DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and Baz1a

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_038968148.1	Gene:	Baz1a / 314126	RGDID:	1306199	Length:	1583	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	141/763 - (18%)
Similarity:	254/763 - (33%)	Gaps:	229/763 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSISSRQDEDPLQLDDSTPEQSPVQQTT-----------------------TQSARKKRRL-DPT 49
            |..:|..|:.|  .|||.....||.:..                       .:||.|:..| :.:
  Rat   864 SESTSSLDQGP--FDDSLLLPKPVHKPNRWCFYSSCEQLDQLIEALNSRGHRESALKETLLQEKS 926

  Fly    50 ELCQQL---------------YDSIRNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVN------- 92
            .:|.||               .|| :.:.....|..|||.....:|:.|....|.:::
  Rat   927 RICAQLAHFSEEKFHFSDKPQADS-KPVSSRGRSAACDTSQMSAERQLELRLRDFLLDIEDRIYQ 990

  Fly    93 -PIDLLKVQQK------LKTDSY-----------------DDLDDLMADLELLIGNAKAFYI--- 130
             .:..:||..:      |:...|                 ||::::..:...:|...:...:
  Rat   991 GTLGAIKVTDRQVWRSALENGRYELLSEESKENGVSKAVNDDVEEMEIEQARVIVRDRLLGLKTE 1055

  Fly   131 -----------PGSSE---HQDAVSLWQHIHSQRQRIMEA----NGLAEEEPRARRMSRQVRRMT 177
                       |.|..   |..|.:|:|......:|.::|    ..:.:::..||:...:.:|..
  Rat  1056 TPSTVSTSTSTPQSVSNVVHYLATALFQIEQGIERRFLKAPLGNTEINKDQKGARKKKNKKKRED 1120

  Fly   178 SSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEH--PIDL 240
            ..:....||:  |....|:.:.           ||...   .||.|..:    ..|..|  .:|.
  Rat  1121 DQSSVRDDGS--DSGRSYKTVL-----------DRWRE---SLLSSASL----SQVFLHLSTLDR 1165

  Fly   241 RLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLA 305
            .::.:|..:||...:...:.|...|.  .|...:.|...|.....||.:........|....:.:
  Rat  1166 SVMWSKSILNARCKICRKKGDAENMV--LCDGCDRGHHTYCVRPKLKTVPDGDWFCPECRPKQRS 1228

  Fly   306 KRVKSLSSAAIAALKE----------EVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTG 360
            :|:.|....::.:.:|          |||..|::..|::.|      ::...:...:.|...::.
  Rat  1229 RRLSSRQRPSLESDEEMEEGMEGDDGEVDDDDEDGQSEEEE------YEVEQDEEDSDEEEALSP 1287

  Fly   361 PPLGNSLWKLPVR---RFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAF 422
            |..|....:||::   ||.|.:       .|.||   :...|.|.:             .::::.
  Rat  1288 PKRGRPQVRLPIKTRGRFGPSF-------SSRSQ---RQDPGRYPS-------------RSQQST 1329

  Fly   423 PTSHRTHKDALKMLKLMNAKLVE-ESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSN 486
            |.:..:......:.|..:|...| .||..||.........:..:||.....|.    |:.|:..:
  Rat  1330 PKTTASKTAGRNLRKTRSAPPTETRSLRLGSRSTRHSPNALQADVFVELLSPR----GKRRVRKS 1390

  Fly   487 SNSNASHTPNNSN------SPKSNRIAINAAIKKKILSIQKYLVDYSLGNRR----------PIE 535
            :::...|:|:.:|      .|....|.:|:|.:   ||:|.     |...||          |:.
  Rat  1391 ADNTPEHSPSLTNLRVSTSRPSVQLIPLNSAER---LSLQD-----SESKRRGRKRQSTESSPVP 1447

  Fly   536 M--------------------------------FMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRT 568
            :                                |::...:...|||||||:.||.:|.|...:..
  Rat  1448 LNRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNK 1512

  Fly   569 DRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEF 616
            ..|....:.:.|..||||||.:||..        |..|.....:|:.|
  Rat  1513 CEYKLASEFIEDIELMFSNCFEYNPR--------NTSEAKAGTRLQAF 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	28/179 (16%)
		Bromo_polybromo_II	191..294	CDD:99948	19/104 (18%)
		Bromo_polybromo_III	335..443	CDD:99951	17/110 (15%)
		Bromo_polybromo_IV	512..613	CDD:99949	31/142 (22%)
		Bromo_polybromo_V	641..733	CDD:99946
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
Baz1a	XP_038968148.1	WAC_Acf1_DNA_bd	23..122	CDD:402251
		DDT	422..483	CDD:214726
		WHIM1	590..635	CDD:406127
		PTZ00121	<646..793	CDD:173412
		WSD	799..925	CDD:406128	13/62 (21%)
		PHD_BAZ1A	1177..1222	CDD:277097	7/46 (15%)
		Bromo_Acf1_like	1449..1562	CDD:99936	26/112 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900