DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ets96B and Etv4

DIOPT Version :9

Sequence 1:	NP_996290.1	Gene:	Ets96B / 42952	FlyBaseID:	FBgn0039225	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006247431.1	Gene:	Etv4 / 360635	RGDID:	1306524	Length:	533	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	169/579 - (29%)
Similarity:	224/579 - (38%)	Gaps:	164/579 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 IPPPPPPCCLTLGESSSSPNPIATAA-------------------LMNASTSGSSSAGGA----- 170
            :|||.     .:..|:..|.|:|..:                   ..:..:.|:.|.|.|
  Rat    24 LPPPS-----QVSASARGPGPVAGGSGRMERRMKGGYLDQRVPYTFCSQKSPGNGSLGEALMVPQ 83

  Fly   171 -------------SASLCNDLTR-ESSWYAHHHHHHHHHHHQLPDELVMYATPTPTPAIGKFGLD 221
                         |..|..||:. :.:|.|         ..|:||            :..:|..|
  Rat    84 GKLMDPGSLPPSDSEDLFQDLSHFQETWLA---------EAQVPD------------SDEQFVPD 127

  Fly   222 TSTEGYLNARYNVNVKGVRHDRTSSFFDIPAVTHPHNHPHPHPHPHPHPYCYRFPS-------SP 279
            ..:|   |..::.....::.:..|...| ||::.....|..:.|.....|...:.|       ||
  Rat   128 FHSE---NLAFHSPTTRIKKEPQSPRTD-PALSCSRKPPLSYHHGEQCLYSSAYDSPRQIAIKSP 188

  Fly   280 PAGILKKSDEEATSAAVYCSDV----SSGQHFPHHTKI-EHAD--------------------ST 319
            ..|...:|..:..|.|.....:    ||.|..|.|..: ||:.                    ..
  Rat   189 APGAPGQSPLQPFSRAEPQQSLLRASSSSQSHPGHGYLGEHSSVFQQPVDMCHAFTSPQGGGREP 253

  Fly   320 TTAAQQQQQQQEQQQQQQQQQQQQQHQQQLQQAAALHPHHHHSHHGHHGHQQAEQQALT-HLTPL 383
            ..|..|.|..:......||..:|:.|....:||               |...|.|..:: |..|
  Rat   254 LPAPYQHQLSEPCPPYPQQSFKQEYHDPLYEQA---------------GQPAASQGGVSGHRYP- 302

  Fly   384 HAASAFKFSHTAVISSSAVYATPSHYAHQQQTQSQSVYRDLSPTTLAAVSDADLKYDSGPYNAAI 448
            .|....|...|.....|.|....|.|.|              |...:|.|..|         ..:
  Rat   303 GAGVVIKQERTDFAYDSDVPGCASMYLH--------------PEGFSAPSSGD---------GVM 344

  Fly   449 SSTYPSALRP-----NVVDSTTSSDAELRLDQFYASNGISTSSNGQAISQRRGSLQLWQFLVALL 508
            ...|..:|||     .:|......|.:        ..|:.....|... ||||:|||||||||||
  Rat   345 GYGYEKSLRPFPDDVCIVPEKFEGDIK--------QEGVGAFREGPPY-QRRGALQLWQFLVALL 400

  Fly   509 DEPTTSASCIAWTGRGMEFKLIEPEEVARRWGLQKNRPAMNYDKLSRSLRYYYEKGIMQKVNGER 573
            |:| |:|..||||||||||||||||||||.||:||||||||||||||||||||||||||||.|||
  Rat   401 DDP-TNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGER 464

  Fly   574 YVYRFVCDPDALFNMAYGHLTTGSGKGDQHQLTLSLAKTPPTSGDSQTQSPRVAKSEYY 632
            |||:|||:|:|||::|:         .|.|:..|......|.|.:.......:.:|..|
  Rat   465 YVYKFVCEPEALFSLAF---------PDNHRPALKAEFDRPVSEEDTVPLSHLDESPAY 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets96B	NP_996290.1	ETS	497..583	CDD:197710	74/85 (87%)
Etv4	XP_006247431.1	ETS_PEA3_N	53..388	CDD:282476	74/407 (18%)
Etv4	XP_006247431.1	ETS	390..473	CDD:197710	74/83 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335585
Domainoid	1	1.000	149	1.000	Domainoid score	I4302
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001816
OrthoInspector	1	1.000	-	-		otm46015
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.800