Protein Alignment CG42331 and Duox1

DIOPT Version :10

• Sequence 1: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: NP_001092767.1
• Gene: Duox1 / 99439
• MGIID: 2139422
• Length: 1551
• Species: Mus musculus
• Alignment Length: 878
• Identity: 212/878 - (24%)
• Similarity: 341/878 - (38%)
• Gaps: 237/878 - (26%)

  Fly   187 DGTCNNKRRPRWGAAQMPFNRFLPPEYGDGVDTVRSSADGSTLSSSRFVSLLVHGAREGEAPL-- 249
            ||..||....|||:......|.:|..|.||   |........|.:.|.:|..|.....|:..|
Mouse    33 DGWYNNLMEHRWGSKGSRLQRLVPASYADG---VYQPLKEPYLPNPRHLSNRVMRGSAGQPSLRN 94

  Fly   250 -TLMIAQWGQMLDHDMTSTAQPRSINGSIPSCCGGKDFHPACF-PIKVPLDDPWLAPLKVR--CL 310
             |::...:|..:..|:.|.        ..|.|       ||.| .|.:|..||...|.|..  .|
Mouse    95 RTVLGVFFGYHVLSDLVSV--------ETPGC-------PAEFLNIYIPHGDPVFDPDKRGNVVL 144

  Fly   311 EFLRS--------APAQRRDCVLSWREQTNQVTSYIDASPIYSNSAKSSDNARVFRHG------- 360
            .|.||        :|:..||       |:||||.::|.|.||.:|...||..|.|..|
Mouse   145 PFQRSRWDRNTGQSPSNPRD-------QSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPD 202

  Fly   361 ----------LLVY-------GRGDPAEDVCQRGAIATKCIRSGDGRSGEQPGLLAMHHVWVGEH 408
                      ||::       |:|.|      ||..|     .|..|...:|.|.|:..:|...|
Mouse   203 PAFPSDSQSSLLMWMAPDPSTGQGGP------RGVYA-----FGAQRGNREPFLQALGLLWFRYH 256

  Fly   409 NRIAMELSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGREVVKLFDLELMPSGYYERY 473
            |..|.:|::.:|||.||:::|..|:.|.|.:|:|...|:||..|.:...:           |..|
Mouse   257 NLCARKLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPE-----------YPGY 310

  Fly   474 SSKVNPTVANAFAAAAFRFGHSLVQNS-YTRCDRHH--NVINNNVSL--------------HEEF 521
            ...::|:::..|..|:.:|..::|.:. |.|....|  .:.::|.|:              |.:.
Mouse   311 RPFLDPSISPEFVVASEQFLSTMVPSGVYMRNASCHFQGIPSHNSSVSGALRVCNSYWSREHPKL 375

  Fly   522 QRGDIGSAGSLHRLLRGLASQRALKRDEFITPELTNHLFQTPG-FPFG-LDLAAINIQRGRDHGI 584
            ||     |..:..||.|:|||.|.:.|..:..::.:.   .|| ..|. .|..|..:|||||.|:
Mouse   376 QR-----AEDVDALLLGMASQIAEREDHVVVEDMQDF---WPGPLKFSRTDYLASCLQRGRDLGL 432

  Fly   585 APYSAWRVPCGLSPILSWDDFANVVGPESAKRIG---HAYRSVHD-----IDLFVGGIAERPVVG 641
            ..|:..|...|||||..|.|    :.|..::..|   .|..::::     ::|..||:.|.   .
Mouse   433 PSYTKAREALGLSPISHWQD----INPALSRSNGTVLEATAALYNQDLSRLELLPGGLLES---H 490

  Fly   642 GLVGPTFACIIAQQFSNSRRGDRFWYEN--GGFESSFTPAQLHSLRRVSLAQVL--CRTVGGGTL 702
            |..||.|:.|:..||...|.|||:|:||  .|.   |:..::..:|..||..:|  ...|....|
Mouse   491 GDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGL---FSKEEIAEIRNTSLRDILVAVTNVDPSAL 552

  Fly   703 QPHIFI---------PAEFEDNERQTCG------------------VGSLS--PID--LSPW--- 733
            ||::|.         |::........|.                  :|:|.  |:.  ||.|
Mouse   553 QPNVFFWLAGDPCPQPSQLSAKGLPACAPLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVA 617

  Fly   734 -LEQDPFHNQQVPEQVFTIGQPELGSVQIIKEDKAGFSNRVKPIKP-QVEVSPSSLSGFHRPTNE 796
             |.:..|...|..::...:.:..:|.|:.::     :..|.:|.:| .|.:.|..:    |..:.
Mouse   618 RLRKRNFKRLQRQDRQSIMSEKLVGGVEALE-----WQGRNEPCRPVLVHLQPGQI----RVVDG 673

  Fly   797 NLTKVSDKLDLRRKTVTKKNNTNNRQQTTRKPVGGVNNKLDKSPK-----ITLNIKSVNVRRPEG 856
            .|| |...:.||.........::||         |....|.|.||     :..|::.
Mouse   674 RLT-VLRTIQLRPPQQVNLILSSNR---------GRRTLLLKIPKEYDLVLLFNMEE-------- 720

  Fly   857 SGLKRRVIINNVPVELRSSGGNATAEETEPGNLTDEDDEFHDDAGEVVDMEDIVEVRASKDDPSK 921
               :|:.::.||...|:.:|            |:.::.|..:        ::::....::.....
Mouse   721 ---ERQALVENVRGALKENG------------LSFQEWELRE--------QELMRAAVTRQQRGH 762

  Fly   922 LTKT----------DLNQNRNDSKTTETEQTEK 944
            |.:|          |:||  .|:.|...:.:.|
Mouse   763 LLETFFRHLFSQVLDINQ--ADAGTLPLDSSTK 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	164/588 (28%)
		LHP1	731..>871	CDD:227520	29/149 (19%)
Duox1	NP_001092767.1	dual_peroxidase_like	32..591	CDD:188652	167/622 (27%)
		EFh	820..881	CDD:238008
		EFh	857..915	CDD:238008
		PLN02292	1089..>1412	CDD:215165
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783