DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and crebbpa

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:XP_005161826.1 Gene:crebbpa / 566841 ZFINID:ZDB-GENE-050208-439 Length:2350 Species:Danio rerio


Alignment Length:1869 Identity:333/1869 - (17%)
Similarity:592/1869 - (31%) Gaps:655/1869 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SRKRRASSISSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRRLDP-----TELCQQLYD----- 57
            |.:....:.|..|.:.|.|....||.|.|::..   :|....:|:|     :|..:.|.|     
Zfish   458 SNQNPTQTQSPTQTQGPGQTTAQTPHQQPMRSI---NALGGGQLNPIGVPTSEQAKLLPDGTMPS 519

  Fly    58 SIRNIKKEDGSM------------LCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDD 110
            ::.|....|||.            |..|.:|  |...|....|:..:.:..| ||....|.....
Zfish   520 TLNNPVMPDGSTVGNLSNLPTAAPLSATGVR--KAWHEHVTQDLRNHLVHKL-VQAIFPTPDPAA 581

  Fly   111 LDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRR 175
            |.|  ..:|.|:..|:.  :.|.. ::.|.|..::.|...::|.:.....||:.|: |:.:|:..
Zfish   582 LKD--RRMENLVAYARK--VEGDM-YESANSRDEYYHFLAEKIYKIQKELEEKRRS-RLQKQIIN 640

  Fly   176 MTSSTEPGGDGATDDEYN------------------------QYEE------LFASVMTATDPVG 210
            .||.|..|...:..::.|                        |..:      ..::|..:..|:|
Zfish   641 QTSMTATGQQPSALNQPNVMGPRPQNGPVPMPNVPNQILNRMQVSQGMNPFSAMSNVPMSQAPMG 705

  Fly   211 DR----LMHRMFQL--LPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNA 269
            .|    :.|:...:  :|:..:.|           .|:..|:..:.|:..      :::..|.|.
Zfish   706 TRAASPINHQQINMNQVPTMNMSP-----------TRIAPTQGMLGAHGG------NMVTQTPNQ 753

  Fly   270 CLF-NEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKRVK------SLSSAAIAALKEEVDSSD 327
            ..| .:|....           |...:.:.||:......|.      :|...|:..|...:....
Zfish   754 TQFMTQPPFPA-----------TTNTMNVNMGQPNSQTPVSQQQPNANLPLNALGPLGPALGCPT 807

  Fly   328 DEETSKKGEGPMWALFDHLYNAPGT------SEHPGVTGPPLGNSLWKLPV-RRFHP-----EYF 380
            ..:...:...|..|......|.|..      :..|....||...:..:||: .:.||     |  
Zfish   808 PPQAPLRATPPPNATAASTTNLPAALQPSTPTPAPAQATPPHMQTQAELPIPGQQHPGTPTGE-- 870

  Fly   381 ELIKRPIS--MSQIH------------TKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKD 431
            ..:..|.|  .:::|            ||.::.||              |.|.|..| |..|.:|
Zfish   871 NRVPTPASAASTELHSQHAVPDVPPNDTKTEEQDY--------------DMAVKTEP-STETEED 920

  Fly   432 ALKMLKLMNAKLVEESLEEGSDLDDE--DAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHT 494
            .       .:.||::..:|||:...|  :.|:..|::.|.:.:.::         |.:|..||.:
Zfish   921 T-------GSLLVKKEEQEGSEAKQEPMETEDKKTDLKTETKEEDE---------SKTNGTASSS 969

  Fly   495 PNNSN----SPKSNRIAINAAIKKKILSIQKYLVD-YSLGNRRPIEMFMEKPPRKIYPDYYDIIQ 554
            |:.|.    .|:..|.|:...::      ..|..| .||..|:|::     |.....|||:||::
Zfish   970 PSQSRRKIFKPEELRQALMPTLE------SLYRQDPESLPFRQPVD-----PILLGIPDYFDIVK 1023

