DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and dikar

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_001261480.1	Gene:	dikar / 38747	FlyBaseID:	FBgn0261934	Length:	3261	Species:	Drosophila melanogaster

Alignment Length:	1906	Identity:	336/1906 - (17%)
Similarity:	590/1906 - (30%)	Gaps:	544/1906 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SRKRRASSISSRQDED---------------------PLQLDDSTPEQSPVQQTTTQSARKKRRL 46
            ||.|..:.:.:||:|:                     |.|......:|...||.:.|..|::.:.
  Fly   275 SRIRNIAELKARQEEERQRRERENLYQDRQNAHWLAPPQQQQQQQQQQQQQQQQSQQRTRRRSQS 339

  Fly    47 DPTELCQQLY-DSIRNIKKEDGS-MLC--DTFIRVPKRRQEPSYYDVVVN-------PIDLLKVQ 100
            ..|......| .|:|.....:.| .||  :||...|:..::....|..::       |     .|
  Fly   340 TSTASGISTYASSLRRTTTTNSSEFLCHRETFCLSPENDEDDDDDDEALDAEQQSDQP-----EQ 399

  Fly   101 QKLKTDSYDDLDDLMADLELLIGNA--KAFYIPGSSEHQDAVSL--------------------- 142
            |:.:.:...:.:......|||..:|  ..|..|.:.:.|....|
  Fly   400 QRQQEEQPPEEEQRQEPEELLAVSATDDDFRSPEAPKSQTPAELKSKSSHHHHHHHHKKKKSSKK 464

  Fly   143 --------------WQHIHSQRQRIMEANGLAEEE--------------------------PRAR 167
                          .:|.|..|:|...|:...|.|                          |:.|
  Fly   465 QKKRHHRDKGRERDREHHHHHRRRHKHASEADEGEDDNNNHNSNSNSNSNTNSISSNNSVQPKRR 529

  Fly   168 RMSRQVR--RMTSSTEPGGDGATDDEYNQYEEL------FASVMTATDPVGDRLMHRMFQLLPSK 224
            |..:|.:  :...:|||....:.:|:.|...:|      .|::..||. :.|       ..|||.
  Fly   530 RSGQQQQHHQQAETTEPSTSLSPEDKENFCRQLQLLDTNSAAIAVATS-IAD-------LSLPSP 586

  Fly   225 KIYPDYYDVIEHPIDLRLIATKIQMNAYSSLA----------EMERDLLQMTKNACLFNEPGSQI 279
            ..:....:..|. :|...:.........|::|          :....|..:|.|  :|...||..
  Fly   587 VAHESETEQDEQ-VDQPAVVEAQPPALTSAMAPAANVKLPGRQTNNSLSSLTGN--IFIPSGSAQ 648

  Fly   280 YKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFD 344
            .:..:|.:.  .......:.|....|..|:|....|:      ::||....|||..:..     |
  Fly   649 QQQQQSQEP--PSSSSSSQSGTTTTASTVRSKKQKAV------LNSSGSSSTSKMADKA-----D 700

  Fly   345 HLYNAPGTS--EHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGD----YAN 403
            ...:...|:  ......|....:|..|  ..|....|.:               |.||    .:|
  Fly   701 RNLSKTETTGKSKKSAAGSSASSSSSK--AERISGAYSD---------------KSGDDHVNSSN 748

  Fly   404 ISDLTADLYLMLDNAKKAFP--------TSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAE 460
            .|....:..|..:|..|..|        .||.|...|........::....:.....:.:.:::.
  Fly   749 RSTTNNNSSLNNNNNHKHAPHHSHNNNNNSHSTTTSATTTATTTTSQGYHYNSNLNHNQNHQNSH 813

  Fly   461 EMDT------EVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIA------------ 507
            ...|      ...|.:....|.|       :.|:.:.:|..||:|||.:|..:
  Fly   814 SHHTHHHHHHHHHTTNNHSNKHK-------TKSHHSLAHNNNNNNSPTTNPTSTSLLHPVTTNNN 871

