DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and Baz2a

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_011241580.1	Gene:	Baz2a / 116848	MGIID:	2151152	Length:	1888	Species:	Mus musculus

Alignment Length:	1830	Identity:	317/1830 - (17%)
Similarity:	568/1830 - (31%)	Gaps:	662/1830 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DPTELCQQLYDSIRNIKKEDGSMLCDTFIRVPKRRQEP---SYYDVVVNPIDLLKVQQKLKTDSY 108
            ||:.|..||.|:  .|..||.....|:....     ||   |.|.  ::..:|:..:.||..:.
Mouse   278 DPSHLPDQLEDT--PILSEDSLEPFDSLAAA-----EPVSGSLYG--IDDAELMGAEDKLPLEG- 332

  Fly   109 DDLDDLMADLEL-LIGNAKAFYIPGSSEHQDAVSLWQHIHSQ---RQRIMEAN--GL-----AEE 162
               :.:::.|:. .:.||.||.:. :.:.|.:.|::....|.   .:.:::.|  ||     :|:
Mouse   333 ---NPVISALDCPALSNANAFSLL-ADDSQTSASIFVSPTSPPVLGESVLQDNSFGLNSCSDSEQ 393

  Fly   163 EPRARRMSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIY 227
            |....:.|...|.:   |||..|....      .:|..:|.....|..        .|..|.:|.
Mouse   394 EEIETQSSNFQRPL---TEPAPDQPPS------TQLHPAVSPTASPAA--------SLTASAEIS 441

  Fly   228 PDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQ 292
            |....|...|:...:.   :.::..||.| :....|:.:....:.:..||.....|.:.:.:...
Mouse   442 PAVSPVASSPVPPEVF---VAVSPASSPA-LPAISLEASMTTPVTSPQGSPEPSPAAAFQTVSPA 502

  Fly   293 RRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEET-----SKKGEGPMWALFDHLYNAPGT 352
            |               |::|||..|       .:|.|||     :..|.|      |.|.....|
Mouse   503 R---------------KNVSSAPKA-------RADREETTGGAVAVSGSG------DVLKRRIAT 539

  Fly   353 SEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDN 417
            .|...:   ||.:. |:..||                      :|||.:....:..  .|.....
Mouse   540 PEEVRL---PLQHG-WRREVR----------------------IKKGSHRWQGETW--YYGPCGK 576

  Fly   418 AKKAFPTSHRTHKDALKMLKLMNAKLVEESLEE----------GSDLDDED-----------AEE 461
            ..|.||          :::|.::..:|.....|          |...::.|           |||
Mouse   577 RMKQFP----------EVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEE 631

  Fly   462 MDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDY 526
            :.:.:..::     .|.||||.|..:        .|...||..|
Mouse   632 IPSRIQAIT-----GKRGRPRNNEKA--------KNKEVPKVKR--------------------- 662

  Fly   527 SLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQY 591
              |..|        ||:...|:    :.|..| |.:...:.|....:.:|...    |..|.::.
Mouse   663 --GRGR--------PPKIKMPE----LLNKTD-NRLPKKLETQEILSEDDKAK----MTKNKKKM 708

  Fly   592 NEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQ 656
            .::.........:..:|.|::.::...|.: |.:::|......|:||.         .|.:||
Mouse   709 RQKVQRGESQTPVQGQARNKRKQDTKSLKQ-KDTKKKLKAEKEKMKTK---------QEKLKE-- 761

  Fly   657 EPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACK 721
              |.||:          |.|               ::..|.|:|. .......||..|..:...:
Mouse   762 --KVKRE----------KKE---------------KVKAKGKEGP-RARPSCRADKTLATQKRLE 798

  Fly   722 YNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPD---VPLAVQELFLTLFTTIYNHQDEEGRCY 783
            ..:      :...:|:::....:....::...|||   :|      .|||          ..|.:
Mouse   799 EQQ------RQQAILEEMKKPTEDMCLSDHQPLPDFTRIP------GLTL----------SSRAF 841

  Fly   784 SDSLA------------------ELPEYDEIGEGPKVRGISLDLVKR---RLDKGAY--KRLDVY 825
            ||.|.                  ::|....:.||...:|.|||.|:.   ||.|.|.  ..|..|
Mouse   842 SDCLTIVEFLHSFGKVLGFDLTKDVPSLGVLQEGLLCQGDSLDKVQDLLVRLLKAALHDPGLPPY 906

  Fly   826 QEDIFACLERARKLSRTDSDI----------------FQDSIELQTYFIRKRDE-------LCKD 867
            .:.:....|:..::..|..::                |.||:..|.:..:...:       |..:
Mouse   907 CQSLKILGEKMSEIPLTRDNVSEILRCFLMAYRVEPSFCDSLRTQPFQAQPPQQKAAILAFLVHE 971

  Fly   868 TLSSSALNFSLERLMADVELCRQQK---------------------------------------M 893
            ..||:.:...:::.:..|..||:.|                                       :
Mouse   972 LNSSTIIINEIDKTLESVSSCRKNKWIVEGRLRRLKTALAKRTGRPEVMMEGAEDGLGRRRSSRI 1036

  Fly   894 QQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYVYVQMPENKIPSICCIERLWTSPTNEKLM 958
            .:|....|:::|::...|..|.......::    |.....:||        :||     ..|||.
Mouse  1037 MEETSGIEEEEEEENTTAVHGRRGRKEGEI----DVAASSIPE--------LER-----HIEKLS 1084

  Fly   959 QASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISM--DKVQGMCYVMN---------------IK 1006
            :..:|             |.:|.:..|.:.:.:|:  |:.:...:|:.               .:
Mouse  1085 KRQLF-------------FRKKLLHSSQMLRAVSLGQDRYRRHYWVLPYLAGIFVEGSEGSTVTE 1136

