DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment polybromo and pbrm-1

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_001021008.1 Gene:pbrm-1 / 172504 WormBaseID:WBGene00007042 Length:1883 Species:Caenorhabditis elegans


Alignment Length:1958 Identity:565/1958 - (28%)
Similarity:894/1958 - (45%) Gaps:387/1958 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLSRKRRASSISSRQDEDPLQLDDSTPEQSPVQQTTTQSARKKRRLDPTELCQQLYD-------- 57
            |.::::||:      :.||         :..|..|:|.|.::|.|:...|..::.::        
 Worm     1 MSTKRKRAA------EPDP---------EKDVASTSTASKKRKGRMTIAEKEKREFEMAKGNYVM 50

  Fly    58 -SIRNIKKEDG-SMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLEL 120
             .||..:...| :.:.::|:|:|.||.||.||:.|..|||:..:|.|||...|...|....|..:
 Worm    51 AQIRKHRSSAGNNSVFESFLRLPPRRFEPEYYEQVKEPIDVTTIQHKLKIPEYLTYDQFNDDFMM 115

  Fly   121 LIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGL--AEEEPRARRMSRQVRRMTSSTEPG 183
            .|.|...:|...|.||:|.:.:.:...:...::.....|  ||:|.....:...|:   ...||.
 Worm   116 FIKNNLTYYKDESEEHKDMMKIQELFEAATAKVKSGEYLDDAEDEEGDEDVEETVQ---EEEEPE 177

  Fly   184 GDGAT-------DDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLR 241
            ..|.:       |.::....:|..:|:.|||..| ||:...|::|.|::.:|.||:.|..||||:
 Worm   178 ESGTSSRDSTPMDLDHFMLCDLLGAVLEATDNTG-RLLCPPFRVLQSREDFPLYYEKIAKPIDLK 241

  Fly   242 LIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELE------MG 300
            .||.......||::.|::.||..:.|||..|:..||.|:|||:.||.:..::...||      |.
 Worm   242 TIAQNGVNKKYSTMKELKDDLFLLFKNAQQFSGNGSDIFKDAEQLKTVVKEKIARLEEKGVHPMR 306

  Fly   301 KGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEHPGVTGPPLGN 365
            :.|..:.|.:|.:|.........||.:||||....| |||.|:..:.||....:. .||   |.:
 Worm   307 RAKATRLVDALLTAVAVNENFSEDSEEDEETETNSE-PMWKLYWTIRNAVHEKDR-NVT---LAD 366

  Fly   366 SLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRTHK 430
            :..:||.:..:|:|::.||.|:|:..|:.:||.|.| ::..|.|||..|..||......|...:.
 Worm   367 NFLELPSKESYPDYYDEIKNPVSIFMINKRLKNGKY-DLKSLVADLMQMYSNAFDYNLESSEVYI 430

  Fly   431 DA--LKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPGRPRIN---SNSNSN 490
            .|  ||.|.:...|.:..|.         |..:.:.....::....|..|.|.||.   .:::|.
 Worm   431 SAEKLKALTISTCKQLVPSF---------DVSQYEPAPAQLTPVKPKATPHRARIKIEMPDTDSE 486

  Fly   491 ASHTP---NNSNSPKSNR------------------IAINAA-IKKKILS------IQKYLVDYS 527
            .|.||   :...|||..|                  :..||| :|:|.:.      |..|.|..:
 Worm   487 DSRTPPPTHKRKSPKKPRENGSVPTPTFKGRKSTIPVDPNAAYMKQKAMMQGLWNVIHSYRVASN 551

  Fly   528 LGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYN 592
            .|: .|...|::.|..|.||:||.||||||||.||...|...:|..|:.:::|.|:||||.|.:|
 Worm   552 PGH-WPAGAFIQLPSAKQYPEYYQIIQNPIDMKTIRMRIDGHQYPQVDAMINDCRVMFSNARDFN 615

  Fly   593 EEGSNIYEDANILERAL--------NEKL---------------------------------KEF 616
            |..|.|:.||..||:|:        |..|                                 |.|
 Worm   616 EPRSMIHMDAIQLEKAVLRAYEGMRNTSLGSSIPSTPHSSSSNLMKAMKLKTPKSEVRGRGKKNF 680

  Fly   617 PGLTEGKKSQQKYSKVGRKLKTAVI-----TERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSE 676
            .|..:.:.::....:..|.::.|::     .:::|:.::::|:.:|....|.|::.|.:||||.|
 Worm   681 SGSDDEESARINIQQHQRSMEDAIMQLPIEEQKMWRLFKSMKDVREEGTNRPLAVNFMRLPSKEE 745