  Fly   508 -----------INAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNT 561
                       ::....:::|.|..:.|...:.|.|....|::.....|.|.||.||:.|:|:..
  Fly   872 STYNSSNHANILSFTETEEVLQIGMHKVLVYVKNHRDAWPFVDPVEEDIAPRYYSIIRRPMDLLK 936

  Fly   562 IEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKE-FPGLTEGKKS 625
            :|..:.:..|....:..:|:||:.:|||.||...:...|..|.|:.|..:..|: |..|::.:..
  Fly   937 MEDKLDSGEYHKFSEFRNDFRLIVNNCRLYNGHNNEYTEMVNNLQDAFEKATKKYFDNLSDDEDD 1001

  Fly   626 QQKYSKVGRKLKTAVITERLWQFYETVKEYQE---------PKGKRQLSLIFTKLPSKSEYPDYY 681
            ....|......|..|..|:  .|.:..||..|         ...:..||.|..:.|.|::.
  Fly  1002 DPNLSYPAADSKMNVFREK--YFSKKAKEETEKDAPGRPAVSSAEEDLSEIEAEAPQKAQK---- 1060

  Fly   682 DIIREPIDMD-RIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQ 745
               |:..:.| |..:|.|..|....||                                     :
  Fly  1061 ---RKRKEKDKRRKKKTKSKADVETDD-------------------------------------E 1085

  Fly   746 QLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRG-ISLDL 809
            .:..||:..|..|....:...|..|.....:|:|.....|...: .|......|.|.:. .|...
  Fly  1086 DMEAEREPTPPPPPPTSKKSKTSKTGKEKEKDKEKEKDKDKEKD-KETSSFKRGRKTKSDKSASK 1149

  Fly   810 VKRRLDKGAYK---------------RLDVYQEDIFACLERARKL----SRT------DSDIFQD 849
            ..::..|||.|               ..:.|.:|....|.:.:.|    :||      .|...:.
  Fly  1150 SSKKTKKGAKKSSADSDPESDPSDSRESEDYSDDDHISLAKTKSLVKPTARTIAAQKKKSVPAES 1214

  Fly   850 SIELQTYFIRKRDELCKDTLSSSALNFSLERLMADVELCRQ-------------QKMQQEEQDQE 901
            .:::.|..  ||....|......|.:.||:...:||.:.:|             .:::::..|..
  Fly  1215 KVKMPTPV--KRQVKGKGKGGRKAKDDSLDSDQSDVNVKKQLPPTAAAALAESAAELEEDPDDPP 1277

  Fly   902 QDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRP 966
            .|:::|| ::::..||                                 ||
  Fly  1278 PDEDEDE-DSSRSRSM---------------------------------SP-------------- 1294

  Fly   967 HETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQ 1031
               :.|...|...|......||:.::..|      .:...:..|:...:..|.|    |.|.:.:
  Fly  1295 ---FKVDLHKKYSKSALNDDLSELLTTVK------KVPTAETTKLSARHQDEAD----EERSSRE 1346

  Fly  1032 GRW-FKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVEKEKPN 1095
            ... ||.|.:    ..|||     .|:|...|:.......:.||.|...::.:.::...:|:|..
  Fly  1347 SDGDFKSLSN----SRGSS-----EERPPVAKKGKKAESSKKEKEKKGRDKDRDRDKEKDKDKSR 1402

  Fly  1096 VSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQNGKSYFKGPWL- 1159
            .:.|.....|         :.:...|.:....|..........:.:...|..:..::.|.|...
  Fly  1403 SAKDKKSKDE---------SPVLVAAAEAAAVVQAELDMLLPFMDKYDVIKYRRSRAAFSGSSAS 1458

  Fly  1160 --LPPSETTPGLGKQFYRQELLLSTVEEVSP--VVGIVGRCAVLEYSEFISSRPTEISESDVYIC 1220
              |.|||.:.....:..|:....|...|.||  |....||    :..:...|:.::.:|..
  Fly  1459 NSLAPSEDSKSAITKSNRENRKASAKREKSPDAVENKRGR----KSKDQKRSKESDKAEKS---- 1515

