DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and nej

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_001188575.1 Gene:nej / 43856 FlyBaseID:FBgn0261617 Length:3282 Species:Drosophila melanogaster


Alignment Length:1763 Identity:307/1763 - (17%)
Similarity:525/1763 - (29%) Gaps:691/1763 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   305 AKRVKSLS---SAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTGPPLGNS 366
            :.|:.|.|   |:.:|||:.....:|||..|..||..         |..|.|.:.|         
  Fly  1509 SSRMMSSSSSLSSQMAALEAAARDNDDETPSPSGENT---------NGSGGSGNAG--------- 1555

  Fly   367 LWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAF--------- 422
                                 .|:      .||   .:..:..|     |:.||.|         
  Fly  1556 ---------------------GMA------SKG---KLDSIKQD-----DDIKKEFMDDSCGGNN 1585

  Fly   423 -----------PTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDE---DAEEMDTEVFTVSTQP 473
                       ......:.|...|:|:      |...|:|  ||.|   ..|.||.:....||..
  Fly  1586 DSSQMDCSTGGGKGKNVNNDGTSMIKM------EIKTEDG--LDGEVKIKTEAMDVDEAGGSTAG 1642

  Fly   474 EKRKP---------GRPRINSNSNSNASH-----TPNNSNSP-KSNRIAINAAIKKK-------- 515
            |....         |:..||...:..|:.     .|.....| ....:|.||..|||        
  Fly  1643 EHHGEGGGGSGVGGGKDNINGAHDGGATGGAVDIKPKTETKPLVPEPLAPNAGDKKKKCQFNPEE 1707

  Fly   516 -----ILSIQK-YLVD-YSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAA 573
                 :.:::| |..: .|:..|.|::     |.....|||::|::.|:|:.||..||:..:|:.
  Fly  1708 LRTALLPTLEKLYRQEPESVPFRYPVD-----PQALGIPDYFEIVKKPMDLGTIRTNIQNGKYSD 1767

  Fly   574 VEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALN---EKLKEFPGLTEGKK---SQQKYSKV 632
            ..:.|.|..|||.|...||.:.|.:|.....|.....   :.:.:..|...|:|   :.|.....
  Fly  1768 PWEYVDDVWLMFDNAWLYNRKTSRVYRYCTKLSEVFEAEIDPVMQALGYCCGRKYTFNPQVLCCY 1832

  Fly   633 GRKLKTAVITERLWQFYETVKEY-------------------------QEP-KGKRQLSLIFTKL 671
            |::|.|.....:.:.:..::|||                         .:| :.:.|:.    |.
  Fly  1833 GKQLCTIPRDAKYYSYQNSLKEYGVASNRYTYCQKCFNDIQGDTVTLGDDPLQSQTQIK----KD 1893

  Fly   672 PSKSEYPDYYDIIREP-IDMDRIAQKLKQGAYDTLDDL-----AADFLLMLENA----CKYNE-- 724
            ..|....|:.::  || ::.....:|..|.....||.:     ..|..|..:|:    .|:|.  
  Fly  1894 QFKEMKNDHLEL--EPFVNCQECGRKQHQICVLWLDSIWPGGFVCDNCLKKKNSKRKENKFNAKR 1956

  Fly   725 -PDSQ--IYKDALVLQQL--------------------TLQLKQQLR----TERDSLPDVPLAVQ 762
             |.::  :|.:..|...|                    .:::|..:|    .:.:.:.:.|...:
  Fly  1957 LPTTKLGVYIETRVNNFLKKKEAGAGEVHIRVVSSSDKCVEVKPGMRRRFVEQGEMMNEFPYRAK 2021

  Fly   763 ELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGI---SLDLVKRRLDKGAYKRLDV 824
            .||      .:...|....|:..  ..:.||......|..|.:   .||.|  ...:....|..|
  Fly  2022 ALF------AFEEVDGIDVCFFG--MHVQEYGSECPAPNTRRVYIAYLDSV--HFFRPRQYRTAV 2076

