Protein Alignment polybromo and rsc1

DIOPT Version :10

• Sequence 1: NP_651288.1
• Gene: polybromo / 42954
• FlyBaseID: FBgn0039227
• Length: 1654
• Species: Drosophila melanogaster
• Sequence 2: NP_596420.1
• Gene: rsc1 / 2540749
• PomBaseID: SPBC4B4.03
• Length: 803
• Species: Schizosaccharomyces pombe
• Alignment Length: 1033
• Identity: 203/1033 - (19%)
• Similarity: 345/1033 - (33%)
• Gaps: 343/1033 - (33%)

  Fly   385 RPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFP-TSHRTHKDALKMLKLMNAKLVEESL 448
            ||.::..|.:|:.:..|.:.|:..:||..:..|.|..:. |...:...||:...:...:..:
pombe    57 RPTTLKSIQSKIDEFQYHDFSEFVSDLAYLFINVKALYEGTQTYSFVQALEEFCIQQLRTFQ--- 118

  Fly   449 EEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIK 513
            ::|              ...|.|.|....|     ::.::|..|..|..|.||.:.
pombe   119 QQG--------------YIPVITWPNTDSP-----SATTSSPISRNPEYSVSPPNG--------- 155

  Fly   514 KKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVV 578
                  .|::                    |...:.||                :|.|...||..
pombe   156 ------SKFV--------------------KNEDEAYD----------------SDLYVEEEDSD 178

  Fly   579 SDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITE 643
            ...|.|.....:|..|        ::..|.|....|....|               :.:..||..
pombe   179 VKGRSMVGRDGRYKSE--------DLKRRKLQPSSKPLSSL---------------EARAKVIMR 220

  Fly   644 RLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDL 708
            :       |:.|::..| |||...|.:||....:|:||..|.:|:.::.|.:||.:..|:|::..
pombe   221 Q-------VRRYRDGSG-RQLFAPFERLPDPRMFPEYYQAIEQPMALEVIQKKLSKHRYETIEQF 277

  Fly   709 AADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIY 773
            ..||.||.:||..:|:|.||:|:||..|              ::.|.||
pombe   278 VDDFNLMFDNAKSFNDPSSQVYRDADFL--------------KNYLADV---------------- 312

  Fly   774 NHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARK 838
                                                  .||:.|
pombe   313 --------------------------------------LRLEAG--------------------- 318

  Fly   839 LSRTDSDIFQ---DSIELQTYFIRKRDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQ 900
              :.||:.|.   ||        |...:|.|:                |::
pombe   319 --KLDSEFFNYETDS--------RASPQLPKN----------------DIQ-------------- 343

  Fly   901 EQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMP-ENKIPSICCIERLWTSPTNEKLMQASIFV 964
                          .:::|:..:.:.||:|.::.| ::..|.:..|.|:|.|..:...:....::
pombe   344 --------------PAVSIDGTLLNVGDWVLIRNPADSSKPIVSQIYRIWKSDDDINYVTVCWYL 394

  Fly   965 RPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYN 1029
            ||.:|.|.....|.|.||||:||.:...:.::.|.|:||.|..||:.||:.:....|:|||||||
pombe   395 RPEQTVHRADAVFYENEVFKTSLYRDHPVSEIVGRCFVMYITRYIRGRPKGIRSTPVFVCESRYN 459

  Fly  1030 IQGRWFKKLKSW----PPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVE 1090
            ...:.|.|:|||    |....||..:.:..::|:.|.:|.|.....|......|......::...
pombe   460 DDTKQFSKIKSWKACMPQEVSGSEYEMILFDRPITLTKVASPLLHLLASKSQGLPSPATTDSNTH 524

  Fly  1091 KEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFV--------------YVATQTGKQSVAQ 1141
            ......|..||  :.:..|  :.::|..|..:.|.|..              ..|.:|...|...
pombe   525 MLPSQGSLLPP--SSISET--KSFSTKASTPLSTDDIATPLSSAPNPPSVMPTYARKTSSHSERS 585

  Fly  1142 VQQIWEQNG---KSYFKGPWLLPPSE-TTPGLGKQFYRQELLLSTV------EEVSPVVGIVGRC 1196
            ....:..:.   .:.|..|.:...:: |:|...:.||.|...|.::      .::|.  |..||.
pombe   586 SHSSYHNSSHVPTAAFNSPIMRTSTKSTSPIPARPFYAQSGSLQSLNTTQHSHQISG--GHSGRM 648

  Fly  1197 ----AVLEYSEF----------ISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKF-QHSP 1246
                |.|.|:..          ||...|.::...:....|: .....|.  :|.|..:|. :.||
pombe   649 NVPYAKLSYTSHNGRHGGSNGNISGAKTPMTNYTINSMPSL-PVFPPAF--IVPGTHQKLDESSP 710

  Fly  1247 SVTEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVN-STPLTSKV 1310
            ....|::....|......|.....|.|......:|               |.|..| :..||..|
pombe   711 VPGIDDVTVINTETAKMLDKDEHQNVLWYTVPPLD---------------PIPLENRNGSLTHSV 760

  Fly  1311 KAAKSAKKCLTGYILY----SSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQS 1364
            :           |:||    .|:|.....:||      ::||  ..:::||.:|:..:
pombe   761 E-----------YVLYKKSKGSQVITEKARSN------ELSR--EAKFENLVASLSDA 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:445827
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951	13/58 (22%)
		Bromo_polybromo_IV	512..613	CDD:99949	14/100 (14%)
		Bromo_polybromo_V	641..733	CDD:99946	31/91 (34%)
		Bromo_polybromo_VI	758..867	CDD:99956	10/111 (9%)
		BAH_polybromo	921..1040	CDD:240068	40/119 (34%)
		BAH_polybromo	1120..1234	CDD:240068	25/151 (17%)
		HMG-box_PB1	1319..1376	CDD:438800	12/50 (24%)
rsc1	NP_596420.1	BROMO	11..117	CDD:197636	13/59 (22%)
		COG5076	66..447	CDD:227408	118/627 (19%)