Protein Alignment polybromo and Brd8

DIOPT Version :9

• Sequence 1: NP_651288.1
• Gene: polybromo / 42954
• FlyBaseID: FBgn0039227
• Length: 1654
• Species: Drosophila melanogaster
• Sequence 2: NP_651685.2
• Gene: Brd8 / 43460
• FlyBaseID: FBgn0039654
• Length: 872
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 120/599 - (20%)
• Similarity: 209/599 - (34%)
• Gaps: 151/599 - (25%)

  Fly     1 MLSRKRRASSISSRQDEDPLQLDDSTPEQSPVQQTTTQSA--RKKRRLDPTELCQQLYDSIRNIK 63
            ||..|..|:: .:.:....::.:.|..::..|.:.|:.:|  ......||.|  .||.:..:||.
  Fly   329 MLLEKNMAAA-KANESGSLVKPEGSGNQEQGVDEATSSAAGTADSDEADPNE--AQLLEVFKNID 390

  Fly    64 K-------EDGSMLCDTFIRVPKRRQEPSYYDVVVNP-------------IDLLKVQQKLKTDSY 108
            :       :..|::.|..::        :..|||.:|             :|.||.:|...:.:
  Fly   391 QIIDDIDIDMASVIDDEILK--------NVDDVVASPSNDKAEVIDFEDKLDALKREQSKSSPA- 446

  Fly   109 DDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANG--------LAEEEPR 165
               .|....:||:||:        |.:..|.:.| ..:.||..:....:|        .||.||.
  Fly   447 ---SDKPKSVELVIGS--------SDDSNDNIPL-AAVASQESKDRGQSGGESTRGTEDAESEPL 499

  Fly   166 ARRMSRQVRRM--------TSSTEPGG--------DGATD--------------DEYNQYEELFA 200
            ...::  |..:        |||.:..|        |||||              .|.:...:..|
  Fly   500 TSEVA--VEEIGETITIISTSSEDTAGSPPTKMEEDGATDSLPKKEDAAEDKSEQESSSQGQNKA 562

  Fly   201 SVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQM 265
            ...|....:.|....|..|....|       |....|:.::...|.........|.:.:.:...:
  Fly   563 GGSTDEPELIDHQATREAQSKSGK-------DTAGKPVTMQEKTTTQSAPVPVDLHDTDEESSSL 620

  Fly   266 TKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEM----------GKGKLAKRVKSLSSAAIAALK 320
            |.::...:.|.|...| ..:||......:.|||:          .:..|.:::.....:....:.
  Fly   621 TDSSKHDDHPRSAKAK-PPALKLALDDSKSELELSGTPQPPSAPARTPLLRKLPHRDRSESPMVD 684

  Fly   321 EEVDSSDDEETSKK-----GEGPMWALFDHLYNAPGTSEHPG------VTGPPLGNSLWKL---- 370
            ::..::.|..|::.     ...|   :.|.:.|:|.:|||..      .....|..|::.:
  Fly   685 DDATTASDHSTARSTRRRCSSTP---VIDSIPNSPASSEHTDDRRETRAASKKLFLSIYAMLLDS 746

  Fly   371 ----PVRR-FHPE----YFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSH 426
                |.:| ||.|    :.:|..||:....|...:..|...::|:|..|:.||..|...|:....
  Fly   747 KHAAPFKRPFHDEHAQRHADLCLRPMDFPTIKRNIDSGFIRSLSELHRDVLLMAHNVLVAYKPHT 811

  Fly   427 RTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNA 491
            ..||.|...::...|      ::|.|.|.|..|....|.|         ...|..|.:.:|.|.|
  Fly   812 AQHKTARLFVQDCQA------IKEFSQLPDVQAGITATPV---------SNTGSLRADKSSGSKA 861

  Fly   492 SHTPNNSNSPKSNR 505
                 .|.|.||.|
  Fly   862 -----RSGSRKSQR 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	27/131 (21%)
		Bromo_polybromo_II	191..294	CDD:99948	17/102 (17%)
		Bromo_polybromo_III	335..443	CDD:99951	30/126 (24%)
		Bromo_polybromo_IV	512..613	CDD:99949
		Bromo_polybromo_V	641..733	CDD:99946
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
Brd8	NP_651685.2	PaaSYMP	<105..188	CDD:291408
		PHA03249	402..>582	CDD:223023	40/202 (20%)
		Bromo_brd8_like	729..833	CDD:99939	25/109 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900