DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and pbrm1l

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_005168819.1	Gene:	pbrm1l / 445141	ZFINID:	ZDB-GENE-010501-3	Length:	1657	Species:	Danio rerio

Alignment Length:	1814	Identity:	607/1814 - (33%)
Similarity:	934/1814 - (51%)	Gaps:	318/1814 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSRKRRASSISSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRR------LDPTELCQQLYDSI 59
            |.|::|||:|.||.....  ..||::       .:|..|..|:||      :|...:|.:||:::
Zfish     1 MGSKRRRATSPSSSASGG--DFDDAS-------SSTPVSGWKRRRASNAPSVDQIAVCHELYNTV 56

  Fly    60 RNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELLIGN 124
            |:.|.:.|..:|:.|:|.||||.:|.||::|..|||::|:||||:.:.|.|::...||..|||.|
Zfish    57 RDYKDDQGRQICELFVRAPKRRNQPDYYEIVSQPIDMMKIQQKLRAEEYQDVEQFSADFHLLINN 121

  Fly   125 AKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDG--A 187
            .||:|...|:||:.|..|.....|.:..:::                           ||||  |
Zfish   122 TKAYYQADSAEHRAASKLLNVFLSAKNELLQ---------------------------GGDGEEA 159

  Fly   188 TDDEYNQ---------------------YEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYY 231
            .|||.::                     .|:|..::.:.||..| ||:..:||.||||..|||||
Zfish   160 EDDEESEDAENTNASMEEERPPSYLKAILEQLLEAIASCTDSSG-RLVSELFQKLPSKLHYPDYY 223

  Fly   232 DVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIE 296
            .||:.|||||.:|.|||...|.|::.|.:|:..:.|||..:||||||::|||.::|::|.||:||
Zfish   224 AVIKEPIDLRAVAQKIQGGHYKSISAMAKDIDLLVKNAKTYNEPGSQVFKDANTIKKVFAQRKIE 288

  Fly   297 LEMGK-GKLAKRVKSLSSA-----AIAALKEEVDSSDDEETSKKGE-----------------GP 338
            :|..: .|.:.|:::..||     :...:..:..|..||::...|.                 .|
Zfish   289 IEQAEPTKTSLRIRNRRSAQGDRLSAITMALQAGSESDEDSILTGTVRYDTGETEADCGLSAGDP 353

  Fly   339 MWALFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYAN 403
            :..|:..:..|      ..|.|..|.....:||.||.:|:|:..||.|||:.||..|:|.|||..
Zfish   354 ILLLYQAVRGA------RSVQGLLLSEPFLQLPSRREYPDYYHQIKNPISLQQIREKMKNGDYEA 412

  Fly   404 ISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFT 468
            :..:.|||.:|.:||::....:...:|.|.::..:|..|..|..       ||::.:
Zfish   413 VEQIEADLSVMFENARRYNMPNSTIYKRAQRLQLIMQQKKREFR-------DDDEGD-------- 462

  Fly   469 VSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSL--GNR 531
            |||             :||:..:|...::..|.|.||:.:..|:          |.|...  ..|
Zfish   463 VST-------------ANSDVGSSKKKSHKKSAKKNRMKMLYAV----------LTDAREPGSGR 504

  Fly   532 RPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGS 596
            |..::||.||.:|.|||||.|||:|:||.|||:||||:||...:.::.|.:|||.|.|.||||||
Zfish   505 RLCDLFMVKPLKKDYPDYYKIIQDPMDMRTIENNIRTERYNNEDALMEDMKLMFRNARHYNEEGS 569

  Fly   597 NIYEDANILERALNEKLKEF-PGLTEG---------KKSQQKYSKVGRKLKTAVITERLWQFYET 651
            .:|.|||:||:.:.:|.||. |...|.         ::|....|....:::|..:.::|.:.||.
Zfish   570 QVYNDANVLEKMVKDKQKELGPAPEEDDVGSPKLKLRRSGVAVSPKKARIQTTPLQQKLSELYEA 634

  Fly   652 VKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLML 716
            |:.:.:.:|:| ||.:|.:|||:||.||||..|:.||||:||...:.||.|..:|.||.||:||.
Zfish   635 VRNFTDNRGRR-LSTVFLRLPSRSELPDYYAAIKRPIDMERIRSYMVQGRYQDVDSLAEDFILMF 698

