DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and baz2ba

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:XP_021332704.1 Gene:baz2ba / 561095 ZFINID:ZDB-GENE-070615-37 Length:2318 Species:Danio rerio


Alignment Length:1913 Identity:339/1913 - (17%)
Similarity:626/1913 - (32%) Gaps:607/1913 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SRKRRA---SSISSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRRL--------DPTELCQQLY 56
            |.||.|   ||.||......|.|..|:......:..||||.......        .|..:.|...
Zfish   525 SNKRSAPLTSSSSSTSSSSVLPLKLSSEVSGRTKPPTTQSVSSSLPFSHGLLGLSQPNGVIQSTQ 589

  Fly    57 D---SIRNIKKEDGSMLCDTFIR--------VPKRRQEP---------------SYYDVVVNPID 95
            |   ::....:.|..:...|..|        .|.|.:||               |...:|.:.:|
Zfish   590 DVPLALTTKTRSDVPVNLSTGGRKSPASASPTPNRSREPRKTKTPKALEAWKGLSQNHLVQSLVD 654

  Fly    96 LLK---VQQKLKT-----DSYDDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQR 152
            |.:   .:|::.:     ||.:|.||...|:|             ..|..|.       ......
Zfish   655 LFQHSGAEQEVPSSKDSDDSAEDEDDEDDDVE-------------DEEDDDE-------EDSDDS 699

  Fly   153 IMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDG-ATDDEYNQYEELFASVMTATDPVGDRLMHR 216
            :.|::..::.|......:::.|:..|:.|...|| .|..:.|:      |::.::      ..|.
Zfish   700 LSESDSNSDSEMNGSEGTKKKRKDASAAEMDTDGEKTPQKLNK------SLLNSS------TNHS 752

  Fly   217 MFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYK 281
            :...||..      ..|:: |..:..........||.|         ..:.:..:...|||    
Zfish   753 LSDCLPLN------LQVVK-PASVATPTIVSSSGAYHS---------SPSSSYSVGTSPGS---- 797

  Fly   282 DAKSLKRIFTQ--RRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFD 344
             ||. ||:..:  .||.|||| .:...|:|:::...                  :|:...::   
Zfish   798 -AKR-KRVMNEDDLRIPLEMG-WQRETRIKTVAGRL------------------QGDVAYYS--- 838

  Fly   345 HLYNAPGTSEHPGVTGPPLGNSLWKLP-VRRFHPEY--FELIKRPISMSQIHTKLKKGDYANISD 406
                             |.|..|.:.| |.::...|  .::.:...|.|   .|::.||:....:
Zfish   839 -----------------PCGKRLRQYPDVVKYLSRYGITDITRDNFSFS---AKIRVGDFYEARE 883

  Fly   407 LTADLYLMLDNAKKAFPTSHRTHKDAL--KMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTV 469
            ....|...|.|.::..|     |..|:  :..:..|:...:....|||.                
Zfish   884 GPQGLQWTLLNEEEVIP-----HILAMEGRRGRPPNSDRQQRGSSEGSG---------------- 927

  Fly   470 STQPEKRKPGRPRINSNSNSNASHTPNNS---NSPKSNRIAINAAIKKKILSIQKYLVDYSLGNR 531
                .:|:.|||   .|...|...:|:.:   ...::..||..||..|.:..::|..:..:....
Zfish   928 ----SRRRKGRP---PNLGENEFPSPSEAKLLRKLEAQEIARQAAQMKLMRKLEKQALARAAKEA 985

  Fly   532 RPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGS 596
            |..:..|....|:...:...|::....:..|: .||.::....:.::...       |:..||.:
Zfish   986 RKQQAIMAAEERRKQKEQLKILKQQEKIKRIQ-QIRMEKELRAQQILEAK-------RKKREEAA 1042

  Fly   597 NIYEDANILERALNEKLKEFPGLTEGKKSQQ----KYSKVGRKLKTAVITERLWQFYETVKEYQE 657
            |    |.:||.....|.||.       :.||    |:.::.|..     .:.:|          |
Zfish  1043 N----AKMLEAEKRIKEKEM-------RRQQAVILKHQEMERHR-----LDMVW----------E 1081

