DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and Pbrm1

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:XP_006252748.1 Gene:Pbrm1 / 306254 RGDID:1565549 Length:1726 Species:Rattus norvegicus


Alignment Length:1840 Identity:638/1840 - (34%)
Similarity:955/1840 - (51%) Gaps:325/1840 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLSRKRRASSISSRQDEDPLQLDD---STPEQSPVQQTTTQSARKKRRL------DPTELCQQLY 56
            |.|::|||:|.||....|   .||   |.|...|        :||:|||      ||..:|.:||
  Rat    22 MGSKRRRATSPSSSVSGD---FDDGHHSVPTPGP--------SRKRRRLSSLPTVDPIAVCHELY 75

  Fly    57 DSIRNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELL 121
            ::||:.|.|.|.:||:.|||.||||.:|.||:||..||||:|:|||||.:.|||::.|.||.:||
  Rat    76 NTIRDYKDEQGRLLCELFIRAPKRRNQPDYYEVVSQPIDLMKIQQKLKMEEYDDINLLTADFQLL 140

  Fly   122 IGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDG 186
            ..||||:|.|.|.|::.|..||......|...:: .|.|::|............|...:.||   
  Rat   141 FNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFVQ-KGEADDEDDDEDGQDNQGTMADGSSPG--- 201

  Fly   187 ATDDEYNQ--YEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQM 249
                 |.:  .|:|..:::.||:|.| ||:..:||.||||..|||||.:|:.||||:.||.:||.
  Rat   202 -----YLKEILEQLLEAIVVATNPSG-RLISELFQKLPSKVQYPDYYAIIKEPIDLKTIAQRIQN 260

  Fly   250 NAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIEL---EMGKGKLAKRVKSL 311
            .:|.|:..|.:|:..:.|||..:||||||::|||.|:|:||..::.|:   ||.|..|  |:::.
  Rat   261 GSYKSIHAMAKDIDLLAKNAKTYNEPGSQVFKDANSIKKIFYMKKAEIEHHEMTKSSL--RIRTA 323

  Fly   312 SSAAIAAL------KEEVD------------------------------SSDDEETS-------K 333
            ::.|.|.|      |..:|                              .|:.||.:       :
  Rat   324 TNLAAARLTGPSHNKSSLDEERNPTSKCYRNKRAVQGGRLSAITMALQYGSESEEDAALAAARYE 388

  Fly   334 KGEGPMWAL---------FDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISM 389
            :||....::         |..||:...:..:.  .|..:....:.||.::.:|:|::.||.|||:
  Rat   389 EGESEAESITSFMDVSNPFHQLYDTVRSCRNN--QGQLIAEPFFHLPSKKKYPDYYQQIKMPISL 451

  Fly   390 SQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDL 454
            .||.||||..:|..:..|..||.||.:|||:....:...:|..||:.::|.||..|.:..:    
  Rat   452 QQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVPNSAIYKRVLKLQQVMQAKKKELARRD---- 512

  Fly   455 DDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSI 519
            |.||.:.|.:.. |..|...|||       .|::.:........:|.|.|       |:|:.:  
  Rat   513 DIEDGDSMISSA-TSDTGSAKRK-------RNTHDSEMLGLRRLSSSKKN-------IRKQRM-- 560

  Fly   520 QKYLVDYSLGNRRP------IEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVV 578
             |.|.:..|..|.|      .::||.||.:|.|||||.||..|:|:..||||||.|:||..|.::
  Rat   561 -KILFNVVLEAREPGSGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMM 624

  Fly   579 SDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRK-----LKT 638
            .|.:|||.|.|.||||||.:|.||:|||:.|.:|.||...|.:.........|:.||     .|:
  Rat   625 EDMKLMFRNARHYNEEGSQVYNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKS 689

  Fly   639 AVIT---ERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQG 700
            ..:|   ::|.:.||.||.|.:.:|:| ||.||.:|||:||.||||..|::|:||::|...:...
  Rat   690 KYMTPMQQKLNEVYEAVKNYTDKRGRR-LSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMAN 753

