DRSC/TRiP Functional Genomics Resources

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Protein Alignment polybromo and BPTF

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:XP_005257207.1 Gene:BPTF / 2186 HGNCID:3581 Length:3158 Species:Homo sapiens


Alignment Length:1925 Identity:328/1925 - (17%)
Similarity:589/1925 - (30%) Gaps:644/1925 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SRKRRASSISSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRRLDPTELCQQLYDSIRNIKKEDG 67
            |.||:.|....:...:|    ||  |:..|:.:.......:..:|.:::.::....::.:...|.
Human  1075 SDKRKCSRSPKKIKIEP----DS--EKDEVKGSDAAKGADQNEMDISKITEKKDQDVKELLDSDS 1133

  Fly    68 SMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELLIGNAKAFYIPG 132
            ...|         ::||            ::|...:||:|:.:..:                   
Human  1134 DKPC---------KEEP------------MEVDDDMKTESHVNCQE------------------- 1158

  Fly   133 SSEHQDAVSLWQHIH-----SQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPG----GDGAT 188
             |...|.|::.:..|     .::.:..:.:||.|...:...:..:.|......|.|    |..:|
Human  1159 -SSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTST 1222

  Fly   189 DDEYN------------------------------QYEELF-------ASVMTATDPVGDRLMHR 216
            :...|                              |.|:|.       :||:..:||     .|.
Human  1223 NSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSSVLRMSDP-----SHT 1282

  Fly   217 MFQLLPSKKIYPDY-----------YDVIEHPIDLRL---------------------------- 242
            ..:|.|..::..|.           .:.||:.|:.::                            
Human  1283 TNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPSKSKTKGNDFFIDDSKLA 1347

  Fly   243 ----IATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGK 303
                |.|.|..|....:.|....::..:|:|...:.|.|...:||..|     .|.::.|   ||
Human  1348 SADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTNDRDATPL-----SRAMDFE---GK 1404

  Fly   304 LAKRVKSLSSAAIAALKEEV---DSSDDE---ETSKKGEGPMWALFDHLYNAPGTSEHPGVTGPP 362
            |.  ..|.|::.:....:.|   |||:::   :.|.:.....:...:.........:...|:|..
Human  1405 LG--CDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFRTREQDVEVLEPLKCELVSGES 1467

  Fly   363 LGNSLWKLPVR------RFHPEYFELIKRPISMSQIHTKL---------------KKGDYANISD 406
            .||...:|||:      :...:..:|.:||::......||               |||...:...
Human  1468 TGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQIKLKNTTDKKNNENRESEKKGQRTSTFQ 1532

  Fly   407 LTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVST 471
            :...     ||..|.:     ...:.||  ::..:::|..::|...:..::...|.|.:..||  
Human  1533 INGK-----DNKPKIY-----LKGECLK--EISESRVVSGNVEPKVNNINKIIPENDIKSLTV-- 1583

  Fly   472 QPEKRKPGRPRINS----------NSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDY 526
               |....||.||.          ||:...||..::|::..:.|.::.                 
Human  1584 ---KESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAEGNYRDSLE----------------- 1628

  Fly   527 SLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDV---VSDYRLMFSNC 588
            :|.:.:..:......|....|:...:.|                   |||:   .|:.:.:.|:.
Human  1629 TLPSTKESDSTQTTTPSASCPESNSVNQ-------------------VEDMEIETSEVKKVTSSP 1674

  Fly   589 RQYNEEG--SNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQFYET 651
            ....||.  ||.:.|.|.|....||.:       .|:..::........:.:.|.||.     :|
Human  1675 ITSEEESNLSNDFIDENGLPINKNENV-------NGESKRKTVITEVTTMTSTVATES-----KT 1727

  Fly   652 VKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLML 716
            |.:.:  ||.:|..:..|:..:||      .:......:.:::.....|:.|             
Human  1728 VIKVE--KGDKQTVVSSTENCAKS------TVTTTTTTVTKLSTPSTGGSVD------------- 1771

  Fly   717 ENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGR 781
                                   .:.:|:|.:|                 .:.||:.:.....|.
Human  1772 -----------------------IISVKEQSKT-----------------VVTTTVTDSLTTTGG 1796

  Fly   782 CYSDSLAELPEYD--------EIGEGPKVR-GISLDLVKRRLDKGAYKRLDVYQEDIFACLERAR 837
            ....|:....||.        :.....|.| |.:|...::.:.|.:.|.:.|...|      ..:
Human  1797 TLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPND------DLK 1855

  Fly   838 KLSRTDS---------------DIFQDSIELQTYFIRKRDELCKDTLSSSA-LNFSLERLMADVE 886
            ||:|...               ||:.......|:.|..|..|  .|:.|.| ::..|..|.|.:.
Human  1856 KLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRL--QTVKSLAGVSLMLRLLWASLR 1918

  Fly   887 -------------LCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENK 938
                         ..|.:..:.|....|..|.:|                  .|.|        .
Human  1919 WDDMAAKAPPGGGTTRTETSETEITTTEIIKRRD------------------VGPY--------G 1957

