DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and brd3a

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_001116861.1	Gene:	brd3a / 327372	ZFINID:	ZDB-GENE-030131-6141	Length:	683	Species:	Danio rerio

Alignment Length:	880	Identity:	161/880 - (18%)
Similarity:	272/880 - (30%)	Gaps:	352/880 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 PDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQ 292
            |||:.:|::|:|:..|..:::...|.|.:|..:|...|..|..::|:|...|...|::|::||.|
Zfish    67 PDYHKIIKNPMDMGTIKKRLESVYYYSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQ 131

  Fly   293 RRIELEMGKGKLAKRVKSLSSAAIAAL-KEEVDSSDDEETSKKGEGPMWALFDHLYNAPG----- 351
            :                      :|.: :|||:..   ..:.||:|...|       .||
Zfish   132 K----------------------VALMPQEEVELL---PPAPKGKGRKPA-------GPGQQDGA 164

  Fly   352 ------TSEHPGVTGPPLGNSLWK-LPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTA 409
                  ||..||.|.|....::.. .||....|
Zfish   165 VSTGSPTSVFPGATSPSSQTAVVSPAPVPAITP-------------------------------- 197

  Fly   410 DLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPE 474
                       :.|....|           .|..|..|:.                    .:||.
Zfish   198 -----------SIPAVQNT-----------TAAAVIPSMP--------------------PSQPT 220

  Fly   475 KRKPG-RPRINSNSNSNASHTPNNSNSP------KSNRIAINAAIKKKILSIQKYLVDYSLGNRR 532
            .:|.| :.:.::.:.:.::.|.:.|.||      |.:::|....               |.|  |
Zfish   221 VKKKGVKRKADTTTPTTSAITASRSQSPTPILEGKQSKVAARRE---------------STG--R 268

  Fly   533 PIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSN 597
            ||     |||:|
Zfish   269 PI-----KPPKK----------------------------------------------------- 275

  Fly   598 IYEDANILERALNEKLKEFPGLTEGKK----SQQKYSKVGRKLKTAVITERL--------WQFYE 650
            .:||..:             |:..|||    .|.||..|       ::.|.|        |.||:
Zfish   276 DFEDGEL-------------GVHGGKKGRLSEQLKYCDV-------ILKEMLSKKHAAYAWPFYK 320

  Fly   651 TVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLM 715
            .|.                  ....|..||:|||:.|:|:..:.:|:....|......|||..||
Zfish   321 PVD------------------AEALELHDYHDIIKHPMDLSTVKKKMDSREYQDAQTFAADVRLM 367

  Fly   716 LENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEG 780
            ..|..|||.||.::...|..||.:.     ::|..:  :||.|:
Zfish   368 FSNCYKYNPPDHEVVAMARKLQDVF-----EMRFAK--MPDEPV--------------------- 404

  Fly   781 RCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLSRTDSD 845
                    |:|....:| |..|...|....:...|.......|..:       |||.:|:.....
Zfish   405 --------EVPGAGGVG-GAGVVSKSTVSSESSGDSSTSDSSDSEE-------ERATRLAELQEQ 453

  Fly   846 IFQDSIELQTYFIRKRDELCKDTLSSSALNFSLERL----MADVELCRQQKMQQE----EQDQEQ 902
            :..:......:.|..|..:......::.|....|:|    .|.|...:::|.::|    :::.:.
Zfish   454 VGAEQCISLEHPIGSRKGIKNGCTKNNQLKAVHEQLAALSQAPVSKPKKKKEKKEKDKKKKENKH 518

  Fly   903 DKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPH 967
            :|.|.|..|..|:.....||...|.......:|.|:.|     ::....|..|...:.|:.:...
Zfish   519 NKSKPEEKAKPGQPPKPAQQKKGPTRKANSTVPGNRQP-----KKGGRGPGYESDEEMSLPMTYD 578

  Fly   968 ETYHVTTRKFLEKEVFKSSLSQTISM---DKVQGMCYVMNIK--------------DYIKMRPEN 1015
            |               |..||..|:.   :|:..:.:::..:              |:..::|..
Zfish   579 E---------------KRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPST 628

  Fly  1016 LPEKDVYV--CESRYNIQGRWFKKLKSWPPVREGS 1048
            |.|.:.||  |          .:|.:..||.:.||
Zfish   629 LRELERYVKSC----------LQKKQRKPPQKGGS 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	21/65 (32%)
		Bromo_polybromo_III	335..443	CDD:99951	17/119 (14%)
		Bromo_polybromo_IV	512..613	CDD:99949	11/100 (11%)
		Bromo_polybromo_V	641..733	CDD:99946	27/99 (27%)
		Bromo_polybromo_VI	758..867	CDD:99956	15/108 (14%)
		BAH_polybromo	921..1040	CDD:240068	23/137 (17%)
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
brd3a	NP_001116861.1	Bromo_Brdt_I_like	30..136	CDD:99929	22/90 (24%)
		Bromo_Brdt_II_like	295..396	CDD:99930	34/130 (26%)
		BET	574..638	CDD:293640	12/78 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900