  Fly   701 AYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDS-LPDVPLAVQEL 764
            .|..:|.:..||::|..|||.||||:|.||||||||.::.|:.::.|..:.|| :|:|.|.:|||
  Rat   754 KYQDIDSMVEDFVMMFNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQEL 818

  Fly   765 FLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDI 829
            ...||.::.:|||:|||||||||||:|..|.  ..|....::.|::::.::...|:|||::||.:
  Rat   819 IHNLFVSVMSHQDDEGRCYSDSLAEIPAVDP--NFPSRPPLTFDIIRKNVESNRYRRLDLFQEHM 881

  Fly   830 FACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCK--DTLSSSALNFSLERLMADVELCRQQK 892
            |..|||||:::||||:|::|::|||.:|||.||||||  :.|.|.||:::.:.|..|||..:::|
  Rat   882 FEVLERARRMNRTDSEIYEDAVELQQFFIRIRDELCKNGEILLSPALSYTTKHLHNDVEKEKKEK 946

  Fly   893 MQQEEQDQEQDKEKDEFNAAKGE-----------------SMTINQQVFSPGDYVYVQMPE-NKI 939
            :.:|.::.:..:|:::..|.|.|                 ..:....::..||||||:..| |..
  Rat   947 LPKEIEEDKLKREEEKREAEKSEDSSGTTGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQ 1011

  Fly   940 PSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMN 1004
            |.|.||||||.....||.:....|.||:||:|:.||||||||||||.....:.:.|:.|.|.||.
  Rat  1012 PHIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMF 1076

  Fly  1005 IKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSWP-PVREGSSVKFVPREQPLELKRVMSVF 1068
            :|:|.|:.||...::||:||||||:.:.:.|||:|.|. |:   |||:||||:.||.:.||.|||
  Rat  1077 VKEYFKLCPETFRDEDVFVCESRYSAKTKSFKKIKLWTMPI---SSVRFVPRDVPLPVVRVASVF 1138

  Fly  1069 ----KERLEKHKGELEELKLQETL-VEKEKPNVSCDPPPNAEVGSTYYQQ--YNTICSGAIKTGD 1126
                |...||.....::.:.:::. :||||.:|..: ..|.|.|..|::|  ||.:.   :|.||
  Rat  1139 ANADKGDEEKSTDNSDDNRAEDSFNLEKEKEDVPVE-MSNGEPGCHYFEQLRYNDMW---LKVGD 1199

  Fly  1127 FVYVATQ-TGKQSVAQVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVV 1190
            .|::.:. ..:..|.:::::|.::|.:||.||..:.|.||.....|.||::|:.||.:||..|:.
  Rat  1200 CVFIKSHGLVRPRVGRIEKVWVRDGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMS 1264

  Fly  1191 GIVGRCAVLEYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFY 1255
            .|:|:||||.:.:|:|.|||||.|:|:.:|||.|:|..|.::|.  ..:::|..|..|.:|||:|
  Rat  1265 CILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNESDKQMKKF--KGLKRFSLSAKVVDDEIYY 1327

  Fly  1256 FKTPIKPSK------DFKNELNELGMLE-DSMDGDTPSLSSDIAAMSSP-------APSVNS--- 1303
            |:.||.|.|      :.|.:|.|....| :..|.||..:..:.:.:..|       .|..|.   
  Rat  1328 FRKPIIPQKEPSPLLEKKIQLLEAKFAELEGGDDDTEEMGEEDSEVIEPPSLPQLQTPLANELDL 1392

  Fly  1304 ---TPLTSKVKAAK-SAKK-------CLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNL 1357
               ||..|..|:|| ||||       .::||||:|||:|..|...:||.:||::||:|||||:||
  Rat  1393 MPYTPPQSTPKSAKGSAKKESSKRKINMSGYILFSSEMRAVIKAQHPDYSFGELSRLVGTEWRNL 1457