  Fly   555 NPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYED----ANILERALNEKLKE 615
            ||||::||:..:.|.:|......|.|..|||:|...||.:.|.:|:.    |.:.|:.::..::.
Zfish  1024 NPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKYCSKLAEVFEQEIDPVMQG 1088

  Fly   616 FPGLTEGKK---SQQKYSKVGRKLKTAVITERLWQFYET-----VKEYQEPKGKRQLSLIFTKLP 672
            . |...|:|   |.|.....|::|.| :..:..:..|:.     .|.:.|.:|.   |:.....|
Zfish  1089 L-GYCCGRKYEFSPQTLCCYGKQLCT-IPRDGTYYSYQNRYHFCEKCFNEIQGD---SVTLGDDP 1148

  Fly   673 -------SKSEY---------PD------------------YYDII------------------R 685
                   ||.::         |:                  :|::|                  :
Zfish  1149 AQPQTMISKDQFERKKNDTLDPEPFVECKDCGRKMHQICVLHYEVIWPSGFICDNCLKKSAKSRK 1213

  Fly   686 EPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDS-QIYKDALVLQQLTLQLKQQLRT 749
            |.....:..|..:.|.|  ::|....:|.      :.|.|:: :::...:.....|:::|..::.
Zfish  1214 ENKFTAKRLQSTRLGTY--IEDRVNKYLK------RQNHPEAGEVFVRVVASSDKTVEVKPGMKA 1270

  Fly   750 E----RDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGI----- 805
            :    .:.:...|...:.||      .:...|....|:..  ..:.||......|..|.:     
Zfish  1271 KFVDTGEMMEAFPYRTKALF------AFEEIDGVDVCFFG--MHVQEYGSDCPFPNTRRVYISYL 1327

  Fly   806 -SLDLVKRRLDKGAYKRLDVYQEDIFACLERARKL------------SRTDSDIFQ--------- 848
             |:...|.|:     .|..||.|.:...||..:||            |..|..||.         
Zfish  1328 DSIHFFKPRM-----LRTAVYHEILIGYLEYVKKLGYVTAHIWACPPSEGDDYIFHCHPADQKIP 1387

  Fly   849 DSIELQTYFIRKRDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKEKDEFNAAK 913
            ....||.::.:..|:.           |: ||::.|.                    ||.|..|.
Zfish  1388 KPKRLQEWYRKMLDKA-----------FA-ERILHDY--------------------KDIFKQAT 1420

  Fly   914 GESMT-INQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKF 977
            .:.:| .|:..:..||:                   |.:...|.:                  |.
Zfish  1421 EDRLTSANELPYFEGDF-------------------WPNVLEESI------------------KE 1448

  Fly   978 LEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQG--RWFKKLKS 1040
            ||:|                              ..|...|::...||:.....|  :..||..:
Zfish  1449 LEQE------------------------------EEERKKEENTAACETPEGTPGDSKNAKKKNN 1483

  Fly  1041 WPPVREGSSVKFVPREQPLELKRVMSVFKERL----EKHKGELEELKLQE-TLVEKEKPNVSCDP 1100
            ....:..||:....:::| .:..|.:...::|    ||||.....:.|.. .:|....|.:..||
Zfish  1484 KKTNKNKSSLSRANKKKP-GMPNVANDLSQKLYATMEKHKEVFFVIHLHSGPIVNSLLPILDSDP 1547

  Fly  1101 PPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQNGKSYFKGPWLLPPSET 1165
            ..|.:                :..|...::.....|.        ||.:  |..:..|      :
Zfish  1548 LLNCD----------------LMDGRDAFLTLARDKH--------WEFS--SLRRCKW------S 1580

  Fly  1166 TPGLGKQFYR--QELLLSTVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICESVYDELK 1228
            |..:..:.:.  |:..:.|..|....|.....|.|.|               |..:|.:.|:   
Zfish  1581 TMCMLVELHNQGQDRFVYTCNECKHHVETRWHCTVCE---------------DFDLCINCYN--- 1627

