Protein Alignment CG42331 and EPX

DIOPT Version :10

• Sequence 1: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: NP_000493.1
• Gene: EPX / 8288
• HGNCID: 3423
• Length: 715
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 245/738 - (33%)
• Similarity: 350/738 - (47%)
• Gaps: 143/738 - (19%)

  Fly    68 LMDVA---LQQSVRQGLDAMTELYGRIQPEMLRNGQTLQDNHPAAMLSRFNAPTTDSERREMAAY 129
            |:|.|   .|:|::|               .||:|..    .|..:||.|..|        :||.
Human    46 LVDAAYNWTQKSIKQ---------------RLRSGSA----SPMDLLSYFKQP--------VAAT 83

  Fly   130 ATIAAAKAFRKNFQHI--DELARQSHTQRI------------SLRRTALEGLCPPRDPPP-CMPA 179
            .|:..|    .::.|:  ..|..:...||.            .||..:....|..||... |
Human    84 RTVVRA----ADYMHVALGLLEEKLQPQRSGPFNVTDVLTEPQLRLLSQASGCALRDQAERC--- 141

  Fly   180 SERYRTHDGTCNNKRRPRWGAAQMPFNRFLPPEYGDGVD-----TVRSSADGSTLSSSRFVS-LL 238
            |::|||..|.|||||||..||:.....|:||.||.||:.     |.....:|..|...|.|| .:
Human   142 SDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQI 206

  Fly   239 VHGARE------GEAPLTLMIAQWGQMLDHDMT-STAQPRSINGSIPSCCGGKDFH------PAC 290
            |....|      |.|   ||..||||.:|||:. |...|..:     :...|.|..      |.|
Human   207 VRFPNERLTSDRGRA---LMFMQWGQFIDHDLDFSPESPARV-----AFTAGVDCERTCAQLPPC 263

  Fly   291 FPIKVPLDDPWLAPLKVRCLEFLRSAPA--QRRDCVLSWREQTNQVTSYIDASPIYSNSAKSS-- 351
            ||||:|.:||.:...: .|:.|.||||:  |.::.|   |.|.|.:||::|||.:|.:....|
Human   264 FPIKIPPNDPRIKNQR-DCIPFFRSAPSCPQNKNRV---RNQINALTSFVDASMVYGSEVSLSLR 324

  Fly   352 ------------------DNARVFRHGLLVYGRGDPAEDVC---QRGAIATKCIRSGDGRSGEQP 395
                              ||.|    .||.:  .:..:|.|   .|.| ...|..:||.||.|.|
Human   325 LRNRTNYLGLLAINQRFQDNGR----ALLPF--DNLHDDPCLLTNRSA-RIPCFLAGDTRSTETP 382

  Fly   396 GLLAMHHVWVGEHNRIAMELSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGREVVKLF 460
            .|.|||.:::.||||:|.||..|||.|:.:|:|.|.|:|:|||.|.||:|:|||::||:...:
Human   383 KLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGKARAR-- 445

  Fly   461 DLELMPSGYYERYSSKVNPTVANAFAAAAFRFGHSLVQNSYTRCDRHH--NVINNNVSLHEE-FQ 522
                ...|:|..|.|.|:|.|||.| ..||||||:::|....|.|..:  :..|::|.|... |.
Human   446 ----RTLGHYRGYCSNVDPRVANVF-TLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSAFFA 505

  Fly   523 RGDIGSAGSLHRLLRGLASQRAL--KRDEFITPELTNHLFQTPGFPFGLDLAAINIQRGRDHGIA 585
            ...|...|.:..:||||.:..|.  ::|..:..||.:.||:... ..||||||:|:||.||||:.
Human   506 SWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVR-RIGLDLAALNMQRSRDHGLP 569

  Fly   586 PYSAWRVPCGLSPILSWDDFANVV-GPESAKRIGHAYRSVHDIDLFVGGIAERPVVGGLVGPTFA 649
            .|:|||..||||...:....:.|: ..:.|::..:.|.:..:||:::|.|||..:.|..|||..|
Human   570 GYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLA 634

  Fly   650 CIIAQQFSNSRRGDRFWYENGGFESSFTPAQLHSLRRVSLAQVLCRTVGGGTLQPHIF----IPA 710
            |:...||..:|.|||||::..|.   ||..|..:|.|:||::::|...|..|:...||    .|.
Human   635 CLFENQFRRARDGDRFWWQKRGV---FTKRQRKALSRISLSRIICDNTGITTVSRDIFRANIYPR 696

  Fly   711 EFEDNERQTCGVGSLSPIDLSPW 733
            .|.:..|       :..::||.|
Human   697 GFVNCSR-------IPRLNLSAW 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	208/573 (36%)
		LHP1	731..>871	CDD:227520	2/3 (67%)
EPX	NP_000493.1	myeloperoxidase_like	289..699	CDD:188656	154/430 (36%)