DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and brdt

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_002662470.2	Gene:	brdt / 333996	ZFINID:	ZDB-GENE-030131-5928	Length:	1093	Species:	Danio rerio

Alignment Length:	1278	Identity:	240/1278 - (18%)
Similarity:	419/1278 - (32%)	Gaps:	351/1278 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQ 292
            ||||.:|::|:||..|..:::.|.|....|...|...|..|..::|.||..|...|:.|:::|.:
Zfish    66 PDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLE 130

  Fly   293 RRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPG 357
            :                      :|.:.||    :.|.::...:||:...   ..:..|..:.|
Zfish   131 K----------------------VAEMPEE----EYEISALTTKGPVKGA---RKSTIGLKKRP- 165

  Fly   358 VTGPPLGNSLWKLPVRRFHPEYFELI-KRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKA 421
              ..|:...:::..|....|:....| ..|:| :|:..|||.| ....:|.|......:.:.:.:
Zfish   166 --PSPMSEVVFQQTVTVIPPDALHTIPSAPLS-AQLTAKLKNG-VKRKADTTTPSASSIPSCESS 226

  Fly   422 FPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSN 486
            ...:..      |:|||.:                                  :|..|||
Zfish   227 SCVTEP------KVLKLFS----------------------------------RRGSGRP----- 246

  Fly   487 SNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYP---- 547
            ........|   .||..:::.....:.:::    ||.      |....|||.:|.....:|
Zfish   247 IKPPCKDLP---ESPPQHQVGRRTKLSERL----KYC------NAILKEMFSKKHSAYAWPFYKP 298

  Fly   548 ---------DYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDAN 603
                     ||::||..|:||:||:..:....|.......:|.|||||||.:||..|..:...|.
Zfish   299 VDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMAR 363

  Fly   604 ILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITERL--------WQFYETVKEYQEPKG 660
            .|:.....:..:.|...:.......:::|.::...:..:...        ....:|.:|.:|.:.
Zfish   364 KLQDVFEFRFSKIPDEPKNANPVSSHNRVKKERARSPSSSESSDSESSSPENSSDTEEEDEEERA 428

  Fly   661 KR------QLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENA 719
            .|      ||..:..:|...::.|     :.:|...::..:|.|:..               |::
Zfish   429 HRLASLEEQLKAVREQLQLLTQTP-----LLKPKKKEKSKKKKKKER---------------ESS 473

  Fly   720 CKYNEPDSQIYKDALVLQQLTLQLKQQLRTER-----DSLPDVPLAVQELFLTLFTTIYNHQDEE 779
            .:..|   ::.|.|.:|::.:.......:..|     :.:..:|::.                ||
Zfish   474 KRKGE---EMKKPAKILKRSSSSKSSGRKESRACDSEEEMNTLPMSY----------------EE 519

  Fly   780 GRCYSDSLAELPEYDEIGE--------GPKVRG-----ISLDLVKRRLDKGAYKRLDVYQEDIFA 831
            .|..|..:.:||. |::|:        .|.:|.     |.:|.  ..|.....:.|:.|   :..
Zfish   520 KRQLSLDINKLPG-DKLGKVVNIIKAREPLLRDTDPEEIEIDF--ETLKPSTLRALECY---VVG 578

  Fly   832 CLE------------RARKLSRTDSDIFQDSIELQTYFIRK--RDELCKDTLSSSALNFSLERLM 882
            ||.            :..|:...|.|:...:.|..::...|  .|...|||...|.|:.|
Zfish   579 CLRKKTKETNKNKPPKKSKIKEKDKDLQHATGEQNSHKKTKIETDGEIKDTTHPSRLSDS----- 638

  Fly   883 ADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIER 947
                    ............|....:...:..|..|..:|...||.       .|||
Zfish   639 --------SSSSSSSDSSSSDSSSSDSCDSDSEQKTKRKQSKGPGH-------ANKI-------- 680

  Fly   948 LWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMR 1012
                 ..:.|.||:..|:.                 .||.|..:...:...:......||....:
Zfish   681 -----KKKALRQANAEVKD-----------------SSSASGVMCQSRPSSLVSETGSKDLFASQ 723

  Fly  1013 PENLPEKD---VYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPRE-----QPLEL--KRVMSV 1067
            ....|.:|   :....||...|           |.|.......:||:     .||.|  .:.:|.
Zfish   724 HAKHPVEDITAITALHSRLPPQ-----------PSRPSGKAAALPRKIWTTPSPLSLPPDQALSP 777

  Fly  1068 FKERLEKHKGELEELKLQETLVEKEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVAT 1132
            .     .:.......|....:..|..|......|||:......:.     ||..:...|.  ..:
Zfish   778 L-----YNASATSPCKDHTIIPAKSSPESVTPDPPNSLPKDPLFP-----CSPLLPPPDM--QVS 830

  Fly  1133 QTGKQSVAQVQ---QIWEQNGKSYFKGPWLLPPSETTPGLGKQF-----YRQELLLSTVEEVSPV 1189
            |.|..|....:   |..|:.|......| |..||...|..|.|.     :.|..|||.:.| ||:
Zfish   831 QVGPPSSVAAKIPPQKSEKEGIPPLLSP-LTSPSAAMPATGSQSTSSSQFEQCRLLSPLHE-SPL 893

  Fly  1190 VGIVGRCAVLEYSEFISSRPTEIS----------ESDVYICESVYDELKKALRKLVTGNMRKFQH 1244
                   |.:...:.....|.|.|          ..|..:|:|:.|......:|.:.     .:|
Zfish   894 -------ASMRNEQDCPETPEESSVHLHKIHGAKHDDNELCKSIQDAKSNLPKKDIV-----LKH 946

  Fly  1245 SPSVTEDEIFYFKTP--IKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVNSTPLT 1307
            :.|.|.......:||  ||.||:...:..::.|.::..:                  ......|.
Zfish   947 ADSWTSLGKLATQTPCTIKSSKESFQQFRKVAMEKEERE------------------RARKLQLE 993

  Fly  1308 SKVKAAKSAKKCLTGYILYSSEVRKSICQ-SNPDATFGDISRM---VGTEWKNLPSSVKQSWEDR 1368
            :..:.:.:.|.|||    ...:..|..|| |.|:....::..|   :.|.....||||.|:..||
Zfish   994 AGREKSSTDKSCLT----QQPQKAKLECQPSKPEVESAELPLMAAILDTPKAPEPSSVLQNSVDR 1054

  Fly  1369 ---ASRQNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTFE 1408
               .:|:.|:....|..:..|.:..     :.:|:   :.|||
Zfish  1055 EREMARKREQERRRREAMSGVIDMT-----MQRDI---MATFE 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	22/65 (34%)
		Bromo_polybromo_III	335..443	CDD:99951	21/108 (19%)
		Bromo_polybromo_IV	512..613	CDD:99949	31/113 (27%)
		Bromo_polybromo_V	641..733	CDD:99946	14/105 (13%)
		Bromo_polybromo_VI	758..867	CDD:99956	24/135 (18%)
		BAH_polybromo	921..1040	CDD:240068	20/121 (17%)
		BAH_polybromo	1120..1234	CDD:240068	29/131 (22%)
		HMG-box	1320..1375	CDD:238037	17/61 (28%)
brdt	XP_002662470.2	Bromo_Brdt_I_like	29..135	CDD:99929	23/90 (26%)
		Bromo_Brdt_II_like	273..373	CDD:99930	31/109 (28%)
		BET	514..577	CDD:293640	16/84 (19%)
		BRD4_CDT	1050..1093	CDD:293710	10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910