DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asp and AT4G21820

DIOPT Version :9

Sequence 1:	NP_524488.3	Gene:	asp / 42946	FlyBaseID:	FBgn0000140	Length:	1954	Species:	Drosophila melanogaster
Sequence 2:	NP_001329536.1	Gene:	AT4G21820 / 828270	AraportID:	AT4G21820	Length:	1284	Species:	Arabidopsis thaliana

Alignment Length:	1631	Identity:	315/1631 - (19%)
Similarity:	559/1631 - (34%)	Gaps:	574/1631 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 SPVKNPHKRRSHELSFSDAPSNESLYRNETVAISPPKKQRVEDTTLPRSAAPANASARSSSAHAW 545
            :|.:||......::|....|...|:. |..::.||...........|:|:  ::...|.|..|::
plant    12 APPRNPASSLLSDISNFKTPRRTSVV-NSNISKSPYPHFFTASKQTPKSS--SSNFRRPSMVHSY 73

  Fly   546 PHAQS--------KKFKLAQTMSLMKKPATPRKVRDTSIQPSVKLYDSELYMQTCINPDPFAATT 602
            .....        |.|:|.|:.|..|...|..|                       |....|.:.
plant    74 ASRSKVSTSSRRLKAFELQQSQSSRKAELTKEK-----------------------NLRSLAKSL 115

  Fly   603 TIDPFLASTMYLDEQAVDRHQADFKKWLNALVSIPADLDAD-LNNKIDVGKLFNEVR-------N 659
            |:                        |||.|...|.:...| ..|:..||.|....|       |
plant   116 TV------------------------WLNFLFENPENCGCDPFENESGVGNLGKGKRDSGEALGN 156

  Fly   660 KELVVAPT-----------------KEEQSMNYLTKYRLETLRKAAVELFFSEQMRLPCS----- 702
            .:.|...|                 |..:..:.||..:..|||         |.:|..||
plant   157 SKSVGVDTMWRSPKRLRNLGWCGEKKRSEIDSSLTGSKYSTLR---------ESLRDVCSLDDLK 212

  Fly   703 --------------------KVAVYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGL 747
                                :|:..:::..::::....|..|..|:...::.|:.:|.:||||||
plant   213 QRMQFHLSLGSCKEIFDVMTRVSKNIDEGRIKMKPQCPLVTDFGMKEKAIKALMSYNQVWLRLGL 277

  Fly   748 EVVFG-----EKIQMQSNRDIVGLSTFILNRLFR----------NKCEEQRYSKAYTLTEEYAET 797
            .::||     ...::.|::::..|...|..:.|.          ||..|..|...      |.|.
plant   278 YIIFGGDSFLSDSEVNSDQEMAFLKMVISKQFFSHDGLARSYVYNKMVEGLYRPG------YYEA 336

  Fly   798 IKKHSLQKILFLLLFLDQAKQKRIVK----------HNPCLFVKKSPHKETKDILLR-FSSELLA 851
            :....|::||.|:|.:|:||.:..:.          .:|.:|.:||..|.:..::.. .||:::.
plant   337 LGNVILKRILLLVLVIDRAKSQSCLSLKYGIDGIDGGSPLMFSEKSSIKSSHQLICELLSSDVMH 401

  Fly   852 NIGDITRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDGVRLTRVMEVILLRDDLTRQLRVPAI 916
            ..|::...|..:||.:.::|:.|.|:::....|..||:|||||.|.::::|....:..::.||:.
plant   402 GEGNLLAHLVIIGYKIPYQQSPLVEYNFRVRELFADLQDGVRLCRAIQLLLHDPSILTKMVVPSD 466

  Fly   917 SRLQRIFNVKLALGALGEANFQLGGD----IAAQDIVDGHREKTLSLLWQLIYKFRSPKFHAAAT 977
            :|.:.:.|.::||..|.:|...|..|    |..:|:.||.||.|:||||.:....:.|
plant   467 NRKKNLANCRIALQYLKDAGVSLKDDEGMMITGEDVADGDRELTISLLWNIFVHLQLP------- 524

  Fly   978 VLQKWWRRHWLHVVIQRRIRHKELMRRHRAATVIQAVFRGHQMRKYVKL---------------F 1027
                        ::|..|:..:|:.:       :|.|.:.:|:.....|               |
plant   525 ------------LLINGRLLTEEIYK-------VQGVEQNNQITMSTPLEMLLNWIQSITRKNDF 570

  Fly  1028 KTERTQAAI-------ILQKFTRRYLAQKQLYQ----------------SYHSIITIQRWWRAQ- 1068
            |.|...:.:       :|..:.|:.:..:.|::                .||.  .:|.:..:|
plant   571 KLESFASLVDGKGIWFLLDYYFRQEVCCRCLHREDPGGQEGPQSVMSNTDYHD--AVQNFILSQK 633

  Fly  1069 ------------QLGRQHRQRFVELREAAIFLQRIWRRRLFAKKLLAAAETARLQRS--QKQQAA 1119
                        |:|.......|...::.|.|......:|..|:.|......:|..|  |.|:..
plant   634 LTALLGSFPEVLQIGDLLEHNAVVSNQSVIILLAFLSSKLIVKENLEQLNFHKLLCSSCQVQEKR 698

  Fly  1120 ASYIQMQWRSYQLGRIQRQQFLRQRDLIMFVQRRMRSKWSMLEQRKEFQQLKRAAINIQQRWRAK 1184
            .|.|::...|.:...|:........|.....| .:::.|..:..:.:....|..:..:|    ..
plant   699 YSRIRISCSSSEAVTIEEPDRENGEDATKRFQ-AIKAWWQDMANQNQISVGKANSHTLQ----GS 758

