DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and rsc1

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_596420.1	Gene:	rsc1 / 2540749	PomBaseID:	SPBC4B4.03	Length:	803	Species:	Schizosaccharomyces pombe

Alignment Length:	1031	Identity:	203/1031 - (19%)
Similarity:	344/1031 - (33%)	Gaps:	339/1031 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 RPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFP-TSHRTHKDALKMLKLMNAKLVEESL 448
            ||.::..|.:|:.:..|.:.|:..:||..:..|.|..:. |...:...||:...:...:..:
pombe    57 RPTTLKSIQSKIDEFQYHDFSEFVSDLAYLFINVKALYEGTQTYSFVQALEEFCIQQLRTFQ--- 118

  Fly   449 EEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIK 513
            ::|              ...|.|.|....|     ::.::|..|..|..|.||.:.
pombe   119 QQG--------------YIPVITWPNTDSP-----SATTSSPISRNPEYSVSPPNG--------- 155

  Fly   514 KKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVV 578
                  .|::                    |...:.||                :|.|...||..
pombe   156 ------SKFV--------------------KNEDEAYD----------------SDLYVEEEDSD 178

  Fly   579 SDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITE 643
            ...|.|.....:|..|        ::..|.|....|....|               :.:..||..
pombe   179 VKGRSMVGRDGRYKSE--------DLKRRKLQPSSKPLSSL---------------EARAKVIMR 220

  Fly   644 RLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDL 708
            :       |:.|::..| |||...|.:||....:|:||..|.:|:.::.|.:||.:..|:|::..
pombe   221 Q-------VRRYRDGSG-RQLFAPFERLPDPRMFPEYYQAIEQPMALEVIQKKLSKHRYETIEQF 277

  Fly   709 AADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIY 773
            ..||.||.:||..:|:|.||:|:||..|              ::.|.||
pombe   278 VDDFNLMFDNAKSFNDPSSQVYRDADFL--------------KNYLADV---------------- 312

  Fly   774 NHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARK 838
                                                  .||:.|
pombe   313 --------------------------------------LRLEAG--------------------- 318

  Fly   839 LSRTDSDIFQ---DSIELQTYFIRKRDELCKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQ 900
              :.||:.|.   ||        |...:|.|:                |::
pombe   319 --KLDSEFFNYETDS--------RASPQLPKN----------------DIQ-------------- 343

  Fly   901 EQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMP-ENKIPSICCIERLWTSPTNEKLMQASIFV 964
                          .:::|:..:.:.||:|.::.| ::..|.:..|.|:|.|..:...:....::
pombe   344 --------------PAVSIDGTLLNVGDWVLIRNPADSSKPIVSQIYRIWKSDDDINYVTVCWYL 394

  Fly   965 RPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYN 1029
            ||.:|.|.....|.|.||||:||.:...:.::.|.|:||.|..||:.||:.:....|:|||||||
pombe   395 RPEQTVHRADAVFYENEVFKTSLYRDHPVSEIVGRCFVMYITRYIRGRPKGIRSTPVFVCESRYN 459

  Fly  1030 IQGRWFKKLKSW----PPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVE 1090
            ...:.|.|:|||    |....||..:.:..::|:.|.:|.|.....|......|......::...
pombe   460 DDTKQFSKIKSWKACMPQEVSGSEYEMILFDRPITLTKVASPLLHLLASKSQGLPSPATTDSNTH 524

  Fly  1091 KEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFV--------------YVATQTGKQSVAQ 1141
            ......|..||  :.:..|  :.::|..|..:.|.|..              ..|.:|...|...
pombe   525 MLPSQGSLLPP--SSISET--KSFSTKASTPLSTDDIATPLSSAPNPPSVMPTYARKTSSHSERS 585

  Fly  1142 VQQIWEQNG---KSYFKGPWLLPPSE-TTPGLGKQFYRQE---LLLSTVEEVSPVV-GIVGRC-- 1196
            ....:..:.   .:.|..|.:...:: |:|...:.||.|.   ..|:|.:....:. |..||.
pombe   586 SHSSYHNSSHVPTAAFNSPIMRTSTKSTSPIPARPFYAQSGSLQSLNTTQHSHQISGGHSGRMNV 650

  Fly  1197 --AVLEYSEF----------ISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKF-QHSPSV 1248
              |.|.|:..          ||...|.::...:....|: .....|.  :|.|..:|. :.||..
pombe   651 PYAKLSYTSHNGRHGGSNGNISGAKTPMTNYTINSMPSL-PVFPPAF--IVPGTHQKLDESSPVP 712

  Fly  1249 TEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVN-STPLTSKVKA 1312
            ..|::....|......|.....|.|......:|               |.|..| :..||..|:
pombe   713 GIDDVTVINTETAKMLDKDEHQNVLWYTVPPLD---------------PIPLENRNGSLTHSVE- 761

  Fly  1313 AKSAKKCLTGYILY----SSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQS 1364
                      |:||    .|:|.....:||      ::||  ..:::||.:|:..:
pombe   762 ----------YVLYKKSKGSQVITEKARSN------ELSR--EAKFENLVASLSDA 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951	13/58 (22%)
		Bromo_polybromo_IV	512..613	CDD:99949	14/100 (14%)
		Bromo_polybromo_V	641..733	CDD:99946	31/91 (34%)
		Bromo_polybromo_VI	758..867	CDD:99956	10/111 (9%)
		BAH_polybromo	921..1040	CDD:240068	40/119 (34%)
		BAH_polybromo	1120..1234	CDD:240068	25/149 (17%)
		HMG-box	1320..1375	CDD:238037	12/49 (24%)
rsc1	NP_596420.1	BROMO	11..117	CDD:197636	13/59 (22%)
		COG5076	66..447	CDD:227408	118/627 (19%)
		Bromo_Rsc1_2_II	211..312	CDD:99953	37/137 (27%)
		BAH_polybromo	350..470	CDD:240068	40/119 (34%)
		Nudix_Hydrolase	688..>782	CDD:294304	26/128 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2323
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002672
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103614
Panther	1	1.100	-	-	LDO	PTHR16062
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11130
SonicParanoid	1	1.000	-	-		X2912
TreeFam	0	0.000	Not matched by this tool.
	7	6.930