Protein Alignment CG42331 and Tpo

DIOPT Version :10

• Sequence 1: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: NP_062226.2
• Gene: Tpo / 54314
• RGDID: 3900
• Length: 914
• Species: Rattus norvegicus
• Alignment Length: 739
• Identity: 233/739 - (31%)
• Similarity: 338/739 - (45%)
• Gaps: 129/739 - (17%)

  Fly    95 MLRNGQTLQDN----------------HPAAMLSRFNAPTTDSERREMAAYATIAAAKAFRKNFQ 143
            ::...|.|.||                .||.:||....|       |..:.|...||:....:.|
  Rat    42 VVETSQLLVDNAVYNTMKRNLKKRGVLSPAQLLSFSKLP-------ESTSGAISRAAEIMETSIQ 99

  Fly   144 HIDELARQSHTQRISLRRTA----LEG----LCPPRDPPPCMPASERYRTHDGTCNNKRRPRWGA 200
            .:.....|..|..:|....|    |.|    :.|||.|..|:  :.:||...|.|||:..|||||
  Rat   100 VMKREQSQFSTDALSADILATIANLSGCLPFMLPPRCPDTCL--ANKYRPITGVCNNRDHPRWGA 162

  Fly   201 AQMPFNRFLPPEYGDGVDTVRS-----SADGSTLSSSRFVSL-LVHGAREG---EAPLTLMIAQW 256
            :.....|:|||.|.||....|.     ...|..|...|.|:. |:..:.|.   :...:..:..|
  Rat   163 SNTALARWLPPVYEDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSDFLPVW 227

  Fly   257 GQMLDHDMTSTAQPRSINGSIPSCCGGKDF-------HPACFPIKVPLDDPWLAPLKVRCLEFLR 314
            ||.:|||:..|.|    :.|..:..||.|.       :| ||||::|.:    :.....||.|.|
  Rat   228 GQYIDHDIALTPQ----STSTAAFWGGVDCQLTCENQNP-CFPIQLPSN----SSRTTACLPFYR 283

  Fly   315 SAPAQRRDC-------------VLSWREQTNQVTSYIDASPIYSNS-------AKSSDNARVFRH 359
            |:.|    |             ..:.|:|.|.:||::|||.:|.:|       ...|.:|.:.|.
  Rat   284 SSAA----CGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRV 344

  Fly   360 GLLVYGRG-------------DPAEDVCQRGAIATKCIRSGDGRSGEQPGLLAMHHVWVGEHNRI 411
            ..|....|             :|......|    |.|..:||||:.|.|.|.|:|.:|:.||||:
  Rat   345 NTLHLDSGRAYLPFASAACAPEPGAPHANR----TPCFLAGDGRASEVPALAAVHTLWLREHNRL 405

  Fly   412 AMELSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGREVVKLFDLELMPSGYYERYSSK 476
            |.....:|.|||....|||.|::|||:.|.||.|:::|.|||.:..:.:      .|.||.|:..
  Rat   406 ATAFKAINTHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQY------VGPYEGYNPT 464

  Fly   477 VNPTVANAFAAAAFRFGHSLVQNSYTRCD---RHHNVINNNVSLHEEFQR-GDIGSAGSLHRLLR 537
            |||||:|.|:.|||||||:.|.....|.:   :.|..: ..:.||:.|.| ..:...|.|..::|
  Rat   465 VNPTVSNVFSTAAFRFGHATVHPLVRRLNTDFQDHTEL-PRLQLHDVFFRPWRLIQEGGLDPIVR 528

  Fly   538 GLASQRA--LKRDEFITPELTNHLFQTPGFPFGLDLAAINIQRGRDHGIAPYSAWRVPCGLSPIL 600
            ||.::.|  ..:::.:..|||..||...... .||||::|:|||||||:..|:.||..||||.:.
  Rat   529 GLLARPAKLQVQEQLMNEELTERLFVLSNVG-TLDLASLNLQRGRDHGLPGYNEWREFCGLSRLE 592

  Fly   601 SWDDFANVVGPES-AKRIGHAYRSVHDIDLFVGGIAERPVVGGLVGPTFACIIAQQFSNSRRGDR 664
            :..:....:...| ..:|...|:...:||:::||:||:.:.|...||.|||||.:|....|.|||
  Rat   593 TPAELNKAIANRSMVNKIMELYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDR 657

  Fly   665 FWYENGGFESSFTPAQLHSLRRVSLAQVLCRTVGGGTLQPHIF----IPAEFEDNERQTCGVGSL 725
            ||:||   ...||.||...|.:.||.:|:|...|...:....|    .|.:||..|       .:
  Rat   658 FWWEN---SHVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESCE-------EI 712

  Fly   726 SPIDLSPWLEQDPFHNQQV-PEQV 748
            ..:||..|.|..|..::.| ||:|
  Rat   713 PSMDLRLWRETFPQDDKCVFPEKV 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	194/579 (34%)
		LHP1	731..>871	CDD:227520	7/19 (37%)
Tpo	NP_062226.2	thyroid_peroxidase	161..722	CDD:188657	193/595 (32%)
		CCP	730..783	CDD:153056	4/7 (57%)
		EGF_CA	784..813	CDD:429571
		FXa_inhibition	<802..826	CDD:464251
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..907