  Fly   658 PKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKY 722
            .:.:||..::...:.::.:..:...:.:|..|..|:.::.|.       :|....|.|:....|.
Zfish  1082 RERRRQHVMLMKAVEARKKAEERERLRQEKRDEKRLNKERKM-------ELRRLELEMIREMKKP 1139

  Fly   723 NE---------------------PDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFL 766
            ||                     |.| ::.|.|::.|......:.|..:...||.:.: :||..|
Zfish  1140 NEDMCLTDHKPLPGVPRIPGLVLPGS-VFSDCLMVVQFLRSFGKVLGLDSSELPTLGI-LQEGLL 1202

  Fly   767 TLFTTIYNHQDEEGRCYSDSLAE--LPEYDE----IGEGPKVRGISLDLVKRRLDKGAYKRLDVY 825
            .|..::...||...|..|.::::  ||:...    :|:.....|::.|.|...|.  .|......
Zfish  1203 NLGNSMGQVQDLLVRLLSSAVSDPGLPQGHRAKSILGDHLTNVGLNRDNVSEVLQ--LYMEAHCS 1265

  Fly   826 QEDI-----------FACLERARKLS-----------------------------RTDSDIFQDS 850
            |.|:           |.....|:|.|                             |.|..|.:..
Zfish  1266 QTDLADLTLSLRTKAFQAHTPAQKASVLAFLVNELSCSKSVVSEIDKSLEHMNVLRKDECIVEGK 1330

  Fly   851 I-ELQTYFIR---KRDELC----KDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKEKD 907
            : :::|.:.:   ||:.:.    ......||:....:|...|.:   ....:.|:.|:::|.|::
Zfish  1331 LKKMKTIYAKRTGKRESMTGGEEPHAAGGSAIGHKRKRKAGDSD---DDDDEDEDSDEDEDDEEE 1392

  Fly   908 EFNAAKGESM-TINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYH 971
            |....||..: |.::....|                                             
Zfish  1393 EEETKKGRRVETCDEDEGDP--------------------------------------------- 1412

  Fly   972 VTTRKFLEKEVFKSSLSQTI-------SMDKVQGMCYVMNIKDYIKMRPENLPE-KDVYV--CES 1026
            .|:.:.|||::.|.|..|.:       |...::.|.|.   :|..:.|...||: ..||:  .||
Zfish  1413 ATSVEELEKQIEKISKQQNLIRRKLFESSHALRSMSYG---QDRFRRRYWILPQCGGVYIEALES 1474

  Fly  1027 RYNIQ--GRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLV 1089
            ...::  .:..::|::.|.|:    ||..|:|:.|:        ..:.|:.:|.|:|    |...
Zfish  1475 GEGLEELEKERERLRNCPVVQ----VKEEPKEEVLQ--------HHQHEEIQGTLKE----EVKQ 1523

  Fly  1090 EKEKPNVSCDPPPNAEVGSTYYQQYNTI-------------------------------CSGAIK 1123
            |:||| :..|..||.|..|:..:....:                               ||..|.
Zfish  1524 EEEKP-MDLDQEPNKEARSSPLKDKTDVVATPPQLPELRLSQSPQCQEPPHTPRHAHNGCSATIA 1587

  Fly  1124 TGDFVYVATQTGKQSVAQVQQIWEQNGKSYFKGPWLL--PPSETTPGLGK-QFYRQELLLSTVEE 1185
            . |....::.....:.:::.:....|.:.....|..|  |.....|.|.: |....:.|...:.|
Zfish  1588 M-DMTSGSSPAHSPTTSKLTEASSPNAEHAIPPPLQLGIPAHLLQPQLAQTQLLASDQLYKVLSE 1651

  Fly  1186 VSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTE 1250
            .|              ..:.|..|....:....|..|.:.:  .:.:...|....|....||.:.
Zfish  1652 RS--------------GHWFSLLPRSPCDDTSLIQPSAHPQ--SSPKSNATNTRPKSPPPPSTSS 1700

