DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and BRD4

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_001366220.1	Gene:	BRD4 / 23476	HGNCID:	13575	Length:	1362	Species:	Homo sapiens

Alignment Length:	1450	Identity:	254/1450 - (17%)
Similarity:	430/1450 - (29%)	Gaps:	549/1450 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 KLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTP----NN 497
            :|.|..::.:.||         ..:|.|.......||             :|:.:::.|    :|
Human    10 RLRNLPVMGDGLE---------TSQMSTTQAQAQPQP-------------ANAASTNPPPPETSN 52

  Fly   498 SNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTI 562
            .|.||.....:...::..:.::.|:  .::...::|::..     :...||||.||:.|:||.||
Human    53 PNKPKRQTNQLQYLLRVVLKTLWKH--QFAWPFQQPVDAV-----KLNLPDYYKIIKTPMDMGTI 110

  Fly   563 EHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFP---------- 617
            :..:..:.|...::.:.|:..||:||..||:.|.:|...|..||:...:|:.|.|
Human   111 KKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQ 175

  Fly   618 --GLTEGKKS------------------------------------------------------- 625
              |...|:|.
Human   176 AKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMT 240

  Fly   626 ---------------------------------------QQKYSKVGRKLKTAVI---------- 641
                                                   |...:|.|.|.|....
Human   241 VVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHE 305

  Fly   642 ---------TERLWQFYETVKEYQEPK----GKRQ--------------------LSLIFTKLPS 673
                     |.:|.|..|:.:..:.||    ..:|                    |..:|.|..:
Human   306 PPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHA 370

  Fly   674 KSEYP-------------DYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEP 725
            ...:|             ||.|||:.|:||..|..||:...|....:..||..||..|..|||.|
Human   371 AYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPP 435

  Fly   726 DSQIYKDALVLQQLTLQLKQQLRTERDSLPDVP----LAVQELFLTLFTTIY---NHQDEEGRCY 783
            |.::...|..||.:.     ::|..:  :||.|    :||....:...|.:.   :..|......
Human   436 DHEVVAMARKLQDVF-----EMRFAK--MPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSS 493

  Fly   784 SDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLS-------- 840
            |||.:...:.:|               :|.      :||...||.:.|..|:...||
Human   494 SDSDSSTDDSEE---------------ERA------QRLAELQEQLKAVHEQLAALSQPQQNKPK 537

  Fly   841 RTDSDIFQDSIELQTYFIRKRDELCKDTLSSSAL----------NFSLERLMADVELCRQQKMQQ 895
            :.:.|..:...|.     .||.|..::...|.|.          |.|...:........:.|...
Human   538 KKEKDKKEKKKEK-----HKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPP 597

  Fly   896 EEQDQEQDKEKD-EFNAAKGESMTINQQVFSPGDYV--YVQMPENKIPSICCIERLWTSPTNEKL 957
            ..:.:|:||.|. .:...:..|:.||:   .||:.:  .|.:.:::.||:          .|...
Human   598 TYESEEEDKCKPMSYEEKRQLSLDINK---LPGEKLGRVVHIIQSREPSL----------KNSNP 649

  Fly   958 MQASIFVRPHETYHVTTRKFLEKEVF----KSSLSQTISMDKVQGMCYVMNIKDYIKMRPENLPE 1018
            .:..|   ..||...:|.:.||:.|.    |....|...:|.:.|.   ..:|.:.....|:..|
Human   650 DEIEI---DFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGS---SKMKGFSSSESESSSE 708

  Fly  1019 KDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELK 1083
                                 |.....|.|..:..|:.     |:.....:|:.:.|....::::
Human   709 ---------------------SSSSDSEDSETEMAPKS-----KKKGHPGREQKKHHHHHHQQMQ 747

  Fly  1084 LQETLVEKEKPNVSCDPPPNAEVGS-----------TYYQQYNTICSGAIKTGDFVYVATQTGKQ 1137
            .....|.::.|.....|||......           :..||    .:.|:|:....::|||....
Human   748 QAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQ----AAPAMKSSPPPFIATQVPVL 808