  Fly  1185 LSMRKCNAD----YLAL--------RSSVLKVQAYRKATIQMRIDRNHYYSLRKNVIC-LQQRLR 1236
            || |||..|    ||.|        :|::..:.|.||...:||            .|| ||..:|
plant   759 LS-RKCTTDSQRAYLLLAEIAAVIIQSNIRGLHARRKFRNKMR------------AICFLQAAVR 810

  Fly  1237 AIMKMR----------EQRENYLRLRNASILVQKRYRMRQQMIQDRNAYLRTRKCIINVQRRWRA 1291
            ..:.::          |:...:|..|:|::....||   .:.|.||:.:::.||.:..:|:
plant   811 TWLSVKNIQVVEKFNVEEVTLHLSERSANLKPVARY---VKFIVDRSRFIKLRKSVSVIQK---- 868

  Fly  1292 TLQMRRERKNYLHLQTTTKRIQIKFRAKREMKKQRAEFLQLKKV--TLVVQKRRRALLQMRKERQ 1354
              .:||.:.|..|......|||:.:|:.:|            ||  ::.:|...|..:..|..|
plant   869 --AVRRHQSNLHHELKAALRIQLAWRSYKE------------KVISSITIQSYVRGWITRRMNR- 918

  Fly  1355 EYLHLREVTIKLQRRFHAQKSMRFMRAKYRGTQAAVSCLQMHWRNHLLRKRERNSFLQLRQAAIT 1419
                    |.|.                      :...:|.:.|..|.|::    |...|:|.|:
plant   919 --------TYKF----------------------SSILIQRYCRGWLARRK----FCLQREATIS 949

  Fly  1420 LQRRYRARLNMIKQLKSYAQLKQAAITIQTRYR---AKKAMQKQVVLYQKQREAIIKVQRRYRGN 1481
            :|...| :.|.   :.|:.:.|.||..:|...|   .:..:|....||.|..|.:.::.:...|
plant   950 IQSAIR-KFNC---MMSFHRCKHAATQVQRLVRGQIVRSRLQGASTLYSKLDEGVSRLPQHSFG- 1009

  Fly  1482 LEMRKQIEVYQKQRQAVIRLQKWWRSIRDMRLCKAGYRRIRLSSLSIQRKWRATVQARRQREIFL 1546
              |.|.:       .:||::|:|||.
plant  1010 --MTKML-------HSVIKVQRWWRE--------------------------------------- 1026

  Fly  1547 STIRKVRLMQAFIRATLLMRQQRREFEMKRRAAVVIQRRFRARCAMLKARQDYQLIQSSVILVQR 1611
                       |:.:.          .|:.::||:||.
plant  1027 -----------FLHSK----------NMRIKSAVLIQS--------------------------- 1043

  Fly  1612 KFRANRSMKQARQEFVQLRTIAVHLQQKFRGKRLMIEQRNCFQLLRCSMPGFQARARGFMARKRF 1676
                                   |::..|..::..:|:.|..
plant  1044 -----------------------HIRGLFARRKTSVERHNIV----------------------- 1062

  Fly  1677 QALMTPEMMDLIRQKRAAKVIQRYWRGYLIRRRQKHQGLLDIRKRIAQLRQEAKAVNSVRCKVQE 1741
                               :||.:|||||.|:..|.| :||:|     :|.:..|.|     :.:
plant  1063 -------------------MIQSHWRGYLTRKASKAQ-VLDLR-----VRMQTSAAN-----IDD 1097

  Fly  1742 AVRFLRGRFIASDALAVLSRLDRLS-RTVPHLLMWCSEFMSTFCYG------------------I 1787
            ..|.:      :..|:.||.|  || :.|.::|..|....|...|.                  :
plant  1098 KKRLI------NKLLSALSEL--LSMKNVHNILHICETLESATKYSDKCCEELVAAGAIEKLLTL 1154

  Fly  1788 MAQAIRSEVDKQLIERCSRIILNLARYNSTT---VNTFQEGGLVTIAQMLLRWCDKD------SE 1843
            :..|.||..|:|:.:.....:.:||||....   :||  :|.:.||...|||  :|:      |:
plant  1155 IRSASRSIPDQQVSKHALSTLGHLARYPQMADELINT--KGSIQTIFWELLR--NKEEAYFIASD 1215

  Fly  1844 IFNTLCTL---IWVFAHCPKKRKIIHDYMTNPEAIYMVRE-TKKLVARKEKMKQNARKPPPMTSG 1904
            :...:|:.   :......|...|.:|         .:|.| |:|....|..:|..        :|
plant  1216 VLKKICSSHKGVEAVRKLPALVKRLH---------VLVEELTRKANIEKRNVKGQ--------TG 1263

  Fly  1905 RYKSQK 1910
            :.||::
plant  1264 KEKSER 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asp	NP_524488.3	ASH	26..122	CDD:292408
		CH	866..968	CDD:237981	34/105 (32%)
		TPH	1066..1435	CDD:290579	82/408 (20%)
		IQ	1689..1711	CDD:197470	8/21 (38%)
AT4G21820	NP_001329536.1	CH	430..518	CDD:366016	31/87 (36%)
AT4G21820	NP_001329536.1	COG5022	<778..1250	CDD:227355	135/737 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3970
eggNOG	1	0.900	-	-		E1_KOG0165
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I1490
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D482623at2759
OrthoFinder	1	1.000	-	-		FOG0005407
OrthoInspector	1	1.000	-	-		oto3343
orthoMCL	1	0.900	-	-		OOG6_104698
Panther	1	1.100	-	-	LDO	PTHR22706
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870