  Fly  1221 ESVYDELKKALRKLVTGNMRKFQHSPSVTED--------EIFYFKTPIKPSKDFKNELNELGMLE 1277
                |:..||..:..:...:|.:..|.|.|.        .:...:|..:|........:..|.::
  Fly  1516 ----DKASKADTEKHSEKSKKKEEPPKVVEKAQREKSPAPVSALETIKEPPAPTPIATSASGKVK 1576

  Fly  1278 DSMDGDTPSLSSDIAAMSSPAPSVNSTPLTS--KVKAAKSAKKCLTGYILYSSEVRKSICQSNPD 1340
            :......|....|......|.|:..|:...|  |..:.|:|:|  .|....::...........:
  Fly  1577 EGPAKKEPKKRPDKQMPPPPKPADKSSEKGSGKKSSSKKAAQK--AGQPQTNNNTNLEALDVETE 1639

  Fly  1341 ATFGDISRMVGTEWKNLPSSVKQSWEDRASRQNEETAALRRELDDVQNSASPSSQVSQDVF---- 1401
            .|..||:|                |.:...|..|.::|          |.|||.....|.|
  Fly  1640 QTLKDINR----------------WLEHTPRFTEFSSA----------SNSPSRYNLLDDFDSGI 1678

  Fly  1402 GQVLTFECQWDKCDFQ-----FEELSDCTEHCMSDSTGHIQRHPQAGV---ETEYVCLWRNCPRV 1458
            |..|      |..||:     ....::.....::::...:...|:..|   |:|
  Fly  1679 GSKL------DAADFRRPVALAAPKAELVPTKLAEALNELVSEPKEAVSKSESE----------- 1726

  Fly  1459 KKSVQAFPNVLRLIKHVREVHLSKCG-----------------KTISAADRSKNFVPRRQKHAQL 1506
              ||...|:.:.          |.||                 ...|:::.|.|.:|.....|..
  Fly  1727 --SVAPTPSSVS----------SSCGTPPHSMHSGNSIGSTSATAASSSNCSNNSMPTPLPVAVT 1779

  Fly  1507 ATTVPIPPSL--AQSPRAPSNLEAVQLQQQQHPQQNMHQLQQQQTIVLGPPPEPLFVTVPPRTTR 1569
            .|..|.||.|  ...|:.||..:                      ::|.|||       ||...:
  Fly  1780 PTPTPAPPPLLPIPKPKEPSTTQ----------------------LILNPPP-------PPHIKQ 1815

  Fly  1570 VIHSEAYIKYIESLQT--GSHLNVVTCNNNWRRALTHITPAQVVAKTALPEKWIGPNLRDQGN-- 1630
            .:..||..|.::..|.  .:....|....|..|.:..:.|.:  ||..|.:..:.....::|.
  Fly  1816 QLAKEAKRKSLKEKQAAQAAQAQQVKAKANVMRTIDRLQPGK--AKGNLLQNVVAVKSTEEGGDS 1878

  Fly  1631 ------VVQALCHLRNFMVDD 1645
                  |...:..|:|.::.:
  Fly  1879 HAGVNPVTTKVKELKNALITE 1899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	27/159 (17%)
		Bromo_polybromo_II	191..294	CDD:99948	20/118 (17%)
		Bromo_polybromo_III	335..443	CDD:99951	20/121 (17%)
		Bromo_polybromo_IV	512..613	CDD:99949	28/100 (28%)
		Bromo_polybromo_V	641..733	CDD:99946	18/101 (18%)
		Bromo_polybromo_VI	758..867	CDD:99956	24/134 (18%)
		BAH_polybromo	921..1040	CDD:240068	16/119 (13%)
		BAH_polybromo	1120..1234	CDD:240068	22/118 (19%)
		HMG-box	1320..1375	CDD:238037	7/54 (13%)
dikar	NP_001261480.1	WHIM1	100..148	CDD:292246
dikar	NP_001261480.1	Bromo_gcn5_like	892..991	CDD:99941	29/98 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900