Protein Alignment CG42331 and Duox2

DIOPT Version :10

• Sequence 1: NP_651282.2
• Gene: CG42331 / 42948
• FlyBaseID: FBgn0259233
• Length: 1615
• Species: Drosophila melanogaster
• Sequence 2: NP_001349684.1
• Gene: Duox2 / 214593
• MGIID: 3036280
• Length: 1545
• Species: Mus musculus
• Alignment Length: 800
• Identity: 195/800 - (24%)
• Similarity: 310/800 - (38%)
• Gaps: 211/800 - (26%)

  Fly   171 RDPPPCMPASERYRTHDGTCNNKRRPRWGAAQMPFNRFLPPEYGDGVDTVRSSADGSTLSSSRFV 235
            :|.|......:||   ||..||.:..:.|||.....|.:|..|.||   |..:.:...|.:.|.:
Mouse    26 QDAPSLPWEVQRY---DGWFNNLKYHQRGAAGSRLRRLIPANYADG---VYQALEEPLLPNPRRL 84

  Fly   236 SLLVHGAREGEAPL------TLMIAQWGQMLDHDMTSTAQPRSINGSIPSCCGGKDFHPACF-PI 293
            |   ....:|:|.|      |::...:|..:..|:.|.        ..|.|       ||.| .|
Mouse    85 S---DAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSV--------ETPGC-------PAEFLNI 131

  Fly   294 KVPLDDPWLAPLKVR--CLEFLRS--------APAQRRDCVLSWREQTNQVTSYIDASPIYSNSA 348
            .:|..||...|.|..  .|.|.||        :|:..||       |:||||.::|.|.||.:|.
Mouse   132 YIPRGDPVFDPDKRGNVVLPFQRSRWDHNTGQSPSNPRD-------QSNQVTGWLDGSAIYGSSH 189

  Fly   349 KSSDNARVFRHG-----------------LLVY-------GRGDPAEDVCQRGAIATKCIRSGDG 389
            ..||..|.|..|                 ||::       |||.|      :|..|     .|..
Mouse   190 SWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGP------QGVYA-----FGAQ 243

  Fly   390 RSGEQPGLLAMHHVWVGEHNRIAMELSELNPHWSDEKVYQETRRIVGAMFQHITFREFLPVILGR 454
            |...:|.|.|:..:|...||..|.:|::.:|||.||:::|..|:.|.|.:|:|...::||..|.:
Mouse   244 RGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQK 308

  Fly   455 EVVKLFDLELMPSGYYERYSSKVNPTVANAFAAAAFRFGHSLVQNSYTRCDRHHNVINNNVSLH- 518
            ...:           |..|...::|:::..|..|:.:|..::|.         ..|...|.|.|
Mouse   309 TPPE-----------YSGYRPFMDPSISPEFVVASEQFLSTMVP---------PGVYMRNSSCHF 353

  Fly   519 EEF--------------------QRGDIGSAGSLHRLLRGLASQRALKRDEFITPELTNHLFQTP 563
            .:|                    :..::.:|..:.:||.|:|||.:...|..:..:|.::   .|
Mouse   354 RKFPKEGSDSSPALRVCNSYWIRENPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDY---WP 415

  Fly   564 GFP--FG-LDLAAINIQRGRDHGIAPYSAWRVPCGLSPILSWDDFANVVGPESAKRIGHAY-RSV 624
            | |  |. .|..|.:||||||.|:..||...:..||.|..:|......|.|:..:.....| :.:
Mouse   416 G-PERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDL 479

  Fly   625 HDIDLFVGGIAERPVVGGLVGPTFACIIAQQFSNSRRGDRFWYEN--GGFESSFTPAQLHSLRRV 687
            ..::|.:||:.|.   .|..||.|:.||..||...|.|||:|:||  .|.   |:..::..:|..
Mouse   480 SQLELLLGGLLES---HGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGL---FSKEEIAEIRNT 538

  Fly   688 SLAQVL--CRTVGGGTLQPHIFIPAEFEDNERQTCGVGSLSPIDLSPWLEQDPFHNQQVPEQVFT 750
            :|..||  ...|....|||::|.                        |.|..|...   |.|:.|
Mouse   539 TLRDVLVAVSNVDPSALQPNVFF------------------------WQEGAPCPQ---PRQLTT 576

  Fly   751 IGQPELGSVQII---KEDKAGFSNRVKPI--KPQVEVSPSSLSGFHRPTNENLTKVSDKLDLRRK 810
            .|.|:...|.:|   :...||:...:..:  .|.|.:..:.:....|             :...|
Mouse   577 DGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFR-------------NREHK 628

  Fly   811 TVTKKNNTNNRQQTTRKPVGGVN--NKLDKSPKITLN----------------IKSVNVRRPE-- 855
            .:.||...:.::|.....|..:.  ...:||..:||.                ::::.::.|:
Mouse   629 MLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQV 693

  Fly   856 ----GSGLKRRVIINNVPVE 871
                .|...||.::..:|.|
Mouse   694 NLILSSNSGRRTLLLKIPKE 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42331	NP_651282.2	An_peroxidase	183..707	CDD:460804	161/593 (27%)
		LHP1	731..>871	CDD:227520	29/168 (17%)
Duox2	NP_001349684.1	dual_peroxidase_like	38..594	CDD:188652	172/654 (26%)
		EFh	824..885	CDD:238008
		EFh	861..919	CDD:238008
		Ferric_reduct	1081..1230	CDD:426438
		NOX_Duox_like_FAD_NADP	1271..1545	CDD:99783