DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and Baz1b

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_035844.2 Gene:Baz1b / 22385 MGIID:1353499 Length:1479 Species:Mus musculus


Alignment Length:1706 Identity:317/1706 - (18%)
Similarity:556/1706 - (32%) Gaps:605/1706 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 LIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEE-EPRARRMSRQVRRMTSSTEPGG 184
            |.|....|.||               |:|     ||....|| |.|..|.|.::....|:   |.
Mouse    16 LPGEEPLFTIP---------------HTQ-----EAFRTREEYEARLERYSERIWTCKST---GS 57

  Fly   185 DGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQM 249
            ...|..|..:.|:..|.::                    |:.:|::|:        :|:...:..
Mouse    58 SQLTHKEAWEEEQEVAELL--------------------KEEFPNWYE--------KLVLEMVHH 94

  Fly   250 NAYSSLAEMERDLLQ-MTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAK----RVK 309
            |..|....::...|: |||.|                     .....:.|:||.|:.|    ::.
Mouse    95 NTASLEKLVDSAWLEIMTKYA---------------------VGEECDFEVGKEKMLKVKIVKIH 138

  Fly   310 SLSSAAIAALKEEVD------SSDDEETS------------------------------------ 332
            .|......|::::.|      |||.|.:|                                    
Mouse   139 PLEKVDEEAVEKKSDGACDSPSSDKENSSQMAQDLQKKETVVKEDEGRRESINDRARRSPRKLPT 203

  Fly   333 --KKGEGPMWA---LFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQI 392
              |||| ..||   ...|.|:....:|...::..| .:||    :|...|...|:::..|.    
Mouse   204 SLKKGE-RKWAPPKFLPHKYDVKLQNEDKIISNVP-ADSL----IRTERPPNKEILRYFIR---- 258

  Fly   393 HTKLKKGDYAN------------------ISDLTAD--LYLMLDNAKKAFPT-------SHRTHK 430
            |..|:.|...|                  .||...|  .|:.|:.:.|...|       |.:..:
Mouse   259 HNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRRNTGSPDRKPSKKPKR 323

  Fly   431 DALKMLKLMNAKL-----VEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNS- 489
            |:..:...:|.||     :|:|| .|..|..::::.        |..||:...|..:|.|.:|: 
Mouse   324 DSSSLSSPLNPKLWCHVHLEKSL-NGPPLKVKNSKN--------SKSPEEHLEGVMKIMSPNNNK 379

  Fly   490 -NASHTPNNSNSPKSNRIAINAAIKKK-----ILSIQKYLVDYSLGNRRPIEMFMEKP------- 541
             ::.|.|....:.|......:..:|.|     ||:.||     |.||.:.....::.|       
Mouse   380 LHSFHIPKKGPAAKKPGKHSDKPLKAKGRGKGILNGQK-----STGNSKSPSKCVKTPKTKMKQM 439

  Fly   542 ----------------------------PRKIYPDYYDIIQNPIDMNTI----EHNIRTDRYAAV 574
                                        |.|..|        |..::.|    |:..:.|:.:|:
Mouse   440 TLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLP--------PAALHLIAYYKENKDKEDKKSAL 496

  Fly   575 EDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTA 639
            ..|:|....:.|     ||:.:.:.|:.    |||.:|..|   |.|.||   :::.:..:.:..
Mouse   497 SCVISKTARLLS-----NEDRARLPEEL----RALVQKRYE---LLEHKK---RWASMSEEQRKE 546

  Fly   640 VITERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDY---------YDIIREPIDMDRIAQ 695
            .:.::..:..|.::|..:.:.:|::   ..:|..:..:.|.         :.::..|        
Mouse   547 YLKKKRQELKERLREKAKERREREM---LERLEKQKRFEDQELGGRNLPAFRLVDTP-------- 600

  Fly   696 KLKQGAYDTLDDLAADFLLMLENACKYNE---PDSQIYKDALVLQQLTLQLKQQLRTERDSLPDV 757
               :|..:|   |..|..|::|....|:.   ||:|....|       :.|.:.|..::...   
Mouse   601 ---EGLPNT---LFGDVALVVEFLSCYSGLLLPDAQYPITA-------VSLMEALSADKGGF--- 649

  Fly   758 PLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVK-RRLDKGAYKR 821
             |.:..:.:.|..|:.  |||        :||  :|.|:  |.|:..|.|.|.. ..|.:...:|
Mouse   650 -LYLNRVLVILLQTLL--QDE--------IAE--DYGEL--GMKLSEIPLTLHSVSELVRLCLRR 699

  Fly   822 LDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRD-----------------ELCKDTL 869
            .|| |||    .|.:......||..|:|: |:|..|:.|.:                 .||...|
Mouse   700 CDV-QED----SEGSETDDNKDSTPFEDN-EVQDEFLEKLETSEFFELTSEEKLRILTALCHRIL 758

  Fly   870 SSSALNFSLE-RLMADVELC-----------------RQQKMQQEEQDQEQDKEKDEFNAA--KG 914
            .:.::...:| |.....||.                 :|::.:.|.:::|..||::.....  |.
Mouse   759 MTYSVQDHMETRQQVSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENVLGKVDRKK 823

