DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and Brd2

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_997660.1	Gene:	Brd2 / 294276	RGDID:	1303324	Length:	798	Species:	Rattus norvegicus

Alignment Length:	1042	Identity:	206/1042 - (19%)
Similarity:	350/1042 - (33%)	Gaps:	362/1042 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 LIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMS--RQVRRMTSSTEPG 183
            |:|.......||....:.:: |::...|.....:.|..||...|....:|  ::..|:|
  Rat    18 LLGLGPEAAAPGKRIRKPSL-LYEGFESPTMASVPALQLAPANPPPPEVSNPKKPGRVT------ 75

  Fly   184 GDGATDDEYNQYEELFASVMTATDPVGDRLMHRMF-----QLLPSKKI-YPDYYDVIEHPIDLRL 242
                     ||.:.|...||.|       |....|     |.:.:.|: .|||:.:|:.|:|:..
  Rat    76 ---------NQLQYLHKVVMKA-------LWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT 124

  Fly   243 IATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKR 307
            |..:::.|.|.:.:|..:|...|..|..::|:|...|...|::|::||.|:...:...:.:|...
  Rat   125 IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVT 189

  Fly   308 VKSLS---SAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTGPP--LGNSL 367
            :...|   .|.:|||:..:.|:                  |...|..:..|..:..||  :..::
  Rat   190 IPKNSHKKGAKLAALQGSITSA------------------HQVPAVSSVSHTALYTPPPEIPTTV 236

  Fly   368 WKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHKDA 432
            ..:|    ||   .:|..|: :..:|:             .....|.:..|..|.|.:.:
  Rat   237 LNIP----HP---SVISSPL-LKSLHS-------------AGPPLLAVSAAPPAQPLAKK----- 275

  Fly   433 LKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNN 497
             |.:|                      .:.||   |..|......||.|.           :|..
  Rat   276 -KGVK----------------------RKADT---TTPTPTAILAPGSPA-----------SPPG 303

  Fly   498 SNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTI 562
            |..||:.|:   ..::::              :.|||     |||||..||           :..
  Rat   304 SLEPKAARL---PPMRRE--------------SGRPI-----KPPRKDLPD-----------SQQ 335

  Fly   563 EHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEG--KKS 625
            :|                         |.:::|.            |:|:||...|:.:.  .|.
  Rat   336 QH-------------------------QSSKKGK------------LSEQLKHCNGILKELLSKK 363

  Fly   626 QQKYSKVGRKLKTAVITERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDM 690
            ...|:               |.||       :|.....|.|           .||:|||:.|:|:
  Rat   364 HAAYA---------------WPFY-------KPVDASALGL-----------HDYHDIIKHPMDL 395

  Fly   691 DRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLP 755
            ..:.:|::...|....:.|||..||..|..|||.||..:...|..||.:.     :.|..:  :|
  Rat   396 STVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF-----EFRYAK--MP 453

  Fly   756 DVPLAVQELFLT------LFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRL 814
            |.||....|.::      |..:......||....|.| .|..|.||  |..:....|.|..:.|.
  Rat   454 DEPLEPGPLPVSTALPPGLAKSSSESSSEESSSESSS-EEEEEEDE--EDEEEESESSDSEEERA 515

  Fly   815 DKGAYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNFSLE 879
                 .||...||.:.|..|:...||       |..|....   |||::
  Rat   516 -----HRLAELQEQLRAVHEQLAALS-------QGPISKPK---RKREK---------------- 549

  Fly   880 RLMADVELCRQQKMQQ-------EEQDQE-------QDKEKDEFNAAKGESMTINQQVF--SPGD 928
                 .|..:::|.::       :|.|:.       |.|:..:.......:.|::...|  |.|.
  Rat   550 -----KEKKKKRKAEKHRGRIGIDEDDKGPRAPRPLQPKKSKKAGGGGSNATTLSHPGFGTSAGS 609

  Fly   929 YVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRP-----HETYHVTTRKFLEKEVFKSSLS 988
                   .||:|              :|..:.:..|.|     .|........:.||......::
  Rat   610 -------SNKLP--------------KKAQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLDIN 653

  Fly   989 QTISMDKVQGMCYVMNIK--------------DYIKMRPENLPEKDVYVCESRYNIQGRWFKKLK 1039
            : :..:|:..:.:::..:              |:..::|..|.|.:.||.
  Rat   654 K-LPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVL--------------- 702

  Fly  1040 SWPPVREGSSVKFVPREQPLELKRVMSVFKER--LEKHKGELEELKLQETLVEKEKPNVSCDPPP 1102
                    |.::..|| :|..:::.:...||.  ||| |.|||: :||:.   ..:.|.:..||.
  Rat   703 --------SCLRKKPR-KPYTIRKPVGKTKEELALEK-KRELEK-RLQDV---SGQLNSTKKPPK 753

  Fly  1103 NA 1104
            .|
  Rat   754 KA 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	7/36 (19%)
		Bromo_polybromo_II	191..294	CDD:99948	31/108 (29%)
		Bromo_polybromo_III	335..443	CDD:99951	17/109 (16%)
		Bromo_polybromo_IV	512..613	CDD:99949	15/100 (15%)
		Bromo_polybromo_V	641..733	CDD:99946	26/91 (29%)
		Bromo_polybromo_VI	758..867	CDD:99956	29/114 (25%)
		BAH_polybromo	921..1040	CDD:240068	19/139 (14%)
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
Brd2	NP_997660.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		4/18 (22%)
		Bromo_Brdt_I_like	73..179	CDD:99929	33/127 (26%)
		PHA03247	<215..332	CDD:223021	36/201 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		30/192 (16%)
		Bromo_Brdt_II_like	348..449	CDD:99930	34/138 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..648		48/252 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		0/3 (0%)
		BET	639..701	CDD:407211	7/62 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..798		7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910