  Fly  1358 PSSVKQSWEDRASR----QNEETAALRRELDDVQNSASPSS-------------QVSQDVFGQVL 1405
            .::.|..:|:||::    |..|.||.::     |.||||.:             .....:..|.|
  Rat  1458 ETAKKAEYEERAAKAAEQQERERAAQQQ-----QPSASPRAGTPVGALMGVVPPPTPMGMLNQQL 1517

  Fly  1406 TFECQWDKCDFQFEELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLWRNCPRVKKSVQAFPNVLR 1470
            |                                 |.||:...|       |.....:|...:.|.
  Rat  1518 T---------------------------------PVAGMMGGY-------PPGLPPLQGPVDGLV 1542

  Fly  1471 LIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQQQQ 1535
            .:..::.:|                  |.......|...||..|.:  .|....|.....:....
  Rat  1543 SMGSMQPLH------------------PGGPPPHHLPPGVPGLPGI--PPPGVMNQGVTPMVGTP 1587

  Fly  1536 HPQQNMHQLQQQQTIVLGPPPE----------------------PLFVTVPPRTTRVIHSEAYIK 1578
            .|..:.:   .||..|||||.:                      |:||..||:|.|::|||||:|
  Rat  1588 APGGSPY---GQQVGVLGPPGQQAPPPYPGPHPTGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLK 1649

  Fly  1579 YIESLQTGSHLNVVTCNNNW------RRALTHITPAQVVAKTALPEKWIGPNLRDQG---NVVQA 1634
            |||.|...|  |.:   :.|      ||...|::..|   ::.||..|    |:.:|   .:..|
  Rat  1650 YIEGLSAES--NSI---SKWDQTLAARRRDVHLSKEQ---ESRLPSHW----LKSKGAHTTMADA 1702

  Fly  1635 LCHLRNFMVDDILQIRRSCN 1654
            |..||:.|:.|.|.||::.|
  Rat  1703 LWRLRDLMLRDTLNIRQAYN 1722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 55/117 (47%)
Bromo_polybromo_II 191..294 CDD:99948 49/104 (47%)
Bromo_polybromo_III 335..443 CDD:99951 35/116 (30%)
Bromo_polybromo_IV 512..613 CDD:99949 50/106 (47%)
Bromo_polybromo_V 641..733 CDD:99946 43/94 (46%)
Bromo_polybromo_VI 758..867 CDD:99956 54/110 (49%)
BAH_polybromo 921..1040 CDD:240068 57/119 (48%)
BAH_polybromo 1120..1234 CDD:240068 44/114 (39%)
HMG-box 1320..1375 CDD:238037 27/58 (47%)
Pbrm1XP_006252748.1 Bromo_polybromo_I 65..177 CDD:99954 54/112 (48%)
Bromo_polybromo_II 203..305 CDD:99948 48/102 (47%)
Bromo_polybromo_III 404..505 CDD:99951 33/102 (32%)
Bromo_polybromo_IV 556..659 CDD:99949 49/105 (47%)
Bromo_polybromo_V 695..799 CDD:99946 48/104 (46%)
Bromo_polybromo_VI 812..919 CDD:99956 53/108 (49%)
BAH_polybromo 994..1111 CDD:240068 57/116 (49%)
BAH_polybromo 1192..1310 CDD:240068 45/122 (37%)
HMG-box 1417..1481 CDD:238037 28/63 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340678
Domainoid 1 1.000 121 1.000 Domainoid score I5598
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10044
Inparanoid 1 1.050 952 1.000 Inparanoid score I318
OMA 1 1.010 - - QHG52483
OrthoDB 1 1.010 - - D168080at2759
OrthoFinder 1 1.000 - - FOG0002672
OrthoInspector 1 1.000 - - oto97303
orthoMCL 1 0.900 - - OOG6_103614
Panther 1 1.100 - - LDO PTHR16062
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2912
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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