  Fly   939 IPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVM 1003
            |.|..||.::        :....:...|.|| ....||.|.....:..                 
Human  1958 IRSEYCIRKI--------ICPIGVPETPKET-PTPQRKGLRSSALRPK----------------- 1996

  Fly  1004 NIKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVF 1068
                    |||...:....:.|:       |.                   .|:.|||..:.: |
Human  1997 --------RPETPKQTGPVIIET-------WV-------------------AEEELELWEIRA-F 2026

  Fly  1069 KERLEKHKGELEELKLQETLVEKEKPNV--SCDPPPNAEVGSTYYQQYNTI---CSGAIKTGDFV 1128
            .||:||.|.:..|.:.::.| |::||.|  :....|.:...||.......:   .||::.||..:
Human  2027 AERVEKEKAQAVEQQAKKRL-EQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSVTTGTKM 2090

  Fly  1129 YVATQTGKQSVAQVQQ---------IWEQNGKSYFKGPWLLPPSETTPGLGKQFY---------- 1174
            .:.|:.|..:....||         .|.:.|:|..........:.|....|:.|.          
Human  2091 VLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSATSTAATSATTIASTGQTFQITGNPVTMAG 2155

  Fly  1175 ----------RQELLL--------STVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICE 1221
                      ..:::.        ..|:....|:||:..........|.|.:|...:.:      
Human  2156 KVITKLPLPANSKIVAVNVPATQGGVVQVQQKVLGIIPSSTGTSQQTFTSFQPRTATVT------ 2214

  Fly  1222 SVYDELKKALRKLVTGNMRKFQHSPSVTEDEI----FYFKTPIKPSKDFKNELNELGMLEDSMDG 1282
                     :|...:|:.....:|..:|..:|    ...:||::.|...|..:....|::   .|
Human  2215 ---------IRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLGKAIIRTPVMVQ---PG 2267

  Fly  1283 DTPSLSSDI-------AAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPD 1340
            ....:.:.|       .|:|:| .:|:|||....:.:|.|     |..|..|:.......|....
Human  2268 APQQVMTQIIRGQPVSTAVSAP-NTVSSTPGQKSLTSATS-----TSNIQSSASQPPRPQQGQVK 2326

  Fly  1341 ATFGDISRMVGTEWKNLPSSVKQSWEDRASRQ----NEETAALRRELDDVQNSASPSSQVSQDVF 1401
            .|...::::......|...:|....:.:.:.|    .:....|......:..:|.|:..|.:.:|
Human  2327 LTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLPGPGQQLMQAAMPNGTVQRFLF 2391

  Fly  1402 GQVLTF-------------------ECQWDKCDFQFEELSDCT-EHCMSDSTGHIQRHPQAGVET 1446
            ..:.|.                   |.:..|...|.:...|.| ....|.|.|..:..||....:
Human  2392 TPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPS 2456

  Fly  1447 EYVCLWRNCPRVKKSVQAFPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVP 1511
            .     :..|:.:....|.|.|                              :.|...|..|||.
Human  2457 A-----QPQPQTQPQSPAQPEV------------------------------QTQPEVQTQTTVS 2486

  Fly  1512 I-PPSLAQSPRAPSNLEAVQLQQQQHPQQNMH--------------------------QLQQQQT 1549
            . .||.||...|.|:...|..|.|  ||.|:.                          |..|.||
Human  2487 SHVPSEAQPTHAQSSKPQVAAQSQ--PQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQT 2549

  Fly  1550 IVLGPPPEPLFVTVPPRTTRVIHSEAYIK-------YIESLQTGSHLNVVTCNNNWRRALTHITP 1607
            ....|.|      :.|.|:..|.|:...:       ..::|.:|..||.||.::..|..|....|
Human  2550 TTSQPIP------IQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVSSPSRPQLQIQQP 2608

  Fly  1608 -AQVVAKTALPEKWIGPNLRDQGNVVQALCHLRNFMVDDI 1646
             .||:|.         |.|:.|   ||.|..:::.:|..|
Human  2609 QPQVIAV---------PQLQQQ---VQVLSQIQSQVVAQI 2636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 13/116 (11%)
Bromo_polybromo_II 191..294 CDD:99948 27/182 (15%)
Bromo_polybromo_III 335..443 CDD:99951 20/128 (16%)
Bromo_polybromo_IV 512..613 CDD:99949 18/105 (17%)
Bromo_polybromo_V 641..733 CDD:99946 12/91 (13%)
Bromo_polybromo_VI 758..867 CDD:99956 23/132 (17%)
BAH_polybromo 921..1040 CDD:240068 17/118 (14%)
BAH_polybromo 1120..1234 CDD:240068 21/150 (14%)
HMG-box 1320..1375 CDD:238037 8/58 (14%)
BPTFXP_005257207.1 DDT 241..297 CDD:280886
WHIM1 339..388 CDD:292246
PHD1_BPTF 392..434 CDD:277034
Med15 2217..>2598 CDD:255446 81/432 (19%)
TNG2 2742..2972 CDD:227367
PHD2_3_BPTF 2923..2969 CDD:277035
PHD2_3_BPTF 2981..3027 CDD:277035
Bromo_gcn5_like 3043..3143 CDD:99941
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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