  Fly   825 YQEDIFACLERARKLSRTDSDIF-------QDSI--------------ELQTYFIRKRDELCKDT 868
            |.|.:...::..::|..|.:.|:       .|.|              .||.::.:..|:     
  Fly  2077 YHEILLGYMDYVKQLGYTMAHIWACPPSEGDDYIFHCHPTDQKIPKPKRLQEWYKKMLDK----- 2136

  Fly   869 LSSSALNFSLERLMADVELCRQQKMQQ------------------------EEQDQEQDKEKDEF 909
                   ..:||::.|.:...:|.|:.                        :|.|||:::::.:.
  Fly  2137 -------GMIERIIQDYKDILKQAMEDKLGSAAELPYFEGDFWPNVLEESIKELDQEEEEKRKQA 2194

  Fly   910 NAAKGES----MTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHET- 969
            .||:..:    .:|.:...|.......|....|.......:|..:..:||           |:: 
  Fly  2195 EAAEAAAAANLFSIEENEVSGDGKKKGQKKAKKSNKSKAAQRKNSKKSNE-----------HQSG 2248

  Fly   970 ------YHVTTRKFLEKEVF----KSSLSQTISMDKVQG-----MCYVMNIKD------------ 1007
                  .:.|..|  .||||    ..|.....|:..:|.     .|.:|:.:|            
  Fly  2249 NDLSTKIYATMEK--HKEVFFVIRLHSAQSAASLAPIQDPDPLLTCDLMDGRDAFLTLARDKHFE 2311

  Fly  1008 YIKMRPENL-------------PEKDVYVC-------ESRYNIQ---------------GRWFKK 1037
            :..:|....             .:|.||.|       |:||:..               |...|.
  Fly  2312 FSSLRRAQFSTLSMLYELHNQGQDKFVYTCNHCKTAVETRYHCTVCDDFDLCIVCKEKVGHQHKM 2376

  Fly  1038 LKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEK------HKGELEE------------LKL 1084
            .|....:.:||::....:..|.|.:      |:.:::      |..:..:            |.:
  Fly  2377 EKLGFDIDDGSALADHKQANPQEAR------KQSIQRCIQSLAHACQCRDANCRLPSCQKMKLVV 2435

  Fly  1085 QETLVEKEKPNVSCD---------------------PPP---------NAEVGSTYYQQYN---- 1115
            |.|...|.|||..|.                     |.|         ..:.....:||..    
  Fly  2436 QHTKNCKRKPNGGCPICKQLIALCCYHAKNCEEQKCPVPFCPNIKHKLKQQQSQQKFQQQQLLRR 2500

  Fly  1116 -----------------------TICSGAIKTGDFVYVATQTGKQSVAQVQQIWE-QNGKSYFKG 1156
                                   |:.||.:..         .|...||..||:.. |.|      
  Fly  2501 RVALMSRTAAPAALQGPAAVSGPTVVSGGVPV---------VGMSGVAVSQQVIPGQAG------ 2550

  Fly  1157 PWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVV------GIVGRCAVLEYSEFISSRPTEISES 1215
              :||     ||.|      .:..|||...|||.      |:.|..:...:...|..:|......
  Fly  2551 --ILP-----PGAG------GMSPSTVAVPSPVSGGAGAGGMGGMTSPHPHQPGIGMKPGGGHSP 2602

  Fly  1216 DVYICESVYDELKKALRKLVT---GNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLE 1277
            ...:.:.|....::|.|:.|:   |..:....:|.|       ...|:..:...:|.:|:||.:.
  Fly  2603 SPNVLQVVKQVQEEAARQQVSHGGGFGKGVPMAPPV-------MNRPMGGAGPNQNVVNQLGGMG 2660

