DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and ep300b

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_009297682.1	Gene:	ep300b / 565612	ZFINID:	ZDB-GENE-080403-15	Length:	2646	Species:	Danio rerio

Alignment Length:	1766	Identity:	315/1766 - (17%)
Similarity:	538/1766 - (30%)	Gaps:	639/1766 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSRKRRASSISSRQDEDPLQLDDST--PEQSPVQQTTTQSA--RKKRRLDPTE-----LCQQLY 56
            ||.|...|.|:          ::||:  .........|..||  ||....|.|:     |..:|.
Zfish   502 MLHRNMTAQSL----------MNDSSGVGNMGSAATATPPSAGMRKSWHEDITQDLRNHLVHKLV 556

  Fly    57 DSIRNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELL 121
            .:|  ....|.:.|.|       ||.|           :|:...:|::.|.|:..:.......||
Zfish   557 QAI--FPTPDPAALKD-------RRME-----------NLVAYARKVEGDMYESANSRAEYYHLL 601

  Fly   122 IGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEP---RARRMSRQVRRMTSSTEPG 183
            .  .|.:.|....|.:           :|.|:.:.:| ...:|   :|...|:.|.||.:   |.
Zfish   602 A--EKIYKIQKELEEK-----------RRTRLQKQDG-PHSDPSLVQATGPSQMVNRMQN---PA 649

  Fly   184 GDGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQ 248
            |...:.:..||:.:     :....|:|.|                     ...|:.:.....::.
Zfish   650 GMPHSLNGMNQFGQ-----VGMQQPMGQR---------------------ATPPLPMGANLNQMS 688

  Fly   249 MNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSS 313
            |.....:|:.....||.......|...|:.:.:.|..|.:         ..|:|.:.:. :..:.
Zfish   689 MQGTPRMAQPNVPQLQNQYMQNQFTGTGAGLGQGAVGLNQ---------PAGQGAMPQN-QMPTP 743

  Fly   314 AAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTG--PPL-------GNSLWK 369
            .:::.......|......|....||.....:|    |..:..||:..  |||       ..||..
Zfish   744 PSLSVHSPVAQSQSSVPVSGAAAGPQGPPSNH----PPPAPQPGLHTHCPPLRQNSPSPARSLTP 804

  Fly   370 LPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALK 434
            .|.....|......:.|    |.||                            |.|..|......
Zfish   805 TPAPHQTPPQLPGNQTP----QPHT----------------------------PNSSTTMAPPAS 837

  Fly   435 MLKLM--------NAKLVEESLEEG--------------------------SDLDDEDAEEMDTE 465
            .|..|        :::|.::|...|                          |.|..:.:..:|.:
Zfish   838 QLPPMAQGVASEKSSQLQQQSHGGGATGGPQTGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQ 902

  Fly   466 VFT--------VSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKY 522
            ..|        .|:|....:|..|..:............|.|..:.......||::.:|.|
Zfish   903 ASTPASVSSADPSSQLTSSEPTAPLDSKTEVKQQDEEEENENETEDKASGKMAAMQTEIKS---- 963

  Fly   523 LVDYSLGNRRPIEMFMEKPP-RKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFS 586
                           .|||. :|..|...:....|::.:|.|     |:...|:          :
Zfish   964 ---------------EEKPEIKKEEPAGDECKTEPMETSTAE-----DKKPEVK----------T 998

  Fly   587 NCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQFYET 651
            ..::....|:|                 ..|..|:.||.:.|..::.:.|...:  |.|::....
Zfish   999 EPKEEEVAGAN-----------------STPANTQSKKKEFKPDELRQALMPTL--EALYRQDPE 1044

  Fly   652 VKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLML 716
            ...:::|...:.|.:......|.....||:||::.|||:..|.:||..|.|........|..||.
Zfish  1045 SLPFRQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMF 1109

  Fly   717 ENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGR 781
            .||..||...|::||
Zfish  1110 NNAWLYNRKTSRVYK-------------------------------------------------- 1124

  Fly   782 CYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLSRTDSDI 846
             |...|||:.|.:            :|.|.:.|.....::|: :......|..:
Zfish  1125 -YCSKLAEVFEQE------------IDPVMQELGYCCGRKLE-FSPQTLCCYGK----------- 1164

  Fly   847 FQDSIELQTYFIRKRDELCKDTLSSSALNFSLER------LMAD-VELCRQ--QKMQQEE----Q 898
                            :||  |:...|..||.:.      |:|| ...|.:  .::|.|.    .
Zfish  1165 ----------------QLC--TIPRDAAYFSYQNSSPKYGLLADRYHFCEKCFNEIQGENVSLGD 1211

  Fly   899 DQEQDK---EKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCI--ERLWTSP--TNEK 956
            |..|.:   .||:|...|.:::. .:.:...||.      ..|:..||.:  |.:|.|.  .:..
Zfish  1212 DPTQPQTSINKDQFQRKKNDTLD-PELLLECGDC------GRKMHQICVLHNETIWPSGFICDGC 1269

