DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment polybromo and BAZ1A

DIOPT Version :9

Sequence 1:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster
Sequence 2:NP_038476.2 Gene:BAZ1A / 11177 HGNCID:960 Length:1556 Species:Homo sapiens


Alignment Length:708 Identity:130/708 - (18%)
Similarity:238/708 - (33%) Gaps:196/708 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLSRKRRASSISSRQDEDPLQLDDS-TPEQSPVQQTTTQSARKKRRLDPTELC--QQLYDSIRN- 61
            :|..|.|..:..:|..|:.....|. .|:..|    |....|.....||:::|  :||...:|: 
Human   922 LLQEKSRICAQLARFSEEKFHFSDKPQPDSKP----TYSRGRSSNAYDPSQMCAEKQLELRLRDF 982

  Fly    62 ---------------IKKED-----GSMLCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTD 106
                           ||..|     .::....:..:.:..:|......|...::.:::.::.|..
Human   983 LLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKTVNEDVEEMEIDEQTKVI 1047

  Fly   107 SYDDLDDLMADLELLIG-NAKAFYIPGSSEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARR-- 168
            ..|.|..:..:....:. ||.......|..|..|::|:|......:|.::|...|.:..|:.:  
Human  1048 VKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQIEQGIERRFLKAPLDASDSGRSYKTV 1112

  Fly   169 MSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDV 233
            :.|....:.||.             ...::|..:.|                             
Human  1113 LDRWRESLLSSA-------------SLSQVFLHLST----------------------------- 1135

  Fly   234 IEHPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELE 298
                :|..:|.:|..:||...:...:.|...|.  .|...:.|...|.....||.:         
Human  1136 ----LDRSVIWSKSILNARCKICRKKGDAENMV--LCDGCDRGHHTYCVRPKLKTV--------- 1185

  Fly   299 MGKG-------KLAKRVKSLSSAAIAALK-------------EEVDSSDDEETSKKGEGPMWALF 343
             .:|       :..:|.:.|||....:|:             :|||..::|..|::.|      :
Human  1186 -PEGDWFCPECRPKQRSRRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEE------Y 1243

  Fly   344 DHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLT 408
            :...:...:.|...|:.|..|....:|||:...       |...|.|....:.:.|.|.:     
Human  1244 EVEQDEDDSQEEEEVSLPKRGRPQVRLPVKTRG-------KLSSSFSSRGQQQEPGRYPS----- 1296

  Fly   409 ADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVE-ESLEEGSDLDDEDAEEMDTEVFTVSTQ 472
                    .::::.|.:..:.|....:.|:.:|...| :||...|.........:..:||.....
Human  1297 --------RSQQSTPKTTVSSKTGRSLRKINSAPPTETKSLRIASRSTRHSHGPLQADVFVELLS 1353

  Fly   473 PEKRKPGRPRINSNSNSNASHTPNNS-NSPKSNRIAINAAIKKKILSI-QKYLVDYSLGNRR--- 532
            |.:::.||        .:|::||.|| |.|....||..::.:.:.::| .|..:..|...||   
Human  1354 PRRKRRGR--------KSANNTPENSPNFPNFRVIATKSSEQSRSVNIASKLSLQESESKRRCRK 1410

  Fly   533 -------PIEM--------------------------------FMEKPPRKIYPDYYDIIQNPID 558
                   |:.:                                |::...:...|||||||:.||.
Human  1411 RQSPEPSPVTLGRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIA 1475

  Fly   559 MNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEF 616
            :|.|...:....|....:.:.|..||||||.:||..        |..|.....:|:.|
Human  1476 LNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPR--------NTSEAKAGTRLQAF 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 23/135 (17%)
Bromo_polybromo_II 191..294 CDD:99948 14/102 (14%)
Bromo_polybromo_III 335..443 CDD:99951 17/107 (16%)
Bromo_polybromo_IV 512..613 CDD:99949 30/143 (21%)
Bromo_polybromo_V 641..733 CDD:99946
Bromo_polybromo_VI 758..867 CDD:99956
BAH_polybromo 921..1040 CDD:240068
BAH_polybromo 1120..1234 CDD:240068
HMG-box 1320..1375 CDD:238037
BAZ1ANP_038476.2 Required for interaction with NCOR1. /evidence=ECO:0000269|PubMed:17519354 1..133
Required for association with the CHRAC1/POLE3 complex 1..128
WAC_Acf1_DNA_bd 23..122 CDD:313708
DDT 422..485 CDD:214726
WHIM1 590..635 CDD:317926
Neuromodulin_N <645..788 CDD:331332
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..754
Interaction with SMARCA5 667..933 3/10 (30%)
WSD 800..926 CDD:317927 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..877
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 941..966 5/28 (18%)
PHD_BAZ1A 1150..1195 CDD:277097 8/56 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1376 41/207 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1399..1431 4/31 (13%)
Bromo_Acf1_like 1423..1535 CDD:99936 26/111 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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