Protein Alignment CG42331 and Duox1

DIOPT Version :10

• Sequence 1: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: NP_714961.2
• Gene: Duox1 / 266807
• RGDID: 628760
• Length: 1551
• Species: Rattus norvegicus
• Alignment Length: 872
• Identity: 209/872 - (23%)
• Similarity: 335/872 - (38%)
• Gaps: 225/872 - (25%)

  Fly   187 DGTCNNKRRPRWGAAQMPFNRFLPPEYGDGV-DTVRSSADGSTLSSSRFVSLLVHGAREGEAPL- 249
            ||..||....|||:......|.:|..|.||| ..:|.    ..|.:.|.:|..|.....|:..|
  Rat    33 DGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLRE----PYLPNPRHLSNRVMRGPAGQPSLR 93

  Fly   250 --TLMIAQWGQMLDHDMTSTAQPRSINGSIPSCCGGKDFHPACF-PIKVPLDDPWLAPLKVR--C 309
              |::...:|..:..|:.|.        ..|.|       ||.| .|.:|..||...|.|..  .
  Rat    94 NRTVLGVFFGYHVLSDLVSV--------ETPGC-------PAEFLNIYIPRGDPVFDPDKRGNVV 143

  Fly   310 LEFLRS--------APAQRRDCVLSWREQTNQVTSYIDASPIYSNSAKSSDNARVFRHGLLVYGR 366
            |.|.||        :|:..||.       |||||.::|.|.||.:|...||..|.|..|.|..|
  Rat   144 LPFQRSRWDRSTGQSPSNPRDL-------TNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASG- 200

  Fly   367 GDPAEDVCQRGAI--------ATKCIRSGDG-----------RSGEQPGLLAMHHVWVGEHNRIA 412
            .|||.....:.::        ||     |.|           |...:|.|.|:..:|...||..|
  Rat   201 PDPAFPRNSQNSLLMWMAPDPAT-----GQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCA 260

  Fly   413 MELSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGREVVKLFDLELMPSGYYERYSSKV 477
            ..|::.:|||.||:::|..|:.|.|.:|:|...|:||..|.:...:           |..|...:
  Rat   261 KRLAQEHPHWGDEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPE-----------YPGYHPFL 314

  Fly   478 NPTVANAFAAAAFRFGHSLV-QNSYTRCDRHH--NVINNNVSL--------------HEEFQRGD 525
            :|:::..|..|:.:|..::| ...|.|....|  .:.|.|.|:              :.:.||
  Rat   315 DPSISPEFVVASEQFLSTMVPPGVYMRNASCHFQGIANRNSSVSGALRVCNSYWSRENPKLQR-- 377

  Fly   526 IGSAGSLHRLLRGLASQRALKRDEFITPELTNHLFQTPG-FPFG-LDLAAINIQRGRDHGIAPYS 588
               |..:..||.|:|||.|.:.|..:..::.:.   .|| ..|. .|..|..:|||||.|:..|:
  Rat   378 ---AEDVDALLLGMASQIAEREDHLVVEDVQDF---WPGPLKFSRTDYLASCLQRGRDLGLPSYT 436

  Fly   589 AWRVPCGLSPILSWDDFANVVGPESAKRIG---HAYRSVHD-----IDLFVGGIAERPVVGGLVG 645
            ..|...||.|:..|.|    :.|..::..|   .|..::::     ::|..||:.|.   .|..|
  Rat   437 KAREALGLPPVSHWQD----INPALSRSNGTVLEATAALYNQDLSRLELLAGGLLES---HGDPG 494

  Fly   646 PTFACIIAQQFSNSRRGDRFWYENGGFESSFTPAQLHSLRRVSLAQVL--CRTVGGGTLQPHIFI 708
            |.|:.|:..||...|.|||:|:||.. ...|:..::..:|..||..:|  ...|....|||.:|.
  Rat   495 PLFSAIVLDQFVRLRDGDRYWFENNR-NGLFSKEEIAEIRNTSLRDILVAVTNVDPSALQPSVFF 558

  Fly   709 ---------PAEFEDNERQTCG------------------VGSLS--PID--LSPW----LEQDP 738
                     |::........|.                  :|:|.  |:.  ||.|    |....
  Rat   559 WLAGDPCPQPSQLSTQGLPACAPLFVRDYFKGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRMRN 623

  Fly   739 FHNQQVPEQVFTIGQPELGSVQIIKEDKAGFSNRVKPIKP-QVEVSPSSLSGFHRPTNENLTKVS 802
            |...|..::...:.:..:|.|:.::     :..|.:|.:| .|.:.|..:    |..:..|| |.
  Rat   624 FKRLQRQDRQSIMCEKLVGGVEALE-----WQGRKEPCRPVLVHLQPGQI----RVVDGRLT-VL 678

  Fly   803 DKLDLRRKTVTKKNNTNNRQQTTRKPVGGVNNKLDKSPK-----ITLNIKSVNVRRPEGSGLKRR 862
            ..:.||.........::||         |....|.|.||     :..|::.           :|:
  Rat   679 RTIQLRPPQQVNLILSSNR---------GRRTLLLKIPKEYDLVLLFNMEE-----------ERQ 723

  Fly   863 VIINNVPVELRSSGGNATAEETEPGNLTDEDDEFHDDAGEVVDMEDIVEVRASKDDPSKLTKT-- 925
            .::.|:...|:.:|            |:.::.|..:        ::::....::.....|.:|
  Rat   724 ALVENIRAALKENG------------LSFQEWELRE--------QELMRAAVTRQQRGHLLETFF 768

  Fly   926 --------DLNQNRNDSKTTETEQTEK 944
                    |:||  .|:.|...:.:.|
  Rat   769 RHLFSQVLDINQ--ADAGTLPLDSSTK 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	162/582 (28%)
		LHP1	731..>871	CDD:227520	28/149 (19%)
Duox1	NP_714961.2	Peroxidase-like, mediates peroxidase activity. /evidence=ECO:0000250	26..593		165/618 (27%)
		dual_peroxidase_like	32..591	CDD:188652	165/616 (27%)
		EFh	820..881	CDD:238008
		EF-hand_7	853..925	CDD:463900
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248
		Ferric_reduct	1087..1236	CDD:426438
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783