  Fly   717 ENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERD----SLPDVPLA--VQELFLTLFTTIYNH 775
            .|||.||||:|.||:|||:|.:..|:.::::..|.:    .|..:.:|  |:||...||.::..|
Zfish   699 NNACTYNEPESLIYRDALLLHRAFLEARRRIEEEENGDEGGLGGLSVASLVRELIRNLFVSMMGH 763

  Fly   776 QDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLS 840
            ||:|||||||||||:|..|.  ..|....::|::::..:|.|.|:||||:||.:|..||:||:|:
Zfish   764 QDDEGRCYSDSLAEVPAIDP--ANPDDPPLTLEIIRNNVDSGRYRRLDVFQEHVFEVLEKARRLN 826

  Fly   841 RTDSDIFQDSIELQTYFIRKRDELCK--DTLSSSALNFSLERLMADVELCRQQKMQQE-EQDQ-- 900
            ||||:||:||:|||.:|::.||||||  :.|.:.||:::.:.|.:|::..:::|:.|| |:||
Zfish   827 RTDSEIFEDSVELQHFFVKIRDELCKNGEILLTPALSYTSKHLHSDIDQEKREKLPQEIEEDQLK 891

  Fly   901 -EQDK------EKDEFNAAKG-----------ESMTINQQVFSPGDYVYVQMPE-NKIPSICCIE 946
             |:||      :|.|..|..|           :..:.....:|.|||||||..| |..|.:.|||
Zfish   892 REEDKKALPEGDKAEGPAEGGQWPSGSQSSYSQDCSFENNTYSIGDYVYVQPAEANLQPHVVCIE 956

  Fly   947 RLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKM 1011
            :||...:.::.|....|.||.||:|:.||||||||:|||..:..:...|:.|.|:|:.:|||.|:
Zfish   957 KLWKDESGQQWMYGCWFYRPEETFHLATRKFLEKEIFKSDYNNRVPFSKILGKCFVLFVKDYFKL 1021

  Fly  1012 RPENLPEKDVYVCESRYNIQGRWFKKLKSW--PPVREGSSVKFVPREQPLELKRVMSVFKERLEK 1074
            :||....:|||||||||.::.:.|||:|.|  ||    :|||.:|||.||.:.||.|:|...
Zfish  1022 QPEGFKPEDVYVCESRYTVRTKAFKKIKIWSMPP----NSVKLLPREVPLPVVRVASMFVGA--- 1079

  Fly  1075 HKGELEELKLQET--LVEKEKPNVSCDPPPNAEVGSTYYQQ--YNTICSGAIKTGDFVYVATQ-T 1134
             |.:..:|...|:  .:|||:.:|..: .||.|:|..||:|  ||.:.   :|.||.||:.:. .
Zfish  1080 -KDKAADLPDGESGGFIEKEREDVPVE-VPNGELGCQYYEQLRYNDMW---LKLGDCVYIRSHGL 1139

  Fly  1135 GKQSVAQVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVVGIVGRCAVL 1199
            .:..|.:::::|.::|.::|.||..:.|.||.....|.||::|:.||::||..|:..::.:|.|.
Zfish  1140 VRPRVGRIEKMWLRDGAAFFFGPIFIHPEETEHEPTKMFYKREVFLSSLEENCPMTCVLRKCVVS 1204

  Fly  1200 EYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSK 1264
            .:.:|:|.||||..|.||.:.||.|.|.:|.::|...  :::|..|..|.:||||||:.||.|.|
Zfish  1205 SFKDFLSCRPTECPEEDVLLFESRYIESEKQMKKFKA--LKRFSLSAKVVDDEIFYFRKPIVPQK 1267

  Fly  1265 -----------DFKNELNELGMLEDSMD---------GDTPSL----SSDIAAMSSPAPSVNSTP 1305
                       :.:.:..::..|:|.||         ..|||:    :|..:.|..|.....|||
Zfish  1268 VPSPLLDKKIEELEAKFADMEDLDDDMDDLDDDDEEAAATPSMPPSQASTTSDMDMPYTPPQSTP 1332

