DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment polybromo and Brdt

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_006534791.1	Gene:	Brdt / 114642	MGIID:	1891374	Length:	961	Species:	Mus musculus

Alignment Length:	1167	Identity:	218/1167 - (18%)
Similarity:	364/1167 - (31%)	Gaps:	452/1167 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 PNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQNPIDM 559
            |...|:.||.|:.......::::....:...:|...::|::....|     .||||.||:.|:|:
Mouse    16 PEYINTKKSGRLTNQLQFLQRVVLKALWKHGFSWPFQQPVDAVKLK-----LPDYYTIIKTPMDL 75

  Fly   560 NTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFP------- 617
            |||:..:....|....:.:.|:..|||||..||:.|.:|...|..||:...:||.:.|
Mouse    76 NTIKKRLENKYYEKASECIEDFNTMFSNCYLYNKTGDDIVVMAQALEKLFMQKLSQMPQEEQVVG 140

  Fly   618 --------------------------------------GL------------------------- 619
                                                  ||
Mouse   141 GKERIKKDIQQKIAVSSAKEQIPSKAAENVFKRQEIPSGLPDISLSPLNMAQEAPPICDSQSLVQ 205

  Fly   620 -TEGKK--------------------------------------------SQQKYSKVGRKLKTA 639
             |:|.|                                            |||::    :.|||.
Mouse   206 ITKGVKRRADTTTPTTSIAKASSESPPTLRETKPVNMPVKENTVKNVLPDSQQQH----KVLKTV 266

  Fly   640 VITERLWQFYETVKE------------YQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDR 692
            .:||:|....|.:||            :..|.....|.|           .:|||:::.|:|:..
Mouse   267 KVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGL-----------HNYYDVVKNPMDLGT 320

  Fly   693 IAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDV 757
            |..|:....|....:.|||..||..|..|||.||.::...|..||.:       .......:||.
Mouse   321 IKGKMDNQEYKDAYEFAADVRLMFMNCYKYNPPDHEVVAMARTLQDV-------FELHFAKIPDE 378

  Fly   758 PLAVQELFLTLFTTIYNHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYKRL 822
            |  ::.:.....||  |......|   :|.:|....|...|         |....|:     :.|
Mouse   379 P--IESMHACHLTT--NSAQALSR---ESSSEASSGDASSE---------DSEDERV-----QHL 422

  Fly   823 DVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNFSLERLMADVEL 887
            ...||.:.|..::.:.||:         :.|:.  ::|::|..|.......:|...|......:.
Mouse   423 AKLQEQLNAVHQQLQVLSQ---------VPLRK--LKKKNEKSKRAPKRKKVNNRDENPRKKPKQ 476

  Fly   888 CRQQK-------------MQQEEQDQEQDKEKDEFNAAKGESMTINQQVFSPGDYV--YVQMPEN 937
            .:|::             ::.||:|..:....||   .:..|:.||:   .|||.:  .|.:.::
Mouse   477 MKQKEKAKINQPKKKKPLLKSEEEDNAKPMNYDE---KRQLSLDINK---LPGDKLGRIVHIIQS 535

  Fly   938 KIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTISMDKVQGMCYV 1002
            :.||:          .|....:..|   ..||...:|.:.|||                    ||
Mouse   536 REPSL----------RNSNPDEIEI---DFETLKASTLRELEK--------------------YV 567

  Fly  1003 MNIKDYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSV 1067
            :..     :|..:|..:...|..|:..:..                       |:.|||:|.:..
Mouse   568 LAC-----LRKRSLKPQAKKVVRSKEELHS-----------------------EKKLELERRLLD 604

  Fly  1068 FKERLEKHKGELEELKLQETLVEKEKPNVSCDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVAT 1132
            ...:|...|.:.:    :...|||..|.....|||...         ..:.||:..|.......:
Mouse   605 VNNQLNCRKRQTK----RPAKVEKPPPPPPPPPPPPPP---------PELASGSRLTDSSSSSGS 656

  Fly  1133 QTGKQSVAQVQQIWEQNGKSYFKGPWLLPPSETTPGLGKQFYRQELLLSTVEEVSPVVGIVGRCA 1197
            .:|..|        ..:|.|         .|.::.|
Mouse   657 GSGSSS--------SSSGSS---------SSSSSSG----------------------------- 675

  Fly  1198 VLEYSEFISSRPTEISESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKP 1262
                   .:|..::.|.||                             .|.:|.|||...|.:|
Mouse   676 -------SASSSSDSSSSD-----------------------------SSDSEPEIFPKFTGVK- 703

  Fly  1263 SKDFKNEL---NELGMLEDSMDGDTPSLSSDIAAMSSPAPSVNSTPLTSKVKAAKSAKKCLTGYI 1324
                :|:|   ..:..::.|:        .||.:..:|....::.|..:..|.::....|.....
Mouse   704 ----QNDLPPKENIKQIQSSV--------QDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVTQH 756

  Fly  1325 LYSSEVRKSICQSNPDATF---GDISRMV--------------------------------GTEW 1354
            |.::|...|: |:.|.:.:   ||..|::                                ...|
Mouse   757 LQATENTASV-QTQPLSEYVLLGDCKRVLLGPPVVHTSAESLTVLEPECHAPAQKDIKIKNADSW 820

  Fly  1355 KNL-----PSSVKQSWED------RASRQNEETA----ALRRELDDVQNSASPS-SQVSQDVFGQ 1403
            |:|     .|||.:|.::      :|:.:.|..|    .:|:.|:  .|:..|. ||.:|...|.
Mouse   821 KSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQMRKHLE--HNAKDPKVSQENQREPGS 883

  Fly  1404 VLTFECQWDKC-DFQFEELSDCTEHCMSDSTGHIQRHPQAGVETEYVCLW----RNCPRVKK 1460
            .||.|....|. |...||  |.:|          |:.|....:...  ||    ||..|.|:
Mouse   884 GLTLESLSSKVQDKSLEE--DQSE----------QQPPSEAQDVSK--LWLLKDRNLAREKE 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948
		Bromo_polybromo_III	335..443	CDD:99951
		Bromo_polybromo_IV	512..613	CDD:99949	28/100 (28%)
		Bromo_polybromo_V	641..733	CDD:99946	28/103 (27%)
		Bromo_polybromo_VI	758..867	CDD:99956	20/108 (19%)
		BAH_polybromo	921..1040	CDD:240068	20/120 (17%)
		BAH_polybromo	1120..1234	CDD:240068	12/113 (11%)
		HMG-box	1320..1375	CDD:238037	16/100 (16%)
Brdt	XP_006534791.1	Bromo_Brdt_I_like	26..132	CDD:99929	31/110 (28%)
		Bromo_Brdt_II_like	271..372	CDD:99930	29/118 (25%)
		BET	505..567	CDD:374956	19/100 (19%)
		BRD4_CDT	919..961	CDD:374989	5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810