  Fly  1229 KALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAA 1293
                                              :|..::::.:.|:   .:|.|:.|.|.:  |
Zfish  1628 ----------------------------------AKGHEHQMVKWGL---GLDDDSSSQSGE--A 1653

  Fly  1294 MSSPAPSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLP 1358
            ..||..|           ...|.::|:.. ::::.:.|.:.|                    :||
Zfish  1654 SKSPQES-----------RRLSIQRCIQS-LVHACQCRNANC--------------------SLP 1686

  Fly  1359 SSVKQSWEDRASRQNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTF------ECQWDKCDFQ 1417
            |..|.      .|..:.|...:|:    .|...|       |..|::..      .||.:||...
Zfish  1687 SCQKM------KRVVQHTKGCKRK----TNGGCP-------VCKQLIALCCYHAKHCQENKCPVP 1734

  Fly  1418 FEELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLWR----------------------------- 1453
            |         |:  :..|..|..|.....:...:.|                             
Zfish  1735 F---------CL--NIKHKLRQQQLQHRLQQAQMMRRRMATMQGRAMPQSLPSPPASTAPSTPTS 1788

  Fly  1454 -NCPRVKKSVQAFPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLA 1517
             ..|...::.|..||.               ..|.:|...|..: |...::.|     |:|    
Zfish  1789 HQQPNTPQTPQPLPNQ---------------PTTPNAVVMSPTY-PNTPRNGQ-----PLP---- 1828

  Fly  1518 QSPRAPSNLEAVQLQQQQHPQQNMHQLQQQQTIVLGPPPE--PLFVTVPPRTTRVIHSEAYIKYI 1580
            |:.:.....:|..|.|||.|   :.|..|||     |||:  |.....||..             
Zfish  1829 QASQGKPGPQASPLHQQQSP---LPQPPQQQ-----PPPQQPPQQQQQPPPM------------- 1872

  Fly  1581 ESLQTGSHLNVVT-CNNNWRRA-----LTHITPAQVVAKTALPEKWIGP 1623
             :::...|:.:|. ...|:|..     :.|..|....|... |.:.:||
Zfish  1873 -AVKMARHIEMVAQAQQNYRMTMNGLPMNHQQPRMPGAMQP-PMQLVGP 1919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 29/133 (22%)
Bromo_polybromo_II 191..294 CDD:99948 17/139 (12%)
Bromo_polybromo_III 335..443 CDD:99951 26/133 (20%)
Bromo_polybromo_IV 512..613 CDD:99949 32/105 (30%)
Bromo_polybromo_V 641..733 CDD:99946 19/149 (13%)
Bromo_polybromo_VI 758..867 CDD:99956 27/135 (20%)
BAH_polybromo 921..1040 CDD:240068 15/120 (13%)
BAH_polybromo 1120..1234 CDD:240068 17/115 (15%)
HMG-box 1320..1375 CDD:238037 7/54 (13%)
crebbpaXP_005161826.1 zf-TAZ 325..392 CDD:280324
KIX 548..628 CDD:280354 18/87 (21%)
PHA03193 <751..919 CDD:177555 35/195 (18%)
Bromo_cbp_like 980..1087 CDD:99927 35/117 (30%)
RING_CBP-p300 1099..1171 CDD:276805 13/75 (17%)
PHD_CBP 1172..1206 CDD:277117 2/33 (6%)
HAT_KAT11 1235..1542 CDD:285432 68/425 (16%)
ZZ_CBP 1598..1638 CDD:239077 10/91 (11%)
ZnF_TAZ 1659..1737 CDD:214717 21/135 (16%)
Med15 1902..>2333 CDD:255446 5/19 (26%)
Creb_binding 1957..2043 CDD:286163
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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