  Fly  1138 SVAQVQQIWEQNGKSYFKGPWL-LPPSETTPGLGKQFYRQELLLSTVEEVSPVVGIVGRCAVLEY 1201
            .......:::..|  :|..|.| ||..|..|.|.:               .|           |:
Human   809 EPQLPGSVFDPIG--HFTQPILHLPQPELPPHLPQ---------------PP-----------EH 845

  Fly  1202 SEFISSRPTEISESDVYICESVYDELKKALRK-------LVTGNMRKFQHSPSVTEDEIFYFKTP 1259
                 |.|..:::..|....::::.|.:...:       |.....|....||::|:       ||
Human   846 -----STPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQ-------TP 898

  Fly  1260 IKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMSSPAPSVNS----------------TPLTS 1308
            :.|..........|  |||.               ..|||.:.|                |||..
Human   899 LLPQPPMAQPPQVL--LEDE---------------EPPAPPLTSMQMQLYLQQLQKVQPPTPLLP 946

  Fly  1309 KVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWEDRASRQN 1373
            .||.                       ||.|...              ||.....|.:.:..:|.
Human   947 SVKV-----------------------QSQPPPP--------------LPPPPHPSVQQQLQQQP 974

  Fly  1374 EETAALRRELDDVQNSASPSSQVSQDVFGQVLTFECQWDKCDFQFEELSDCTEHC--MSDSTGHI 1436
            ......:.:....|....|...|                              |.  |..|| ||
Human   975 PPPPPPQPQPPPQQQHQPPPRPV------------------------------HLQPMQFST-HI 1008

  Fly  1437 QR----------HPQAG--------VETEYVCLWRNCPRVKKSVQAFPNVLRLIKHVREVHLSKC 1483
            |:          ||..|        .:.:.|....:.||..||.......||.......:|..:.
Human  1009 QQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQM 1073

  Fly  1484 GKTISAADRS---KNFVPRRQK--------------------HAQLATTVPIPPSL-AQSPRAPS 1524
            .:..|...:|   :|..|::|:                    |:.:..:.|..||| .:.|:.|.
Human  1074 SQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPE 1138

  Fly  1525 NLEA-VQLQQQ-------------QHPQQNMHQLQQQQTIVLGPPP----------EPLFVTVPP 1565
            :::| |.|.|:             :.|:||            .|||          ||.....|.
Human  1139 SIKAPVHLPQRPEMKPVDVGRPVIRPPEQN------------APPPGAPDKDKQKQEPKTPVAPK 1191

  Fly  1566 RTTRVIHSEAYIKYIESLQT 1585
            :..::.:..::...::...|
Human  1192 KDLKIKNMGSWASLVQKHPT 1211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951	2/5 (40%)
		Bromo_polybromo_IV	512..613	CDD:99949	26/100 (26%)
		Bromo_polybromo_V	641..733	CDD:99946	33/147 (22%)
		Bromo_polybromo_VI	758..867	CDD:99956	23/123 (19%)
		BAH_polybromo	921..1040	CDD:240068	20/124 (16%)
		BAH_polybromo	1120..1234	CDD:240068	20/121 (17%)
		HMG-box	1320..1375	CDD:238037	7/54 (13%)
BRD4	NP_001366220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		13/69 (19%)
		Bromo_Brdt_I_like	58..164	CDD:99929	27/112 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..229		3/54 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..352		12/109 (11%)
		Bromo_Brdt_II_like	353..454	CDD:99930	29/105 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..615		31/177 (18%)
		NPS region	484..503		4/18 (22%)
		BID region	524..579		10/59 (17%)
		BET	609..673	CDD:407211	16/79 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..1100		95/583 (16%)
		PRK03427	<809..>922	CDD:235124	29/169 (17%)
		C-terminal (CTD) region	1047..1362		31/176 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1339		20/107 (19%)
		BRD4_CDT	1319..1362	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810