  Fly   915 ESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLE 979
            |.:.|.|||....|.:...:...::.|                |||.   |..|.....|:..||
Mouse   824 EIVKIEQQVEVEADDMISAVKSRRLLS----------------MQAK---RKREIQERETKVRLE 869

  Fly   980 KE---------------VFKSSLSQT--------ISMDK-----------VQGMC----YVMNIK 1006
            :|               .|:..:::.        |..|:           |.|:.    :|.|..
Mouse   870 REAEEERMRKHKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSI 934

  Fly  1007 DY----IKMRPENLPEKDVYVCESRYNI---------QGRWFKKLKSWPPVREGSSVKFVPREQP 1058
            ||    .:....|||:.|......:.|:         .|...:.:::..| ::|.::.|:...|.
Mouse   935 DYRFKHHRKDHSNLPDDDYCPRSKKANLGKNASVNAHHGPALEAVETTVP-KQGQNLWFLCDSQK 998

  Fly  1059 LELKRVMSV----------FKERLEKHKGELEELKLQETLVEKEKPNV---SCDPPPNAEVGSTY 1110
             ||..::|.          .||||||...|     :..::....|||:   |||  .|.|:    
Mouse   999 -ELDELLSCLHPQGIRESQLKERLEKRYQE-----ITHSIYLARKPNLGLKSCD--GNQEL---- 1051

  Fly  1111 YQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYR 1175
               .|.:.|      |.:.|||:.            ::.|..|.:|.             .:|..
Mouse  1052 ---LNFLRS------DLIEVATRL------------QKGGLGYMEGT-------------SEFEA 1082

  Fly  1176 QELLLSTVEEVSPVVGIVGRCAVLEYSEFI----------SSRPTEISESDVYICESVYDELKKA 1230
            :.:.|..:::       .|.|.:...:..|          ..:..::...|....|.|.:|.|..
Mouse  1083 RVISLEKLKD-------FGECVIALQASVIKKFLQGFMAPKQKKRKLQSEDSTKSEEVDEEKKMV 1140

  Fly  1231 LRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLEDSMDGDTPSLSSDIAAMS 1295
            ....|...:.|              :||.|:.::.|......||||:       ..:..|::|.:
Mouse  1141 EEAKVASALEK--------------WKTAIREAQTFSRMHVLLGMLD-------ACIKWDMSAEN 1184

  Fly  1296 SPAPSVNSTPLTSKVKAAKSAKK-----CLTG--YILYSSEVRKSICQSNPDA-------TFGDI 1346
            :............|:.......|     ||..  |.:...|.:...||. |.|       .:.:.
Mouse  1185 ARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQP-PTARRNSRGRNYTEE 1248

  Fly  1347 SRMVGTEWKNLPSSVKQSWEDRASRQNEETAALR------------------------------- 1380
            |...|:|........::..|:....::.|.|.||                               
Mouse  1249 STSEGSEGDESGEEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKQSVIPAARPGRPPGKKSHPAR 1313

  Fly  1381 -------RELDD-------VQNSASPSSQVSQDVFGQVLTFECQW--------DKCDFQFEELSD 1423
                   .|:||       :....|...|..:|:..:::.:...|        |:.    |:..|
Mouse  1314 RSRPKDDPEVDDLVLQTKRISRRQSLELQKCEDILHKLVKYRFSWPFREPVTRDEA----EDYYD 1374

  Fly  1424 CTEHCMSDSTGHIQRHPQAGVETEYVCLWRNCPRVKKSVQAFPNVLRLIKHVREVHLSKCGKTIS 1488
            ..||.|...|  ||.....|   .|           :|||.|...::.:....|::..:....:|
Mouse  1375 VIEHPMDFQT--IQNKCSCG---NY-----------RSVQEFLTDMKQVFANAELYNCRGSHVLS 1423

  Fly  1489 AADRSKN-FVPRRQKH 1503
            ..::::. .:...|||
Mouse  1424 CMEKTEQCLLALLQKH 1439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 9/36 (25%)
Bromo_polybromo_II 191..294 CDD:99948 14/103 (14%)
Bromo_polybromo_III 335..443 CDD:99951 28/137 (20%)
Bromo_polybromo_IV 512..613 CDD:99949 27/144 (19%)
Bromo_polybromo_V 641..733 CDD:99946 16/103 (16%)
Bromo_polybromo_VI 758..867 CDD:99956 33/126 (26%)
BAH_polybromo 921..1040 CDD:240068 29/169 (17%)
BAH_polybromo 1120..1234 CDD:240068 17/123 (14%)
HMG-box 1320..1375 CDD:238037 11/63 (17%)
Baz1bNP_035844.2 WAC_Acf1_DNA_bd 21..120 CDD:287503 30/170 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..212 11/66 (17%)
C motif 207..213 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..333 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 376..433 13/61 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..472 2/23 (9%)
DDT 605..669 CDD:214726 18/87 (21%)
WHIM1 725..770 CDD:292246 7/44 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 789..813 4/23 (17%)
WHIM2 900..928 CDD:292247 4/27 (15%)
WHIM3 991..1029 CDD:292248 12/43 (28%)
PHD_BAZ1B 1186..1231 CDD:277098 6/44 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1231..1324 13/93 (14%)
Bromo_WSTF_like 1340..1436 CDD:99937 20/115 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1451..1479
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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