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Protein Alignment polybromo and EP300

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_001420.2	Gene:	EP300 / 2033	HGNCID:	3373	Length:	2414	Species:	Homo sapiens

Alignment Length:	1301	Identity:	241/1301 - (18%)
Similarity:	411/1301 - (31%)	Gaps:	501/1301 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 VEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAI 508
            :.||..|...::..:.||..||:.| ..:.|:.:|      |.|.:.:|..|..|
Human   997 ISESKVEDCKMESTETEERSTELKT-EIKEEEDQP------STSATQSSPAPGQS---------- 1044

  Fly   509 NAAIKKKILSIQK------------YLVD-YSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMN 560
                ||||...::            |..| .||..|:|::     |.....|||:||:::|:|::
Human  1045 ----KKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVD-----PQLLGIPDYFDIVKSPMDLS 1100

  Fly   561 TIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKL---KEFPGLTEG 622
            ||:..:.|.:|......|.|..|||:|...||.:.|.:|:..:.|.....:::   .:..|...|
Human  1101 TIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCG 1165

  Fly   623 KK---SQQKYSKVGRKLKTAVITERLWQFYET-----VKEYQEPKGKRQLSL------------- 666
            :|   |.|.....|::|.| :..:..:..|:.     .|.:.|.:|: .:||
Human  1166 RKLEFSPQTLCCYGKQLCT-IPRDATYYSYQNRYHFCEKCFNEIQGE-SVSLGDDPSQPQTTINK 1228

  Fly   667 -IFTKLPSKSEYPD------------------YYDIIREPID------MDRIAQKLKQGAYDT-- 704
             .|:|..:.:..|:                  :::|| .|..      :.:.|:..|:..:..
Human  1229 EQFSKRKNDTLDPELFVECTECGRKMHQICVLHHEII-WPAGFVCDGCLKKSARTRKENKFSAKR 1292

  Fly   705 ---------LDDLAADFLLMLENACKYNEPDS-QIYKDALVLQQLTLQLKQQLRT----ERDSLP 755
                     |::...|||.      :.|.|:| ::....:.....|:::|..::.    ..:...
Human  1293 LPSTRLGTFLENRVNDFLR------RQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDSGEMAE 1351

  Fly   756 DVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAY- 819
            ..|...:.||      .:...|....|:..  ..:.||......|..|.:.:..    ||...:
Human  1352 SFPYRTKALF------AFEEIDGVDLCFFG--MHVQEYGSDCPPPNQRRVYISY----LDSVHFF 1404

  Fly   820 ----KRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNFSLER 880
                .|..||.|.:...||..:||..|...|:                .|.
Human  1405 RPKCLRTAVYHEILIGYLEYVKKLGYTTGHIW----------------ACP-------------- 1439

  Fly   881 LMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVY-VQMPENKIPSICC 944
                                          .::|:            ||:: ...|:.|||
Human  1440 ------------------------------PSEGD------------DYIFHCHPPDQKIP---- 1458

  Fly   945 IERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYVMNIKDYI 1009
                     ..|.:|        |.|    :|.|:|.|     |:.|          |.:.||..
Human  1459 ---------KPKRLQ--------EWY----KKMLDKAV-----SERI----------VHDYKDIF 1487

  Fly  1010 KMRPEN--LPEKDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERL 1072
            |...|:  ...|::...|..:            ||.|.| .|:|.:.:|:. |.||..:...|..
Human  1488 KQATEDRLTSAKELPYFEGDF------------WPNVLE-ESIKELEQEEE-ERKREENTSNEST 1538

  Fly  1073 EKHKGELEELKLQE-----------TLVEKEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGD 1126
            :..||:.:..|.:.           :...|:||.:     ||  |.:...|:
Human  1539 DVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGM-----PN--VSNDLSQK------------- 1583

  Fly  1127 FVYVATQTGKQSVAQVQQIWEQNGKSYFKGPWL--LPPSETTPGLGKQFYRQELLLSTVEEVSPV 1189
             :|...:..|:....::.|         .||..  |||                    :.:..|:
Human  1584 -LYATMEKHKEVFFVIRLI---------AGPAANSLPP--------------------IVDPDPL 1618

  Fly  1190 VG---IVGRCAVL-----EYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQ--- 1243
            :.   :.||.|.|     ::.||.|.|..:.|.    :|..|....:...|.:.|.|..|..
Human  1619 IPCDLMDGRDAFLTLARDKHLEFSSLRRAQWST----MCMLVELHTQSQDRFVYTCNECKHHVET 1679

  Fly  1244 --HSPSVTEDE---IFYFKTPIKPSKDFKNELNELGM-LEDSMDGDTPSLSSDIAAMSSPAPSVN 1302
              |. :|.||.   |..:.|     |:..:::.:||: |:|.      |.:...||..||..|
Human  1680 RWHC-TVCEDYDLCITCYNT-----KNHDHKMEKLGLGLDDE------SNNQQAAATQSPGDS-- 1730

  Fly  1303 STPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWED 1367
                     ...|.::|:.. ::::.:.|.:.|                    :|||..|.
Human  1731 ---------RRLSIQRCIQS-LVHACQCRNANC--------------------SLPSCQKM---- 1761

  Fly  1368 RASRQNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTF------ECQWDKCDFQF-------- 1418
              .|..:.|...:|:    .|...|       :..|::..      .||.:||...|
Human  1762 --KRVVQHTKGCKRK----TNGGCP-------ICKQLIALCCYHAKHCQENKCPVPFCLNIKQKL 1813

  Fly  1419 -------------------------------EELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLW 1452
                                           :.|...|....:..||.....||.
Human  1814 RQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQT---------- 1868

  Fly  1453 RNCPRVKKSVQAFPNVLRLIKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLA-------TTV 1510
               |:.....|..|                       .:....::||.|....::       .|.
Human  1869 ---PQPTSQPQPTP-----------------------PNSMPPYLPRTQAAGPVSQGKAAGQVTP 1907

  Fly  1511 PIPPSLAQSP---RAPSNLE-AVQLQQQQHPQQNMHQLQ-QQQTIVLGPPP----EPLFVTVPPR 1566
            |.||..||.|   ..|:.:| |:|:|:....|:.|..:| .|:.|....||    .|:.:..||.
Human  1908 PTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPM 1972

  Fly  1567 T 1567
            |
Human  1973 T 1973

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.