DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment polybromo and brd2

DIOPT Version :9

Sequence 1:	NP_651288.1	Gene:	polybromo / 42954	FlyBaseID:	FBgn0039227	Length:	1654	Species:	Drosophila melanogaster
Sequence 2:	XP_012809277.2	Gene:	brd2 / 100038037	XenbaseID:	XB-GENE-481598	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	971	Identity:	183/971 - (18%)
Similarity:	323/971 - (33%)	Gaps:	359/971 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 TSSTEPGGDGATDDEYNQYEELFASVMTATDPVGDRLMHRMF-----QLLPSKKI-YPDYYDVIE 235
            ::|.:||      ...||.:.|...||.:       |....|     |.:.:.|: .|||:.:|:
Frog    67 SNSKKPG------RSTNQLQYLHKVVMKS-------LWKHQFSWPFRQPVDAVKLGLPDYHKIIK 118

  Fly   236 HPIDLRLIATKIQMNAYSSLAEMERDLLQMTKNACLFNEPGSQIYKDAKSLKRIFTQRRIELEMG 300
            .|:|:..|..:::.|.|.|..|..:|...|..|..::|:|...|...|:||:::|.|:..::...
Frog   119 QPMDMGTIKKRLENNYYWSALECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKMFLQKVAQMPQE 183

  Fly   301 KGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKKGEGPMWALFDHLYNAPGTSEH--PGVTGPPL 363
            :.::......:.:..|:                |..||...:         |:.|  |.|:
Frog   184 EQEIPNTASKIKNVKIS----------------KTSGPTGGV---------TTAHQVPAVS---- 219

  Fly   364 GNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKGDYANISDLTADLYLMLDNAKKAFPTSHRT 428
                                    |.|.::.                       :....||:
Frog   220 ------------------------SQSSLYP-----------------------SSPEVPTT--- 234

  Fly   429 HKDALKMLKLMNAKLVEESLEEGSDLDDEDAEEMDTEVFTVSTQPEKRKPG--RPRINSNSNSNA 491
                  ||.|.::.::...:     |....:.:....|...:|||..:|.|  |....:...:.|
Frog   235 ------MLSLAHSSIISNPV-----LKSMPSSQAVLSVLPGATQPVAKKKGVKRKADTTTPTTTA 288

  Fly   492 SHTPNNSNSPKSNRIAINAAIKK--KILSIQKYLVDYSLGNRRPIEMFMEKPPRKIYPDYYDIIQ 554
            ....:...||      :.|:..|  ||.:.::        :.|||     |||:|..||
Frog   289 IIATSGDLSP------LQASETKPAKIPARRE--------SGRPI-----KPPKKDLPD------ 328

  Fly   555 NPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERALNEKLKEFPGL 619
                                           |...|.:::|.            |:|:||...|:
Frog   329 -------------------------------SQQHQTSKKGK------------LSEQLKYCNGI 350

  Fly   620 TEG--KKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEPKGKRQLSLIFTKLPSKSEYPDYYD 682
            .:.  .|....|:               |.||       :|.....|.|           .||||
Frog   351 LKELLSKKHAAYA---------------WPFY-------KPVDVSALGL-----------HDYYD 382

  Fly   683 IIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQL 747
            ||:.|:|:..|.:|:....:....:.||...||..|..|||.||..:...|..||.:.     :.
Frog   383 IIKHPMDLSTIKKKMDNREFKDAQEFAAAVRLMFSNCYKYNPPDHDVVAMARKLQDVF-----EF 442

  Fly   748 RTERDSLPDVPLAVQELFLTLFTTIYNHQDEEGRCYSDSLAE-LPEYDEIGEGPKVRGISLDLVK 811
            |..:  :||.||.|...     :|.......:.:..|:|.:| ..|..:..|.      |.|..:
Frog   443 RYAK--MPDEPLVVNPP-----STSSQLPPSDSKSSSESSSESSSESSDDSES------SDDSEE 494

  Fly   812 RRLDKGAYKRLDVYQEDIFACLERARKLSRTDSDIFQDSIELQTYFIRKRDELCKDTLSSSALNF 876
            .|.:     ||...||.:.|..|:...||       |..|....   :||:
Frog   495 ERAN-----RLAELQEQLRAVHEQLAALS-------QGPISKPK---KKRE-------------- 530

  Fly   877 SLERLMADVELCRQQKMQQEEQDQEQDKEKDEFNAAKGE-----------------SMTINQQVF 924
                         :::.::::.|:::.|:.||:.::|.:                 |.|::..:.
Frog   531 -------------KKEKKKKKSDKKKRKDDDEWRSSKSKPSQAKKSSKKSGGGIATSSTVSPAIS 582

  Fly   925 SPGDYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQ 989
            ......:..:|  ..||:     |:.|...|:       .:| .||.       ||......:::
Frog   583 KSTKKTFKSVP--PAPSV-----LYDSEEEEE-------SKP-MTYD-------EKRQLSLDINK 625

  Fly   990 TISMDKVQGMCYVMNIK--------------DYIKMRPENLPEKDVYVCESRYNIQGRWFKKLKS 1040
             :..:|:..:.:::..:              |:..::|..|.|.:.||...
Frog   626 -LPGEKLGRVVHIIQSREPSLRDSNPEEIEIDFETLKPSTLRELERYVMSC-------------- 675

  Fly  1041 WPPVREGSSVKFVPREQPLE--LKRVMSVFKER--LEKHKGELEELKLQET---LVEKEKP 1094
               :|:.....:.|....|.  ||:.:...||.  ||| |.|||: :||:.   |...:||
Frog   676 ---LRKKPRKPYTPPNSVLSPALKKPVGKTKEEIALEK-KRELEK-RLQDVSGQLNSAKKP 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
polybromo	NP_651288.1	Bromodomain	46..158	CDD:295360
		Bromo_polybromo_II	191..294	CDD:99948	31/108 (29%)
		Bromo_polybromo_III	335..443	CDD:99951	13/109 (12%)
		Bromo_polybromo_IV	512..613	CDD:99949	17/102 (17%)
		Bromo_polybromo_V	641..733	CDD:99946	26/91 (29%)
		Bromo_polybromo_VI	758..867	CDD:99956	24/109 (22%)
		BAH_polybromo	921..1040	CDD:240068	18/132 (14%)
		BAH_polybromo	1120..1234	CDD:240068
		HMG-box	1320..1375	CDD:238037
brd2	XP_012809277.2	Bromo_Brdt_I_like	74..180	CDD:99929	31/112 (28%)
		Bromo_Brdt_II_like	343..444	CDD:99930	34/138 (25%)
		BET	610..674	CDD:407211	12/72 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910