  Fly   957 LMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPE--- 1018
            |.:::           :|||  |.:.....|.||    |: |......:.||:|.  :|.||
Zfish  1270 LKKSN-----------STRK--ENKYAAKRLPQT----KL-GNFLETRVNDYLKR--QNHPESGE 1314

  Fly  1019 ---KDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLEL--KRVMSVFKERLEKHKGE 1078
               :.|::.:....              |:.|...:||...:..|.  .|..::|         .
Zfish  1315 VTIRVVHISDKVVE--------------VKPGMKSRFVDSGEMSESFPYRTKALF---------A 1356

  Fly  1079 LEELKLQETL---VEKEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVA 1140
            .||:...:..   :..::....| ||||..                     .||:
Zfish  1357 FEEIDGTDVCFFGMHVQEYGSDC-PPPNQR---------------------RVYI---------- 1389

  Fly  1141 QVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYRQELL--LSTVEEVSPVVGIVGRCAVLEYSE 1203
                       ||........|.....|:    |.:.|:  |..|:::..|:|.:..|...|..:
Zfish  1390 -----------SYLDSVHFFQPRHLRTGV----YHEILIGYLEYVKKMGFVMGHIWACPPSEGDD 1439

  Fly  1204 FI-SSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHS-----PSVTED------EIFYF 1256
            :| ...|   |:..:...:.:.:..||.|.|.||   .:..|.     ...|||      |:.||
Zfish  1440 YIFHCHP---SDQKIPKPKRLQEWYKKMLDKAVT---ERIVHDYKDIFKQATEDRLTSAKELPYF 1498

  Fly  1257 KTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLT 1321
            :....|:. .:..:.||...|:....:..:.||:         |:::|...||....|:.||
Zfish  1499 EGDFWPNV-LEESIKELEQEEEERKREENNTSSE---------SIDATNGDSKNAKKKNNKK--- 1550

  Fly  1322 GYILYSSEVRKSICQSN------PDATFGDISR------------------MVGTEWKNLP---- 1358
                 :|:.:.|:.::|      |:.: .|:|:                  :.|....:||
Zfish  1551 -----TSKNKSSLSRANKKKPGMPNVS-NDLSQKLYATMEKHKEVFFVIRFIAGPAANSLPPISD 1609

  Fly  1359 ---------SSVKQSWEDRASRQNEETAALRRE-------LDDVQNSASPSSQVSQDVFGQVLTF 1407
                     ...:.::...|..::.|.::|||.       |.::.|.       :||.|    .:
Zfish  1610 PDTLMACDLMDGRDAFLTLARDKHLEFSSLRRAKWSSMCMLVELHNQ-------TQDRF----VY 1663

  Fly  1408 ECQWDKCDFQFEELSDCT-----EHCMS--DSTGHIQR------------HPQAGVETE------ 1447
            .|  ::|....|....||     :.|::  :..||..:            :.||...|:
Zfish  1664 TC--NECKHHVETRFHCTVCEDYDLCITCYNVKGHEHKMEKLGLGLDDESNNQAAASTQNPGDSR 1726

  Fly  1448 ------------YVCLWRN-------CPRVKKSVQAFPNVLRLIKHVREVHLSKC-GKTISAADR 1492
                        :.|..||       |.::|:.||               |...| .||......
Zfish  1727 RLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQ---------------HTKGCKRKTNGGCPI 1776

  Fly  1493 SKNFVP---RRQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQQQQHPQQNMHQLQQQQTI---- 1550
            .|..:.   ...||.| .|..|:|..|             .::.:...||..|:|||.|.:
Zfish  1777 CKQLIALCCYHAKHCQ-ETKCPVPFCL-------------NIKHKLRQQQLQHRLQQAQMLRRRM 1827

  Fly  1551 -----VLGPPP 1556
                 |..|||
Zfish  1828 ATMQRVGQPPP 1838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	22/116 (19%)
		Bromo_polybromo_II	191..294	CDD:99948	14/102 (14%)
		Bromo_polybromo_III	335..443	CDD:99951	22/124 (18%)
		Bromo_polybromo_IV	512..613	CDD:99949	14/101 (14%)
		Bromo_polybromo_V	641..733	CDD:99946	27/91 (30%)
		Bromo_polybromo_VI	758..867	CDD:99956	12/108 (11%)
		BAH_polybromo	921..1040	CDD:240068	25/128 (20%)
		BAH_polybromo	1120..1234	CDD:240068	20/116 (17%)
		HMG-box	1320..1375	CDD:238037	10/91 (11%)
ep300b	XP_009297682.1	zf-TAZ	318..385	CDD:280324
		KIX	534..614	CDD:280354	21/101 (21%)
		Bromo_cbp_like	1024..1142	CDD:99927	35/182 (19%)
		RING_CBP-p300	1154..1236	CDD:276805	19/111 (17%)
		PHD_SF	1237..1271	CDD:304600	8/39 (21%)
		HAT_KAT11	1300..1607	CDD:285432	73/403 (18%)
		ZZ_CBP	1663..1703	CDD:239077	8/41 (20%)
		ZnF_TAZ	1724..1802	CDD:214717	18/93 (19%)
		Creb_binding	<2164..2231	CDD:286163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810