DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and tou

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_001097270.1 Gene:tou / 36241 FlyBaseID:FBgn0033636 Length:3131 Species:Drosophila melanogaster


Alignment Length:1767 Identity:305/1767 - (17%)
Similarity:579/1767 - (32%) Gaps:654/1767 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 DED-PLQLDDSTPEQSPVQQTTTQSARKKRRLDPTELCQQLYDSIRNIKKEDGSMLCDTFIRVPK 79
            ||| ..:|:|       ::..|.|:...::|::..:..|.:.|: :.::||              
  Fly  1044 DEDVAKRLED-------LKVFTRQTLNVEQRIEIAKQQQAMRDA-KKLQKE-------------- 1086

  Fly    80 RRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQ 144
                           :|.:.::|.:.:....|:....|.||              ::|.||    
  Fly  1087 ---------------ELARNKEKARQEKNSKLEQQRKDKEL--------------KNQQAV---- 1118

  Fly   145 HIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPV 209
              ..:::|..|.:.|.:||...::..::.||..:..      |.:.|..:.:|:    :.|.:..
  Fly  1119 --EERKKRQEELDRLKQEELLKKQQEKEKRRQEAIL------AKEQELQKQKEM----LLAAEME 1171

  Fly   210 GDRLMHRM--FQLLPSKKIYPDYYDVIEHPIDL-RLIATKIQMNAYSSLAEMERD--LLQMTKNA 269
            .:|....|  .::|..::.:.| .:..:|.:.| ||:..:.:|      ||.:||  :||:.:..
  Fly  1172 RERRRQHMSLIRMLELRRKFED-REKKKHQLVLDRLLLRERRM------AERKRDAEILQLIRRP 1229

  Fly   270 CLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKK 334
            ...:|...::.  ...|.||...|                 |...|:|.|               
  Fly  1230 NEDSEMPQELV--IPELDRIAGNR-----------------LPGQAMADL--------------- 1260

  Fly   335 GEGPMWALFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKG 399
                 ..:|:.|:|          .|..||..:..||                |:..:|..|...
  Fly  1261 -----LMVFEFLHN----------FGETLGFDMESLP----------------SLQNLHDALMSD 1294

  Fly   400 DYAN-----ISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDL---DD 456
            ..|:     :|.:|..|...:::.....|..|.|    |....|.||.:...::.|...:   ..
  Fly  1295 SNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTT----LLGQSLRNADITNSNVSEILRIYLYAT 1355

  Fly   457 EDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNN---------------SNSPKS--- 503
            ...|.......||..:.|:|.|...:::|::.:: ||:..|               |.|.|.   
  Fly  1356 ATGEVRQMHGITVDRERERRVPDHHQLDSDTTTH-SHSVKNQEYYKLLHENDTWKLSQSLKDRPF 1419

  Fly   504 ----------------NRIAINAAIKKKI---------LSIQKYLVDYSLGNRRPIEMFMEKPPR 543
                            |.:.:|.|:.::|         :..:||:.|..:...:.:.|      |
  Fly  1420 VALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHM------R 1478

  Fly   544 KIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERA 608
            |...:.|:..|             .:|.||::.:::..:|.....:...|..:...|:|......
  Fly  1479 KARIEAYERAQ-------------AEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGT 1530

  Fly   609 LNEKLK------EFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEP--------- 658
            ..|..|      |.|  .:|.::::..:|                  |..::.|:|         
  Fly  1531 DGEATKGGSPNGEKP--EDGDQNEEGAAK------------------EPQQQQQQPMEVDGVVDE 1575

  Fly   659 -----KGKRQLSLIFTKLPSKSEYP-DYYDIIREPI---------DMDRIAQKLKQGAYDTLDDL 708
                 ..|..:....:..|||.:.| ..|.|.....         ||:.:.|..|.||.::::| 
  Fly  1576 ASLVSPAKTIIQTDNSLTPSKQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSIND- 1639

  Fly   709 AADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIY 773
                               :.:.|..::.              |.|.|:...:..:         
  Fly  1640 -------------------EHHHDVSIID--------------DDLSDLDSEITNV--------- 1662

  Fly   774 NHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYK-RLDVYQEDIFACLERAR 837
             .:||:.|..:|.|.:  :.|:|     ||. ||: .|..|:|...: |...:.:|.|  ..|..
  Fly  1663 -EEDEDNRLSADELQK--KLDKI-----VRA-SLN-CKEALEKSTNQLRAACFGQDRF--WRRYW 1715

  Fly   838 KLSRTDSDIFQDSIELQTYFIRKRDELC-------------------------KDTLSSSA---- 873
            ||.:. ..||.:::|      ..::::|                         ||..:.|:    
  Fly  1716 KLPKA-GGIFIEALE------SAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPM 1773

  Fly   874 -LNFSLERL-----MADVEL--CRQQKMQQEEQDQEQDKEKDEFNAAKGESMTI---NQQVFSPG 927
             ::.|:.:|     .:||.:  ..||...|:|:|.:.|  ..|.|..:.|.:.:   :.....|.
  Fly  1774 EVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDD--VTEINKVEPEIVDLGDDDDDAAPPL 1836

