DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and Crebbp

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_006521814.1	Gene:	Crebbp / 12914	MGIID:	1098280	Length:	2451	Species:	Mus musculus

Alignment Length:	1952	Identity:	345/1952 - (17%)
Similarity:	600/1952 - (30%)	Gaps:	746/1952 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TTTQSARKKRRLDPTELCQQLYDSIRNIKKEDGSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKV 99
            |...:|.|.||::         :.:...||.:|.|       .........||.::...|  .|:
Mouse   614 TPDPAALKDRRME---------NLVAYAKKVEGDM-------YESANSRDEYYHLLAEKI--YKI 660

  Fly   100 QQKLKTDSYDDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEP 164
            |::|:......|..     :.::||..|  :|.|......:       ...|.:...||     |
Mouse   661 QKELEEKRRSRLHK-----QGILGNQPA--LPASGAQPPVI-------PPAQSVRPPNG-----P 706

  Fly   165 RARRMSR-QVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYP 228
            ....::| ||.:..:|..|...|              :|.....|:|.|....|
Mouse   707 LPLPVNRMQVSQGMNSFNPMSLG--------------NVQLPQAPMGPRAASPM----------- 746

  Fly   229 DYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQR 293
                  .|         .:|||:.:|:..|.....:|.:...:.....:.|...|.:..:...|.
Mouse   747 ------NH---------SVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQN 796

  Fly   294 RIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDHL-YNAPGTS---- 353
            :.....|    |..|.|:.....||          :....:|:.|..||.:.| ..||..|
Mouse   797 QFPSSSG----AMSVNSVGMGQPAA----------QAGVSQGQVPGAALPNPLNMLAPQASQLPC 847

  Fly   354 ------------------------EH---PGVTGP----------PLGNSLWKLPVRRFHPEYFE 381
                                    :|   ||:|.|          |:.:.....|.....|...:
Mouse   848 PPVTQSPLHPTPPPASTAAGMPSLQHPTAPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQ 912

  Fly   382 L--------------------------IKRPISMSQ----IHTKLKKGDYANISDLTADLYLMLD 416
            .                          :..|.|..|    :||: ..|...:.:..:.|..:...
Mouse   913 TQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQ-PPGTPLSQAAASIDNRVPTP 976

  Fly   417 NAKKAFPTSHRTHKDALKMLKLM-------------------NAKLVEESLEEGSDLDDE-DAEE 461
            ::..:..||.:.....:.||::.                   .::::||.|:..|.:.:| |..|
Mouse   977 SSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRSEMMEEDLQGSSQVKEETDTTE 1041

  Fly   462 MDTEVFTV-STQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQK---- 521
            ..:|...| ..:||.:...:....::||..||    .|.||...|        |||...::
Mouse  1042 QKSEPMEVEEKKPEVKVEAKEEEENSSNDTAS----QSTSPSQPR--------KKIFKPEELRQA 1094

  Fly   522 --------YLVD-YSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDV 577
                    |..| .||..|:|::     |.....|||:||::||:|::||:..:.|.:|......
Mouse  1095 LMPTLEALYRQDPESLPFRQPVD-----PQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQY 1154

  Fly   578 VSDYRLMFSNCRQYNEEGSNIYED----ANILERALNEKLKEFPGLTEGKK---SQQKYSKVGRK 635
            |.|..|||:|...||.:.|.:|:.    |.:.|:.::..::.. |...|:|   |.|.....|::
Mouse  1155 VDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSL-GYCCGRKYEFSPQTLCCYGKQ 1218

  Fly   636 L-----------------KTAVITERLWQFYETVKEYQEPKGKR----------QLSLI---FTK 670
            |                 |..::.:| :.|.|  |.:.|.:|:.          |.::.   |.|
Mouse  1219 LCTIPRDAAYYSYQNSSPKYGLLADR-YHFCE--KCFTEIQGENVTLGDDPSQPQTTISKDQFEK 1280

  Fly   671 LPSKSEYPD------------------YYDII--------------REPIDMDRIAQKLKQGAY- 702
            ..:.:..|:                  :||||              ..|...::.:.|..|...
Mouse  1281 KKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRL 1345

  Fly   703 -DTLDDLAADFLLMLENACKYNEPDS-QIYKDALVLQQLTLQLKQQLRT----ERDSLPDVPLAV 761
             :.|:|....||.      :.|.|:: :::...:.....|:::|..:::    ..:.....|...
Mouse  1346 GNHLEDRVNKFLR------RQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRT 1404

  Fly   762 QELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGI------SLDLVKRRLDKGAYK 820
            :.||      .:...|....|:..  ..:.||......|..|.:      |:...:.|.     .
Mouse  1405 KALF------AFEEIDGVDVCFFG--MHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRC-----L 1456

  Fly   821 RLDVYQEDIFACLERARKL------------SRTDSDIFQ---------DSIELQTYFIRKRDEL 864
            |..||.|.:...||..:||            |..|..||.         ....||.::.:..|:.
Mouse  1457 RTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKA 1521

  Fly   865 CKDTLSSSALNFSLERLMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGESMTINQQV-FSPGD 928
                       |: ||::.|.                    ||.|..|..:.:|..::: :..||
Mouse  1522 -----------FA-ERIINDY--------------------KDIFKQANEDRLTSAKELPYFEGD 1554

  Fly   929 YVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISM 993
            :                   |.:...|.:                  |.||:|
Mouse  1555 F-------------------WPNVLEESI------------------KELEQE------------ 1570