  Fly  1251 DE-----IFYFKTPIKP---------SKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPA--- 1298
            ..     :....:|:.|         |...|.....:|:...|..|..  :|.::...|||.   
Zfish  1701 PHHHLLPLSASASPLNPTAAAGISNLSVQVKPGAALVGLPLYSWSGGV--ISPNLPLCSSPLHMY 1763

  Fly  1299 PSV--NSTPLTS-KVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISR------------ 1348
            |||  :::||.: .|..:||.....|...|.|:          |.....|:.|            
Zfish  1764 PSVEGSASPLLAPSVSTSKSGSPVPTAEKLASA----------PSPVALDLPRNHDLPEPMAIPE 1818

  Fly  1349 --MVG----TEWKNLPSSVKQSWEDRASRQNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTF 1407
              ::|    |:.:.|.:.| .|...|..|:.    ||:::|           |.|.::..|.   
Zfish  1819 DMLLGWWKVTDMEELKALV-NSLHSRGIRER----ALQKQL-----------QKSMELIVQT--- 1864

  Fly  1408 ECQWDKCDFQFEELSDCTEHCMSDSTGHIQRHPQAGVET-EYVCLWRNCPRVKKSVQAFPNVLRL 1471
             |..:: :....|:|:..|             .|..||| :..|:         ..||....:.|
Zfish  1865 -CNKNR-EVAVMEVSELDE-------------GQVSVETLQEWCV---------EEQAMETDIAL 1905

  Fly  1472 IKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPR----------APSNL 1526
            ::.|.|:.    .|..||:.:.|.:            |.|.|    ||.|          .|.:.
Zfish  1906 LQQVEELE----RKVTSASLQVKGW------------TYPEP----QSEREDLVYFEHKPLPKHR 1950

  Fly  1527 EAVQLQQQQHPQQNMHQLQQQQTIVLGPPPEPLFVTVPPRTTRVIHSEAYI--KYIES-LQT--- 1585
            ...:.|:::..::.:          :..|..||.:.|    .|:...|.:|  :|:.| |.|   
Zfish  1951 PGAESQEERSSEKGL----------IRRPSNPLDIAV----MRLAELERHIERRYLRSPLGTTIQ 2001

  Fly  1586 -----------------------GSHLNVVTCNNNWRRALTHITPAQVVAKTALPEKWIGPNLRD 1627
                                   |....:......||:||:.:..:   ::.|:..:.:..::..
Zfish  2002 IKLDNVGTVTVPAPAPSTSAGGEGGEEEIAPGMKLWRKALSEVRSS---SQLAMCLQQLQKSIAW 2063

  Fly  1628 QGNVVQALCHL-RNFMVDDILQIRRSCN 1654
            :.::::..|.: |....:|:|.:...|:
Zfish  2064 EKSIMKVYCQICRKGDNEDLLLLCDGCD 2091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 25/153 (16%)
Bromo_polybromo_II 191..294 CDD:99948 17/104 (16%)
Bromo_polybromo_III 335..443 CDD:99951 19/112 (17%)
Bromo_polybromo_IV 512..613 CDD:99949 16/100 (16%)
Bromo_polybromo_V 641..733 CDD:99946 16/112 (14%)
Bromo_polybromo_VI 758..867 CDD:99956 28/162 (17%)
BAH_polybromo 921..1040 CDD:240068 20/130 (15%)
BAH_polybromo 1120..1234 CDD:240068 16/116 (14%)
HMG-box 1320..1375 CDD:238037 13/72 (18%)
baz2baXP_021332704.1 HAT_MBD 809..880 CDD:238691 20/112 (18%)
TPH 952..>1143 CDD:316391 41/231 (18%)
DDT 1167..1227 CDD:214726 14/60 (23%)
WSD 1450..>1470 CDD:317927 6/22 (27%)
WSD <1824..1856 CDD:317927 9/47 (19%)
PHD_BAZ2B 2070..2118 CDD:277100 5/22 (23%)
BAH 2093..>2145 CDD:322012
ADK <2119..2209 CDD:331878
Bromo_BAZ2A_B_like 2214..2310 CDD:99935
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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