  Fly   928 DYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTI- 991
            ..:....||.|:.|            ..:||      .|..|..::|:...|.|:...|:...: 
  Fly  1837 PKIEPPRPEIKVKS------------EMELM------GPPPTTMISTKTDFEAEIKIPSMPGILM 1883

  Fly   992 -------------------SMDKVQ-GMCYVMNIKDYIK--MRPENLPEKD--VYVCESRYNIQG 1032
                               :.||:: |:......:::.:  ::.|::.::|  :.|..|..:...
  Fly  1884 PPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTP 1948

  Fly  1033 RWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVEKEKPNVS 1097
            :||               ..|.||.||                   :.||..:|..|..::..:|
  Fly  1949 KWF---------------SIVRREVPL-------------------ISELPAEEGGVVGQELQIS 1979

  Fly  1098 CDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQ---QIWEQ-NGKSYFKGPW 1158
                         |...|  ||                    ||:|   ..|:. |...|:.   
  Fly  1980 -------------YANQN--CS--------------------AQLQLQGHPWDLINNMQYYS--- 2006

  Fly  1159 LLPPSE---TTPGLGKQF------YRQELLLSTVEEVSPVVGIVGRCAVLEYSEFISS--RPTEI 1212
             :|..|   .|..||.:.      ..::.:|:.|||.        :...:|....:.|  |..|.
  Fly  2007 -IPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEY--------KAHKVESKNGLGSPHRHHET 2062

  Fly  1213 SESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKP--------SKDFKNE 1269
            .:.:        ::.|..|.|.:...| :........:::.|..::.:.|        ..|.|.:
  Fly  2063 KDDE--------EQAKLKLDKEIDTEM-ETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPK 2118

  Fly  1270 LNELGMLEDSMDGDTPSLSSDIAAMS-----------SPAPSVNSTP----LTSKVKAAKSAKKC 1319
            : || .|::::   :.:...:||.||           .|.| ::.||    |..:||.|...::.
  Fly  2119 I-EL-RLDEAL---SQAYYHNIANMSLSSVQTYIPIDIPLP-LSMTPDEHRLLEQVKLAGFPERV 2177

  Fly  1320 LTGYI-----------------------LYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSV 1361
            ...|:                       |..|.:|:...|.|.....| :.:.:|..:| |.|.:
  Fly  2178 HGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRFLG-LEQPLGVNYK-LKSDI 2240

  Fly  1362 -----------KQSWEDRASRQNEETAALRRELDDVQNSASPSS------QVSQDVFGQVLTFEC 1409
                       |..|..:.:::.|  .||..:|:.:::..:.:|      |:...|..: ||.:.
  Fly  2241 DFPEEFLMPDKKGDWNPKVAKRVE--LALIEQLESLEDKVASASMQLKNWQLPNRVESE-LTLDS 2302

  Fly  1410 QWDKCDFQFEELSDCTEHCMSDSTGHIQRH---PQAGVETEYVCLWRNCPRVKKSVQAFPNVLRL 1471
            |.|..:..|..:.......:.|...:|:|.   |..|.:|                         
  Fly  2303 QEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQT------------------------- 2342

  Fly  1472 IKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQQQQH 1536
                .:.||:...:......:::|                       |..|.:.|  :|:||||.
  Fly  2343 ----GDAHLAVIAQNQHTTTQTQN-----------------------SASAAAYL--LQMQQQQQ 2378

  Fly  1537 PQQNMHQLQQQQ 1548
            .||...|.||||
  Fly  2379 QQQLAQQQQQQQ 2390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 15/111 (14%)
Bromo_polybromo_II 191..294 CDD:99948 22/107 (21%)
Bromo_polybromo_III 335..443 CDD:99951 22/112 (20%)
Bromo_polybromo_IV 512..613 CDD:99949 17/109 (16%)
Bromo_polybromo_V 641..733 CDD:99946 17/115 (15%)
Bromo_polybromo_VI 758..867 CDD:99956 24/134 (18%)
BAH_polybromo 921..1040 CDD:240068 22/143 (15%)
BAH_polybromo 1120..1234 CDD:240068 21/128 (16%)
HMG-box 1320..1375 CDD:238037 13/88 (15%)
touNP_001097270.1 HAT_MBD 953..1027 CDD:238691
ZapA 1021..1127 CDD:294720 22/139 (16%)
MAP7 1043..1198 CDD:283355 36/221 (16%)
RILP-like 1085..>1179 CDD:304877 23/152 (15%)
DDT 1255..1317 CDD:280886 18/107 (17%)
WHIM1 1406..1455 CDD:292246 7/48 (15%)
WHIM3 2190..2224 CDD:292248 5/33 (15%)
PHD_BAZ2A_like 2640..2685 CDD:277020
RanBP2-type Zn finger 2640..2659 CDD:275375
RanBP2-type Zn finger 2680..2698 CDD:275376
PHD 2695..2744 CDD:279022
Bromo_BAZ2A_B_like 3027..3123 CDD:99935
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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