  Fly   994 DKVQGMCYVMNIKDYIKMRPENLPEKDVYVCESRYNIQG--RWFKKLKSWPPVREGSSVKFVPRE 1056
                              ..|...|:.....|:....||  :..||..:....:..||:....::
Mouse  1571 ------------------EEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKK 1617

  Fly  1057 QPLELKRVMSVFKERL----EKHKGELEELKL--------QETLVEKEKPNVSCD---------- 1099
            :| .:..|.:...::|    ||||.....:.|        |..:|:.: |.:|||
Mouse  1618 KP-SMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPD-PLLSCDLMDGRDAFLT 1680

  Fly  1100 --PPPNAEVGSTYYQQYNTIC-------SGAIKTGDFVYVATQTGKQSVAQVQQIWE-------- 1147
              ...:.|..|....:::|:|       .|..:   |||    |..:....|:..|.
Mouse  1681 LARDKHWEFSSLRRSKWSTLCMLVELHTQGQDR---FVY----TCNECKHHVETRWHCTVCEDYD 1738

  Fly  1148 -----QNGKSYFKG--PWLL----------PPSETTPGLGKQFYRQELLLSTV------------ 1183
                 .|.||:...  .|.|          .|...:|...::...|..:.|.|
Mouse  1739 LCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSL 1803

  Fly  1184 ---EEVSPVVGIV--------GRCAVLEYSEFIS-----SRPTEISESDVYICESVYDELKK--- 1229
               :::..||...        |.|.|.:  :.|:     ::..:.::..|..|.::..:|::
Mouse  1804 PSCQKMKRVVQHTKGCKRKTNGGCPVCK--QLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQI 1866

  Fly  1230 ---------ALRKLVTGNMRKF--QHSPSVTE-------DEIFYFKTPIKPSKDFKNELNELGML 1276
                     ..|::.|.|.|..  |..||.|.       .:....:||..|::...:.:|
Mouse  1867 QHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVN----- 1926

  Fly  1277 EDSMDGDTPSLSSDIAAMSSPA--PSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNP 1339
                              .|||  |:|..|...:.|.|.|.           :::|......:.|
Mouse  1927 ------------------MSPAGFPNVARTQPPTIVSAGKP-----------TNQVPAPPPPAQP 1962

  Fly  1340 DATFGDISRMVGTEWKNLPSSVKQSWEDRASRQNEETAALRREL--DDVQNS--------ASPSS 1394
            .                 |::|:      |:||.|..|..::.|  .::.|.        .:|.|
Mouse  1963 P-----------------PAAVE------AARQIEREAQQQQHLYRANINNGMPPGRAGMGTPGS 2004

  Fly  1395 QVS---------QDVFGQVLTF--ECQWDKCDFQFEELSDCTEHCMSDSTGHIQRHPQAGVETEY 1448
            |::         ..|.|.|::.  ..||.:....                   |:.|..|:
Mouse  2005 QMTPVGLNVPRPNQVSGPVMSSMPPGQWQQAPIP-------------------QQQPMPGM---- 2046

  Fly  1449 VCLWRNCPRVKKSVQA--------FPNV--------------LRLIK-------HVREVHLSKCG 1484
                   ||...|:||        .|||              ||.:|       ..:.:::.|..
Mouse  2047 -------PRPVMSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSN 2104

  Fly  1485 KTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQQQQHPQQNMHQ---LQQ 1546
            ..:.||     |:.:|     .|..|...|.:...|       .:|.|....||..|||   ||.
Mouse  2105 PQLMAA-----FIKQR-----TAKYVANQPGMQPQP-------GLQSQPGMQPQPGMHQQPSLQN 2152

  Fly  1547 QQTIVLG------PPPEPLFVTVPPRTTRVIHSEAYIKYIESLQTGSHLNVVTCNNNWRRALTHI 1605
            ...:..|      |||:|....:.|:                   |..||::...:|  ..:|::
Mouse  2153 LNAMQAGVPRPGVPPPQPAMGGLNPQ-------------------GQALNIMNPGHN--PNMTNM 2196

  Fly  1606 TP 1607
            .|
Mouse  2197 NP 2198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	17/111 (15%)
		Bromo_polybromo_II	191..294	CDD:99948	15/102 (15%)
		Bromo_polybromo_III	335..443	CDD:99951	27/198 (14%)
		Bromo_polybromo_IV	512..613	CDD:99949	34/117 (29%)
		Bromo_polybromo_V	641..733	CDD:99946	23/139 (17%)
		Bromo_polybromo_VI	758..867	CDD:99956	26/135 (19%)
		BAH_polybromo	921..1040	CDD:240068	15/121 (12%)
		BAH_polybromo	1120..1234	CDD:240068	27/178 (15%)
		HMG-box	1320..1375	CDD:238037	7/54 (13%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:366931
		KIX	586..666	CDD:366953	15/69 (22%)
		PHA03247	<687..1037	CDD:223021	63/416 (15%)
		COG5076	942..>1194	CDD:227408	64/269 (24%)
		Bromo_cbp_like	1088..1195	CDD:99927	31/111 (28%)
		RING_CBP-p300	1207..1289	CDD:276805	14/84 (17%)
		PHD_CBP_p300	1291..1322	CDD:277032	4/30 (13%)
		HAT_KAT11	1353..>1564	CDD:369758	45/280 (16%)
		ZZ_CBP	1716..1756	CDD:239077	7/43 (16%)
		ZnF_TAZ	1777..1855	CDD:214717	10/79 (13%)
		Med15	1971..>2422	CDD:312941	58/296 (20%)
		Creb_binding	2045..2125	CDD:370251	19/100 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900