  Fly   677 YPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTL 741
            :|.|||:|::|:||.||..||:...|.||.|:.:||:|||.||||:||.||.|||:|:.||:..|
 Worm   746 FPAYYDVIKKPMDMMRIKHKLENRQYVTLLDVVSDFMLMLSNACKFNETDSDIYKEAVSLQKALL 810

  Fly   742 QLKQQLRTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGI- 805
            ::|::|.| .|..|.|.:.::.:|.::|.::::.:||||:||||.|.|..|.      .|..|: 
 Worm   811 EMKRELDT-GDDAPRVQVELRTIFTSIFASLFSKKDEEGKCYSDHLTEFTEV------LKANGVP 868

  Fly   806 ------SLDLVKRRLDKGAYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDEL 864
                  :||.:|..:||..|:|||..|:|.|...||||:||:..|.:::.:..||..||.:||..
 Worm   869 SSEWPFTLDQIKMNIDKCRYRRLDKLQKDFFDLFERARELSKAGSSMYEAACTLQKSFIVERDTR 933

  Fly   865 CKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKE---KDEFNAAKGESMTINQQVFSP 926
            |||.:.|:|.....:.:...:|..|..|.::|..::..:|.   |...:..:.|.:.|:...:..
 Worm   934 CKDLIHSNAYCVIEKDIDEAIEKERSLKAKEEHDEEGGNKPAMVKRHESEVEMEDIEIDGTKYVA 998

  Fly   927 GDYVYV-QMPENKIP-SICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQ 989
            ..|.|| :..|.|.| .|..|||.:.....||.:|.....||.||.|:.:|||:::|||.:....
 Worm   999 PCYAYVSRSDEKKTPLHIFRIERTFKDENGEKALQGHWVYRPEETLHLASRKFMKQEVFLTPFRD 1063

  Fly   990 TISMDKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVP 1054
            |:..::::|.|.|:::..|.........|:|||:||.:|:.:.::|.||::||...|...:::..
 Worm  1064 TVLAERLRGRCVVISLSTYTSKVITEYSEEDVYLCEYKYHGKPKYFAKLRTWPFTAEDEELEYTK 1128

  Fly  1055 REQPLELKRVMSVF-------KERL----EKHKGELEELKLQETL-VEKEKPNVSCDPPPNAEVG 1107
            |.:.:..||.::..       |:.:    |:.:.|.:..:|:.:| :|:.:...|.|    .|.|
 Worm  1129 RTKLMTPKRNLTAVDSDGNEGKDDVIVDGEEEEDEEDRARLEVSLDMERFELEASKD----EESG 1189

  Fly  1108 STYYQQYNTICSGAIKTGDFVYVA-------TQTGKQSVAQVQQIW-EQNGKSYFKGPWLLPPSE 1164
            .||:||..:      :||.|.::.       .......|.::.:|| |::|..:|.|.|...|||
 Worm  1190 KTYFQQIRS------ETGKFFWLGQCVLVFNNMKPLCDVMKINKIWREKDGSEWFSGCWFARPSE 1248

  Fly  1165 TTPGLGKQFYRQELL-LSTVEEVSPVVGIVGRCAVLEYSEFISSRPTEISESDVYICE------- 1221
            |....|:.|::.|:: :...:|...:..|...|.|:....:|..|.||:||.||::||       
 Worm  1249 TIHDEGRLFFKNEVIAVYRNDETRKLCEIQRVCDVMPAKLYIKQRQTEVSECDVFVCETMVNGSA 1313

  Fly  1222 ------------SVYDELK----------KALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSK 1264
                        |:.||..          ||:||     |:..:...|:..:|:.::|.|||..|
 Worm  1314 DTPDDCSLFGFQSIVDEFSDAQTMNLDYGKAMRK-----MKAHKLHVSIPNEEVLFYKQPIKMDK 1373

  Fly  1265 DFKNELNELGM-----LEDSMDGDT---PSLSSDI-----------AAMSSPAPSVNSTPLTSKV 1310
            :....|...|:     |::.||.||   .|:||.|           |.:.|...||::.|....:
 Worm  1374 ELSPLLKGEGVMPLDHLDEMMDDDTDGSESVSSSIHPKILKEGSPPATVQSQTSSVSTPPQHPSI 1438

  Fly  1311 KA-----AKSAKKCLTGYILYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSVKQSWEDRAS 1370
            .|     ...|.|..:||||:|:||||.|...||||.||::|::||.|||.|....|:.:|.|| 
 Worm  1439 SAEMPIMTPKAVKSKSGYILFSAEVRKRIMHENPDAGFGEVSKIVGIEWKKLSEEQKKHYEMRA- 1502

