DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and BRD8

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	NP_631938.2	Gene:	BRD8 / 10902	HGNCID:	19874	Length:	1235	Species:	Homo sapiens

Alignment Length:	815	Identity:	161/815 - (19%)
Similarity:	287/815 - (35%)	Gaps:	257/815 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DEDPLQ--LDDSTPE--------QSPVQQTTTQSARKKRRLDPTEL-CQQLYDSIRNIKKEDGSM 69
            ||.||.  ..:::||        .:|::             ||.|. .|..::...::|:|.|::
Human   567 DETPLTNVKTEASPESMLSPSHGSNPIE-------------DPLEAETQHKFEMSDSLKEESGTI 618

  Fly    70 LCDTFIRVPKRRQEPSYYDVVVNPIDLLKVQQKLKTDSY-DDLDDLMADLELLIGNAKAFYIPGS 133
            ........|...:|.   |.|.....|.:.:::.:.:.| .::|:                .|..
Human   619 FGSQIKDAPGEDEEE---DGVSEAASLEEPKEEDQGEGYLSEMDN----------------EPPV 664

  Fly   134 SEHQDAVSLWQHIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDGATDDEYNQYEEL 198
            ||..|..|    ||:   ..::::.||:..|.:...|    :.:..:|       |.|..|.:::
Human   665 SESDDGFS----IHN---ATLQSHTLADSIPSSPASS----QFSVCSE-------DQEAIQAQKI 711

  Fly   199 F-ASVMTATDPVGDRLMHRMFQLLPSKKIYPDYYDVIEHPIDLRLIATKIQMNAYSSLAEMERDL 262
            : .::|.......:.....:|....:..|.|.|:.:::.|:||..|...|:.....|.||.:||:
Human   712 WKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDI 776

  Fly   263 LQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKR-VKSLSSAAIAA--LKEEVD 324
            :.|.:||.::|.....:|..|..::|..      ||..:..||.: :...|.:.|:|  |:.. |
Human   777 MLMFQNAVMYNSSDHDVYHMAVEMQRDV------LEQIQQFLATQLIMQTSESGISAKSLRGR-D 834

  Fly   325 SSDDEETSKKGEGPM--------------WALFDHLYNAPGTSEHPGVTGPPLGN------SLW- 368
            |:..::.|:|...||              |...|...:.|..||        |.|      |.|
Human   835 STRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSE--------LSNDCRSLFSSWD 891

  Fly   369 ---KLPVRRFH----PEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSH 426
               .|.|..:.    ||..||  ...|..:..::|..||..:.....|        |:||
Human   892 SSLDLDVGNWRETEDPEAEEL--EESSPEREPSELLVGDGGSEESQEA--------ARKA----- 941

  Fly   427 RTHKDALKMLKLMNAKLVE-------ESLE----------EGSDLDDEDAEE---MDTEVFTVST 471
             :|::.|..|..: |.|:|       ||.|          ||.::...:.|.   .:||..:...
Human   942 -SHQNLLHFLSEV-AYLMEPLCISSNESSEGCCPPSGTRQEGREIKASEGERELCRETEELSAKG 1004

  Fly   472 QP-EKRKP----GRPRINSNSNSNASHTPNNSNSPKSNRIAINAAIKKKILSIQKYLVDYSLGNR 531
            .| ...||    |:|.:                          |:....|.::|..|.:...|..
Human  1005 DPLVAEKPLGENGKPEV--------------------------ASAPSVICTVQGLLTESEEGEA 1043

  Fly   532 RP-----------IEMFMEKPPRKIYPDYYDIIQNPIDMNTIEH---NIRTDRYAAVEDVVSDYR 582
            :.           :....::||.....|.::|.:.|:......|   :..||  .:.:|.|.|:
Human  1044 QQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPLVDTLFSHATSSKLTD--LSQDDPVQDH- 1105

  Fly   583 LMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQ 647
            |:|.                                                  ||.:   .:|:
Human  1106 LLFK--------------------------------------------------KTLL---PVWK 1117

  Fly   648 FYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADF 712
            ..          ...:.|..|.|..|:.:.|.|.|:::.|:|:..:.:.|.:|...|:.....|.
Human  1118 MI----------ASHRFSSPFLKPVSERQAPGYKDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDL 1172

  Fly   713 LLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQL 747
            :||.:||..||:.|..:|..|:.::|..|:..|.|
Human  1173 MLMFQNAVMYNDSDHHVYHMAVEMRQEVLEQIQVL 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360	21/113 (19%)
		Bromo_polybromo_II	191..294	CDD:99948	24/103 (23%)
		Bromo_polybromo_III	335..443	CDD:99951	29/135 (21%)
		Bromo_polybromo_IV	512..613	CDD:99949	17/114 (15%)
		Bromo_polybromo_V	641..733	CDD:99946	22/91 (24%)
		Bromo_polybromo_VI	758..867	CDD:99956
		BAH_polybromo	921..1040	CDD:240068
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
BRD8	NP_631938.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..205
		termin_org_DnaJ	<302..>681	CDD:274808	28/152 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..597		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..672		11/69 (16%)
		Bromo_brd8_like	709..812	CDD:99939	24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..848		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..940		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..999		7/32 (22%)
		Bromo_brd8_like	1105..1208	CDD:99939	31/167 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900