DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and Cecr2

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_008761473.1	Gene:	Cecr2 / 500308	RGDID:	1564182	Length:	1465	Species:	Rattus norvegicus

Alignment Length:	607	Identity:	131/607 - (21%)
Similarity:	230/607 - (37%)	Gaps:	150/607 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DLLKVQQKLKTDSYDDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEAN-G 158
            ::.:::..|..|..|.:.||:|.|           :.|..:.:|...  |..||..:.|:... .
  Rat    40 EIEELEAALHRDDVDFISDLIACL-----------LQGCYQRRDITP--QTFHSYLEDIINYRWE 91

  Fly   159 LAEEEPRARR--------MSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMH 215
            |.|.:|...|        :..:|..:....:...|  .||.::..:.|.|..: ..:|:|:....
  Rat    92 LEEGKPNPLREASFQDLPLRTRVEILHRLCDYRLD--ADDVFDLLKGLDADSL-RVEPLGEDNSG 153

  Fly   216 RMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLA-EMERDLLQMTKNACLFNEPGSQI 279
            .::......::|.      |.|:..|       .|...||: |.||.     ||  :.|.||
  Rat   154 ALYWYFYGTRMYK------EDPVQGR-------SNGELSLSRESERQ-----KN--VSNVPG--- 195

  Fly   280 YKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSK----------- 333
                |:.||            :|:..||.|         |:||:.||:.:|.:.
  Rat   196 ----KTGKR------------RGRPPKRKK---------LQEEIISSEKQEENSLTSDLQTRNGS 235

  Fly   334 --KGEGPMWALFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELI----KRPISMSQI 392
              .|:|..|.|..........:|............|:||....|.||...:|    |||   .:.
  Rat   236 RGPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKGKRP---QRT 297

  Fly   393 HTKLK---KGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDL 454
            ..:|:   ..|:.:|.....:...||...:|    ..|..::..:.|.|...|..:|.:     |
  Rat   298 KPELQHRFMSDHLSIKSTKLEETPMLTKIEK----QKRKEEEEERQLLLAVQKKEQEQM-----L 353

  Fly   455 DDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKK----- 514
            .:|...|::.:|..|..:.::||....|  :...:.....|     |:.:.:.:|:.:::
  Rat   354 KEERKRELEEKVKAVEDRAKRRKLREER--AWLLAQGKELP-----PELSHLDLNSPMREGKKTK 411

  Fly   515 -------------KILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNI 566
                         |:|.:.|...|     ..|   |:|.......|:||.||:.|:|::::|..:
  Rat   412 DIFELDDDFTAMYKVLDVVKAHKD-----SWP---FLEPVDESYAPNYYQIIKIPMDISSMEKKL 468

  Fly   567 RTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKL-KEFPG----------LT 620
            ....|...|:.|:|.:.||.|||:||.:.|...:.:..|||..:..: |.|||          :.
  Rat   469 NGGLYCTKEEFVNDMKTMFRNCRKYNGDSSEYTKMSENLERCFHRAMTKHFPGEDGDTDEEFWIR 533

  Fly   621 EGKKSQQKYSKVGRKLKTAVIT 642
            |.:|.:::.|:.||...:.|.|
  Rat   534 EDEKREKRRSRAGRSSGSHVWT 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	13/63 (21%)
		Bromo_polybromo_II	191..294	CDD:99948	22/103 (21%)
		Bromo_polybromo_III	335..443	CDD:99951	24/114 (21%)
		Bromo_polybromo_IV	512..613	CDD:99949	30/118 (25%)
		Bromo_polybromo_V	641..733	CDD:99946	1/2 (50%)
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
Cecr2	XP_008761473.1	WHIM3	244..284	CDD:292248	9/39 (23%)
Cecr2	XP_008761473.1	Bromo_gcn5_like	418..518	CDD:99941	30/107 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900