  Fly  1278 ----------------------DSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCL 1320
                                  :|..|:||.     |.:|.|..:||..                
  Fly  2661 VGVGGVGGVGVGGVGGVGVNQLNSGGGNTPG-----APISGPGMNVNHL---------------- 2704

  Fly  1321 TGYILYSSEVRKSICQ---------------SNPDATFGDISRMVGTEWKNLPSSVKQSWEDRAS 1370
                       .|:.|               .||.|.:.:                         
  Fly  2705 -----------MSMDQWGGGGAGGGGANPGGGNPQARYAN------------------------- 2733

  Fly  1371 RQNEETAALRRELDDVQNSASPSSQVSQ----------------DVFGQVLTFECQWDKCDFQFE 1419
                .|..:|:....:|.:..|..|..|                .|.||                
  Fly  2734 ----NTGGMRQPTHVMQTNLIPPQQQQQMMGGLGGPNQLGGGQMPVGGQ---------------- 2778

  Fly  1420 ELSDCTEH----------CMSDSTGHIQRHPQA----------GVETEYVCLWRNCPRVKKSVQA 1464
                   |          .|:.:.|.::..|.|          |:.|:.:.|.....:...:.::
  Fly  2779 -------HGGMGMGMGAPPMAGTVGGVRPSPGAGGGGGSATGGGLNTQQLALIMQKIKNNPTNES 2836

  Fly  1465 FPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRA---PSNL 1526
            ..::|.::|...::        ::|..:.:.   :.|.:|......|.|....|..:|   |.|.
  Fly  2837 NQHILAILKQNPQI--------MAAIIKQRQ---QSQNNAAAGGGAPGPGGALQQQQAGNGPQNP 2890

  Fly  1527 EAVQLQQQQH--------------------PQQ-NMHQLQQQQTIVL---------GPPPEPLFV 1561
            :..|.||||.                    ||| |.:|.||||.:.|         |.|...|  
  Fly  2891 QQQQQQQQQQQVMQQQQMQHMMNQQQGGGGPQQMNPNQQQQQQQVNLMQQQQQGGPGGPGSGL-- 2953

  Fly  1562 TVPPRTTRVIHSEAYIKYIESLQTGSHLNVVT-----CNNNWRRALTHITPAQVVAKTALPEKWI 1621
                 .||:.:....:..::||.......|.|     .|.||.: :.::..:|.  ....|::..
  Fly  2954 -----PTRMPNMPNALGMLQSLPPNMSPGVSTQGGMVPNQNWNK-MRYMQMSQY--PPPYPQRQR 3010

  Fly  1622 GPNLRDQG 1629
            ||::...|
  Fly  3011 GPHMGGAG 3018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360
Bromo_polybromo_II 191..294 CDD:99948
Bromo_polybromo_III 335..443 CDD:99951 17/127 (13%)
Bromo_polybromo_IV 512..613 CDD:99949 31/118 (26%)
Bromo_polybromo_V 641..733 CDD:99946 21/132 (16%)
Bromo_polybromo_VI 758..867 CDD:99956 24/132 (18%)
BAH_polybromo 921..1040 CDD:240068 29/181 (16%)
BAH_polybromo 1120..1234 CDD:240068 26/120 (22%)
HMG-box 1320..1375 CDD:238037 5/69 (7%)
nejNP_001188575.1 ZnF_TAZ 530..600 CDD:214717
KIX 946..1024 CDD:280354
Bromo_cbp_like 1705..1812 CDD:99927 28/111 (25%)
RING_CBP-p300 1824..1906 CDD:276805 12/87 (14%)
PHD_CBP_p300 1908..1939 CDD:277032 5/30 (17%)
HAT_KAT11 1970..2283 CDD:285432 55/347 (16%)
ZZ_CBP 2339..2379 CDD:239077 7/39 (18%)
ZnF_TAZ 2404..2476 CDD:214717 11/71 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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