DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and brd2a

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_571275.2	Gene:	brd2a / 30445	ZFINID:	ZDB-GENE-990415-248	Length:	836	Species:	Danio rerio

Alignment Length:	998	Identity:	196/998 - (19%)
Similarity:	337/998 - (33%)	Gaps:	331/998 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 EPRARRMSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTAT----------DPVGDRLMHRM 217
            :|..|..||| .|||               ||.:.|..:::...          :||.
Zfish    61 QPAVRDPSRQ-GRMT---------------NQLQFLQKALVKTLWRHHFAWPFHEPVD------- 102

  Fly   218 FQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKD 282
                .:|...||||::|:.|:|:..|..:::.|.|.|.:|..:|...|..|..::|:|...|...
Zfish   103 ----AAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLM 163

  Fly   283 AKSLKRIFTQR-----RIELEM------GKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGE 336
            |:||::.|.|:     .:|.|:      ||....|:.:.|.|..|....:.
Zfish   164 AQSLEKAFLQKVAQMPEVEEEIPAPVPRGKQSKPKKGQKLFSGGITTAHQV-------------- 214

  Fly   337 GPMWALFDHLYNAPGTSEHPG--VTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKG 399
             |..:....|..:|.|.:.|.  ::.||     ..|..:.|.|.........:.:.......||.
Zfish   215 -PAISSLSQLAYSPPTPDTPDSVLSTPP-----QTLITKNFPPPPLHSTPALLGLPPTQPTAKKK 273

  Fly   400 DYANISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDT 464
            .....:|.|.             ||:           .:|...|....:..|..:.......|.
Zfish   274 GVKRKADTTT-------------PTT-----------TVMPLTLGVGGMGMGMGMGMSMGMGMG- 313

  Fly   465 EVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLG 529
                              :....:|..:.:....:|.:|..:::..:::.|:.:.:.       |
Zfish   314 ------------------MGLGGDSPLTLSNMGMDSKQSLSLSLGMSLEDKVPARRG-------G 353

  Fly   530 NRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEE 594
            :.|||     |||||..||    .||       :|.
Zfish   354 SGRPI-----KPPRKDLPD----SQN-------QHQ----------------------------- 373

  Fly   595 GSNIYEDANILERALNEKLKEFPGLTEGKKSQQ-KY-SKVGRKLKTAVITERLWQFYETVKEYQE 657
                                   .:..||.||| :| |.:.::|.:...|...|.||       :
Zfish   374 -----------------------PVRRGKLSQQLRYCSTILKELLSKKHTAYAWPFY-------K 408

  Fly   658 PKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKY 722
            |.....|.|           .||||||..|:|:..|.:|:....|......|||..||..|..||
Zfish   409 PVDVSSLGL-----------HDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKY 462

  Fly   723 NEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSL 787
            |.||..:...|..||.:.     :.|..:  :||.|                            |
Zfish   463 NPPDHDVVAMARRLQDVF-----EFRFAK--MPDEP----------------------------L 492

  Fly   788 AELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIE 852
            ..||.....|      |:..|.........:....||..|            |.::|....||.|
Zfish   493 ESLPPASLGG------GLGGDSSSSSSSSSSSSESDVSSE------------SESESSPSSDSEE 539

  Fly   853 LQTYFIRK-RDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGES 916
            .:.:.:.: ::::|...   .|::..|..|.:...:  :.|.::|::|:::.|:.::..  :..|
Zfish   540 ERAHRLAQLQEQVCTQL---RAVHEQLAALSSTPII--KPKKKKEKKDKKKKKKPEKHK--RSRS 597

  Fly   917 MTINQQVFSPGDYVYVQMPE-NKIPSICCIERLWTSPTNE-------------KLMQASIFVRPH 967
            :..::.|..|     .::|: .|.|......:..||..::             |..|.:.|..|.
Zfish   598 VIEDEVVMRP-----AKIPKLPKTPKSRSNSKAATSTQSKKSSNKKSNKSKSSKKAQPTFFPPPL 657

  Fly   968 ETYHVTTRKFLEKEVFKSSLS----QTISMD-------KVQGMCYVMNIK--------------D 1007
            ....:|.....|:|...|.:|    :.:|:|       |:..:.:::..:              |
Zfish   658 SHSGLTPHYDSEEEEETSPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDTNPEEIEID 722

  Fly  1008 YIKMRPENLPEKDVYV--CESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQ-PLELKRVMSVFK 1069
            :..::|..|.|.:.||  |..:        |..|.:..:: ||:.|  .||: .||.||.:   :
Zfish   723 FETLKPSTLRELERYVMMCLRK--------KPRKPFVAIK-GSAGK--SREELALEKKREL---E 773

  Fly  1070 ERLEKHKGELEELKL-QETLVEK 1091
            .||:...|:|..:|. |:|..||
Zfish   774 RRLQDVSGQLNSVKKPQKTKAEK 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	29/117 (25%)
		Bromo_polybromo_III	335..443	CDD:99951	17/109 (16%)
		Bromo_polybromo_IV	512..613	CDD:99949	15/100 (15%)
		Bromo_polybromo_V	641..733	CDD:99946	29/91 (32%)
		Bromo_polybromo_VI	758..867	CDD:99956	16/109 (15%)
		BAH_polybromo	921..1040	CDD:240068	27/159 (17%)
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
brd2a	NP_571275.2	Bromo_Brdt_I_like	72..178	CDD:99929	32/131 (24%)
		Bromo_Brdt_II_like	383..484	CDD:99930	36/123 (29%)
		BET	676..738	CDD:293640	8/61 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810