  Fly  1306 LTSKVKAAKSAKK--CLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWEDR 1368
            ....:...:.||:  .::||||:|||||..|...:||.:||::||:|||||:||.::.|..:|:|
Zfish  1333 KIKGMSKKEGAKRKINMSGYILFSSEVRSLIKARHPDFSFGELSRLVGTEWRNLEATKKAEYEER 1397

  Fly  1369 ASR---QNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTFECQWDKCDFQFEELSDCTEHCMS 1430
            |::   |.|....|:::....|.......|
Zfish  1398 AAKLVEQQERERVLQQQHQQQQQQQQQQQQ----------------------------------- 1427

  Fly  1431 DSTGHIQRHPQAGVETEYVCLWRNCPRVKKSV-QAFPNVLRLIKHVREVHLSKCGKT----ISAA 1490
                  |..|:||.....:......|.....: ||.|.|..::.:....::...|..    :...
Zfish  1428 ------QASPRAGTPVGTMMGVVPPPSAMGMLNQAMPPVPGMMGNYGPPYMPMQGPEGMMGMGGT 1486

  Fly  1491 DRSKNFVPR-RQKHAQLATTVPIP---------PSLAQSPRAPSNLEAVQL------QQQQHPQQ 1539
            ......||: ..:|..|......|         |.:..|| .|.|...:|:      ||...|..
Zfish  1487 PPHLMGVPQLPSQHYLLPGMAGYPGMPHPGVMVPGMNGSP-GPGNPYGMQMAGYGPGQQAPPPYP 1550

  Fly  1540 NMHQLQQQQTIVLGPPPEPLFVTVPPRTTRVIHSEAYIKYIESLQTGSHLNVVTCNNNWRRAL-- 1602
            ...|...||      |..|:||..||:..|::|||||:||||.|...|     :..:.|.::|
Zfish  1551 GQGQPGHQQ------PAPPIFVAPPPKPQRLLHSEAYLKYIEGLSAES-----STVSKWDQSLKA 1604

  Fly  1603 ----THITPAQVVAKTALPEKWIGPNLRDQG---NVVQALCHLRNFMVDDILQIRRSCN 1654
                ..::..|   ::.||..|    |:.:|   .:..||..||:.|:.|.|.||::.|
Zfish  1605 QRKDCRLSREQ---ESHLPTHW----LKSKGAHTTMADALWRLRDLMMKDTLNIRQAYN 1656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	43/111 (39%)
		Bromo_polybromo_II	191..294	CDD:99948	49/123 (40%)
		Bromo_polybromo_III	335..443	CDD:99951	34/124 (27%)
		Bromo_polybromo_IV	512..613	CDD:99949	47/102 (46%)
		Bromo_polybromo_V	641..733	CDD:99946	45/91 (49%)
		Bromo_polybromo_VI	758..867	CDD:99956	57/112 (51%)
		BAH_polybromo	921..1040	CDD:240068	56/119 (47%)
		BAH_polybromo	1120..1234	CDD:240068	39/114 (34%)
		HMG-box	1320..1375	CDD:238037	28/57 (49%)
pbrm1l	XP_005168819.1	Bromo_polybromo_I	43..152	CDD:99954	43/108 (40%)
		Bromo_polybromo_II	184..286	CDD:99948	48/102 (47%)
		Bromo_polybromo_III	352..452	CDD:99951	33/105 (31%)
		Bromo_polybromo_IV	485..585	CDD:99949	50/109 (46%)
		Bromo_polybromo_V	624..723	CDD:99946	49/99 (49%)
		Bromo_polybromo_VI	746..853	CDD:99956	56/108 (52%)
		BAH_polybromo	933..1049	CDD:240068	56/115 (49%)
		BAH_polybromo	1123..1241	CDD:240068	40/120 (33%)
		HMG-box	1346..1408	CDD:238037	29/61 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580487
Domainoid	1	1.000	126	1.000	Domainoid score	I5359
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	930	1.000	Inparanoid score	I345
OMA	1	1.010	-	-		QHG52483
OrthoDB	1	1.010	-	-		D168080at2759
OrthoFinder	1	1.000	-	-		FOG0002672
OrthoInspector	1	1.000	-	-		otm26185
orthoMCL	1	0.900	-	-		OOG6_103614
Panther	1	1.100	-	-	O	PTHR16062
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2912
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770