  Fly  1371 RQNEETAALRRELDDVQNSASPSSQVSQDVFGQVLTFECQWDKCDFQFEELSDCTEHCMSDSTGH 1435
                |..|:.:...|    |..:||....:.|||..::|:|..||.|::..|...||.:...|..
 Worm  1503 ----EVVAVEKAKQD----AIKASQAMTLLPGQVRIYQCKWAACDSQYDTESALLEHVIQHHTSQ 1559

  Fly  1436 IQRHPQAGVETEYVCLWRNCPRVKKSVQAFPNVLRLIKHVREVHLSKCGKTISAADRSKNF---V 1497
            |....    :.::||:|..|.|.:|..:.||::.||.:|::|.|:....|.|.:....|||   :
 Worm  1560 IIMDS----DQQFVCMWMTCLRNRKDGKPFPSLPRLHRHIKEKHMPTAAKNIYSNQLGKNFFKSI 1620

  Fly  1498 PRRQKHAQLATTVPIPPSLAQSPRAPSN---LEAVQLQQQQH-------------PQ-------- 1538
            | .|........|..|  ..|.|.||||   ....|.|||||             ||        
 Worm  1621 P-NQGDTPGCRIVSAP--YGQLPTAPSNGGIPPQQQHQQQQHHGNGMNGNMQQGAPQVINRHPVS 1682

  Fly  1539 QNMH--------------------------------------------------------QLQQQ 1547
            |.||                                                        |:.||
 Worm  1683 QQMHHQHPQHMQQHHDHHPHQQHYQQGGQPHPQMQMGPPQNGMFQQGSSSSQQYHQAPPQQMIQQ 1747

  Fly  1548 QTIVLGPPP-------EPLFVT---------------VPP---RTTRVIHSEAYIKYIESLQTGS 1587
            |....||||       :|:.||               .||   .:.||:|||||:||||||....
 Worm  1748 QHQQPGPPPQQQQPQMQPIVVTDVGRTVVRAVVPAFVAPPNQIHSRRVLHSEAYLKYIESLAQNR 1812

  Fly  1588 HLNVVTCNNNWRRAL-THITPAQVVAKTALPEKWI-----GPNLRDQGNVVQALCHLRNFMVDDI 1646
            ..:|    :.|.|.| ......|.......|..||     |..:..:.:|.:||..||    |::
 Worm  1813 QKSV----SRWERTLGATARNTQPAGNARAPSHWIRRIENGRPVAREEDVTKALWKLR----DEL 1869

  Fly  1647 LQIRRSCN 1654
            |  :.:|:
 Worm  1870 L--KSTCS 1875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 31/121 (26%)
Bromo_polybromo_II 191..294 CDD:99948 38/102 (37%)
Bromo_polybromo_III 335..443 CDD:99951 35/109 (32%)
Bromo_polybromo_IV 512..613 CDD:99949 44/114 (39%)
Bromo_polybromo_V 641..733 CDD:99946 43/96 (45%)
Bromo_polybromo_VI 758..867 CDD:99956 41/115 (36%)
BAH_polybromo 921..1040 CDD:240068 39/120 (33%)
BAH_polybromo 1120..1234 CDD:240068 38/151 (25%)
HMG-box 1320..1375 CDD:238037 27/54 (50%)
pbrm-1NP_001021008.1 Bromo_polybromo_I 40..153 CDD:99954 30/112 (27%)
Bromodomain 198..293 CDD:383021 38/95 (40%)
Bromo_polybromo_III 343..443 CDD:99951 34/104 (33%)
Bromo_polybromo_V 535..638 CDD:99946 41/103 (40%)
Bromo_polybromo_V 710..815 CDD:99946 48/104 (46%)
Bromo_polybromo_VI 822..936 CDD:99956 43/119 (36%)
BAH_polybromo 993..1114 CDD:240068 39/120 (33%)
BAH_polybromo 1201..1313 CDD:240068 31/111 (28%)
HMG-box 1451..1503 CDD:238037 28/56 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159200
Domainoid 1 1.000 102 1.000 Domainoid score I4332
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10044
Inparanoid 1 1.050 662 1.000 Inparanoid score I395
Isobase 1 0.950 - 0.959148 Normalized mean entropy S4369
OMA 1 1.010 - - QHG52483
OrthoDB 1 1.010 - - D168080at2759
OrthoFinder 1 1.000 - - FOG0002672
OrthoInspector 1 1.000 - - oto20237
orthoMCL 1 0.900 - - OOG6_103614
Panther 1 1.100 - - LDO PTHR16062
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R11130
SonicParanoid 1 1.000 - - X2912
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1615.890

Return to query results.
Submit another query.