAHHQTTAPG------MPLPQVP---------L 800

  Fly   951 SPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIK----- 1010
            .|....| |.||.::..:..|.:...::...|.....||.:. :....:.:.|::..:..     
Zfish   801 QPQTPAL-QPSIQLKQQQPQHPSPAAYMPPPVTALEPSQLLE-NPFDPLAHFMHLPHHANDSSSP 863

  Fly  1011 -----------------------------------------MRPEN----LPEKDVYVCESRYN- 1029
                                                     .||.|    ||.|.:....|:.. 
Zfish   864 APPHLNAHPPGGPVSPETHPFLNQHPILPSPALHNALPQQPSRPSNRAAPLPPKPLQQSTSQQQP 928

  Fly  1030 ------IQGRWFKKLKSWPPVREGSSVKFVPREQPLELK-------------------------- 1062
                  :..:..:..:..|...:...:...|...|.:::                          
Zfish   929 PPQQTLVPPQQLQPQQQQPAPPQQQHLPHHPLHAPQQMRPRPLSPPTLTPQGLLSSQPPQMLLED 993

  Fly  1063 -------RVMSVFKERLEKHKGELEELKLQETLVEKEKP--------NVSCD---PPPNAEVGST 1109
                   :.:.::.:.|:.|:.:.....|.::|..:.:|        :|...   |||...|.:.
Zfish   994 DEEPVPSKSLPMYLQHLQPHRLQATPTSLMQSLQSRPQPPGQPSLLQSVQVQSHLPPPQLPVQTQ 1058

  Fly  1110 YYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFY 1174
            ...|......          .:.|..:.....:||:      .:.:||  |..::|.||..|   
Zfish  1059 VQPQQPAPHQ----------PSPQLSQHQARHMQQL------GFPQGP--LQTAQTQPGQHK--- 1102

  Fly  1175 RQELLLSTVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNM 1239
              ..:.||..:           .:::..:..........::|.|....:.|.....:        
Zfish  1103 --VSMPSTKAQ-----------QIIQQQQATQHHSPRQHKADSYNSAHLRDNPSPLM-------- 1146

  Fly  1240 RKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPA--PSVN 1302
               .|||.:.:..:.: ::|.:..|:.:...:.||.:::.....:|.:..:   ..|||  |..:
Zfish  1147 ---MHSPQIPQYSLVH-QSPSQDKKEPQRGPSALGGIKEEKLPPSPVMRGE---PFSPAMRPESH 1204

  Fly  1303 STPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWED 1367
            ..|.:.......|.::.....:..|..|.:|..||.|..:..|..:.                  
Zfish  1205 KHPDSKPTMPGHSQQRADMKPLEMSRPVIRSSEQSGPPPSMQDKEKF------------------ 1251

  Fly  1368 RASRQNEETAALRRELDDV-------------QNSASPSSQVSQDVFGQVLTFECQWDKCDFQFE 1419
               :|..:|.:..:::.||             ::|.:|||.:...                    
Zfish  1252 ---KQEPKTPSAPKKVQDVKFKNMGSWASLAQKSSTTPSSGLKSS-------------------- 1293

  Fly  1420 ELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLWRNCPRVKKSVQAFPNVLRLIKHVREVHLSKCG 1484
                      |||....:|..:...|.|            |:::|      .::...:..|.|..
Zfish  1294 ----------SDSFEQFRRAAREKEERE------------KALKA------QVEQAEKDRLRKEQ 1330

  Fly  1485 KTISAADRSKNFVPRRQKHAQLATTVPI-PPSLAQSPRAPSNLEAVQLQQQQHPQQNMHQLQQQQ 1548
            :.:...|...:..|.|:         |: .|...|.|:          |.|..|||:..|.|.| 
Zfish  1331 EKLRGRDEEDSIEPPRR---------PLEEPRRRQEPQ----------QVQPPPQQHQTQAQAQ- 1375

  Fly  1549 TIVLGPPPEP 1558
              .|.|...|
Zfish  1376 --TLNPAQSP 1383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360
Bromo_polybromo_II 191..294 CDD:99948 22/72 (31%)
Bromo_polybromo_III 335..443 CDD:99951 23/120 (19%)
Bromo_polybromo_IV 512..613 CDD:99949 30/113 (27%)
Bromo_polybromo_V 641..733 CDD:99946 15/91 (16%)
Bromo_polybromo_VI 758..867 CDD:99956 23/141 (16%)
BAH_polybromo 921..1040 CDD:240068 23/175 (13%)
BAH_polybromo 1120..1234 CDD:240068 15/113 (13%)
HMG-box 1320..1375 CDD:238037 8/54 (15%)
brd4NP_001104751.1 bromodomain 1; BD1 40..152 21/71 (30%)
Bromo_Brdt_I_like 43..149 CDD:99929 21/68 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..217 16/79 (20%)
bromodomain 2; BD2 356..473 34/135 (25%)
Bromo_Brdt_II_like 363..464 CDD:99930 29/102 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..523 3/30 (10%)
NPS region. /evidence=ECO:0000250 498..517 1/18 (6%)
BID region. /evidence=ECO:0000250 538..610 16/95 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..645 23/128 (18%)
ET domain 654..729 16/82 (20%)
BET 657..721 CDD:293640 14/71 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1020..1422 81/504 (16%)
C-terminal (CTD) region. /evidence=ECO:0000250 1126..1444 60/364 (16%)
BRD4_CDT <1419..1444 CDD:293710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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