  Fly  1007 DYIKMRPENLPEKDVYVCES-RYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKE 1070
            |.||...|:|.|.......| |.:::........|..|.|.        |.:|.:.|
Mouse  1137 DEIKQETESLMEVVTSTPSSARASVKRELTGSNASTSPARS--------RGRPRKPK-------- 1185

  Fly  1071 RLEKHKGELEELKLQETLVE--KEKPNVSCDPPPNAEV------------------GSTY----- 1110
                 .|.|:...||.|:.|  .|:......|.|..::                  ||.:
Mouse  1186 -----PGSLQPQHLQSTIRECDSEQAQTQVHPEPQPQLQAPTQPHLQPSSGFLEPEGSPFSLGQS 1245

  Fly  1111 ---------------YQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQQIWEQN--------GKS 1152
                           .|.:|::.|.::.|.|     :..||...|..|.:.|..        |.
Mouse  1246 QHDLSQSAFLSWLSQTQSHNSLLSSSVLTPD-----SSPGKLDSAPSQSLEEPEPDEAQSCPGP- 1304

  Fly  1153 YFKGPWL------------LPP-----SETTPGLGKQFYRQELLLSTVEEVSPVVGIVGRCAVLE 1200
              :|||.            .||     .:.||.|       :||.|:....:|  |....|:.::
Mouse  1305 --QGPWFNFSAQIPCDAAPTPPPAVSEDQPTPSL-------QLLASSKPMNTP--GAANPCSPVQ 1358

  Fly  1201 Y----------------SEFISSRPTEISE---------------SDVYICE------------- 1221
            .                ||.:|..||.:.:               ...|:.:
Mouse  1359 LSSTHLPGGTPKRLSGDSEEMSQSPTGLGQPKRRGRPPSKFFKQVEQHYLTQLTAQPIPPEMCSG 1423

  Fly  1222 -------SVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKPSKDFKNELNELGMLEDS 1279
                   ...|.|.|||..  .|...|..|. .:::.:.|..:..::|..|...|.|||..||:.
Mouse  1424 WWWIRDPETLDVLLKALHP--RGIREKALHK-HLSKHKDFLQEVCLQPLTDPIFEPNELPALEEG 1485

  Fly  1280 MDGDTP---SLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGYILYSSEVRKSICQSNPDA 1341
            :...:|   :..:|:|.:..      ...|..:|             :|...::|...|.: ||:
Mouse  1486 VMSWSPKEKTYETDLAVLQW------VEELEQRV-------------VLSDLQIRGWTCPT-PDS 1530

  Fly  1342 TFGDISRMVGTEWKNLPSSVKQ-SWEDRA------SRQNE---ETAALR---------------- 1380
            |..|:     |..::||.|.:. .|..|.      .|||.   :.|.:|
Mouse  1531 TREDL-----TYCEHLPDSPEDIPWRGRGREGTVPQRQNNNPLDLAVMRLAVLEQNVERRYLREP 1590

  Fly  1381 ----------RELDDVQNSA--SPSSQVSQDVFGQVLTFECQWDKCDFQFEELSDCTEHCMSDST 1433
                      :.|....|.|  ..|:::|.::..:|..:....::|       ....:.|:  ..
Mouse  1591 LWAAHEVVVEKALLSTPNGAPDGTSTEISYEITPRVRVWRQTLERC-------RSAAQVCL--CM 1646

  Fly  1434 GHIQRH--------------PQAGVETEYVCLWRNCPR------VKKSVQAFPN-----VLRLIK 1473
            |.::|.              .:.|...|::.|...|.|      .:..::|.|.     .:.|.:
Mouse  1647 GQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCAVCLSQ 1711

  Fly  1474 HVREVHLSKCGKTISAADRSKNF---VPR---RQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQ 1532
            .|.|.:..:.|.......|..:|   .|.   |::....:...|..|...:...:|.       :
Mouse  1712 QVEEEYTQRPGFPKRGQKRKSSFPLTFPEGDSRRRMLSRSRDSPAVPRYPEDGLSPP-------K 1769

  Fly  1533 QQQHPQQNMH 1542
            :::|..::.|
Mouse  1770 RRRHSMRSHH 1779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	26/119 (22%)
		Bromo_polybromo_II	191..294	CDD:99948	16/102 (16%)
		Bromo_polybromo_III	335..443	CDD:99951	19/107 (18%)
		Bromo_polybromo_IV	512..613	CDD:99949	14/100 (14%)
		Bromo_polybromo_V	641..733	CDD:99946	14/91 (15%)
		Bromo_polybromo_VI	758..867	CDD:99956	29/154 (19%)
		BAH_polybromo	921..1040	CDD:240068	23/136 (17%)
		BAH_polybromo	1120..1234	CDD:240068	33/189 (17%)
		HMG-box	1320..1375	CDD:238037	16/64 (25%)
Baz2a	XP_011241580.1	PHA03307	269..>517	CDD:223039	59/295 (20%)
		PRK07003	<408..>534	CDD:235906	33/171 (19%)
		HAT_MBD	542..614	CDD:238691	16/109 (15%)
		DDT	840..902	CDD:214726	15/61 (25%)
		WSD	1101..>1132	CDD:373967	3/30 (10%)
		Atrophin-1	<1151..>1421	CDD:367360	50/307 (16%)
		WSD	<1424..1458	CDD:373967	8/36 (22%)
		PHD_BAZ2A	1663..1709	CDD:277099	7/45 (16%)
		Bromo_BAZ2A_B_like	1781..1877	CDD:99935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900