DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment asp and aspm

DIOPT Version :9

Sequence 1:NP_524488.3 Gene:asp / 42946 FlyBaseID:FBgn0000140 Length:1954 Species:Drosophila melanogaster
Sequence 2:XP_005161794.1 Gene:aspm / 554173 ZFINID:ZDB-GENE-050208-620 Length:3411 Species:Danio rerio


Alignment Length:2479 Identity:570/2479 - (22%)
Similarity:948/2479 - (38%) Gaps:796/2479 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 SRLKQKKRAEGREPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDDDIEVKVMKAIREEH 75
            ||.|..|......| |:.:..||....|.|..:.:..:....:|:.||:||.....::..|....
Zfish    22 SRDKSGKENSSSIP-VLSLLQFSRAPFVSFGTIKLGSSKSLPLRIENPTDDATATVIVDKISASK 85

  Fly    76 NLSLEWMEHTVPARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSKSNQ-------- 132
            ..|::.|..|:...|.:.:.:.|:||.|...:|.|..|.|...:.:.:::.|:::.:        
Zfish    86 GFSVDQMSFTIQPEDSIILTVTWTPVEEGGIRELLCFIANGIVKHQAILLGKAETTKKKKKTLWD 150

  Fly   133 PVKNPRKFPTVGK-----TLQLKSPTGAGKTMKSVVSAAVQQKKRMSAAAAPPSKQ--TWRVTAP 190
            .:|:.:..|...|     |:.:||   ..||..  ||...|.:|..::....|..|  :.||..|
Zfish   151 SIKSKKGVPAPSKEKKVSTMPIKS---VNKTFH--VSRQSQYRKDRTSNPLSPLNQNGSRRVNTP 210

  Fly   191 S------RPAAW------AHPPPQAPLV----EKNVYKTPQEEPVYISPQ------PRSLKENLS 233
            |      :||..      .|....:|:|    .:.:..||.::....|.|      .|.|.:.||
Zfish   211 SSTPEMPKPAFITETFDNVHLQKDSPVVVLVPAERLLDTPGKKDAPSSRQIECREITRVLNKTLS 275

  Fly   234 P-MTPGNL-----------LDVI-----DNLRFTPLTETRGKGQATIFPDNLAAWPTP------- 274
            | .||...           |.||     |..|.........|....:...:|:...:|       
Zfish   276 PASTPERFRNPLSSGFQSPLPVIGQFVQDKSREPEKLSLSVKDALDVIGSDLSHTVSPPNACSSF 340

  Fly   275 ----TLKGNVKSCANDMRPRRITPDDLEDQPATNKTFDVKHSETINISLDTLDCSRIDGQPHTPL 335
                :|:.:........|.||:....:|... ...||.||.::.|.|: ...|..|:...|.:..
Zfish   341 DFSDSLESDKPDPGASFRARRVISPPVETAD-PRLTFCVKPNKAIGIA-SNQDEFRLKALPFSTA 403

  Fly   336 NKTTTI-VHATHTRALACIHEEEGPSPPRT-PTKSA-IHDLKRDIKLVGSPLRK----------- 386
            ..|.:| |..||.           |..|:| |..|| :...|.|..:....|||           
Zfish   404 TVTKSIKVDDTHV-----------PDDPKTFPVNSATVVKSKADASVESPGLRKKKTSRRRLLEK 457

  Fly   387 --------------------------YSESMKDLSL---------------LSPQTKYAIQGS-- 408
                                      .|:|..||.|               |||..:.....|  
Zfish   458 TLELSEPSNAESNTSSPDSFSALPVINSDSSPDLPLESKICPVAKKKPTLNLSPHDQLLSSISPI 522

  Fly   409 ----MPNLNEMKIRSIEQNRYY---------QEQQIQIKAKDLNSSSSSEASLAGQQEFLFNHSE 460
                .|:::.....|:|.:..:         .|.|..::::.|..|...::     .|||..|||
Zfish   523 RPQVFPSVSNSPSSSLELSASHFSEKVKPNLLENQFPVQSRTLVQSKKRKS-----DEFLRGHSE 582

  Fly   461 ----ILAQSSRFNLHEVGRKSVKGSPVKNPHKRRSHELSFSDAPSNESLYRNETVAISPPKKQRV 521
                |.|:..|          ......:.|.:.|:.....:..|..:        |::||..::.
Zfish   583 DKSNIQAKKCR----------APAQATEKPSQERTLTSRSTSGPQRK--------AVAPPSSRKF 629

  Fly   522 EDTTLPRSAAPANASARSSSAHAWPHAQSKKFKLAQTMSLMKKPATPRKVRDTSIQPSVKLYDSE 586
            .... |:..:|..|...:.|..:   |.|...|.|:.:::       .:.|.|.::|:       
Zfish   630 TRFP-PKKISPKTAQKDARSVKS---ANSSTRKTARIVAV-------AQARLTFMKPT------- 676

  Fly   587 LYMQTCINPDPFAATTTIDPFLASTMYLDEQAVDRHQADFKKWLNALVSIPADLDADL------- 644
               ||.|...|.       ||.|..|:.||:.:::.:..|..|:|.::: |.|.....       
Zfish   677 ---QTAIPRHPL-------PFAAKNMFYDERWIEKQERGFTWWMNYILT-PDDFKVATEVTKVNA 730

  Fly   645 ------NNKIDVGKLFNEVRNKELVVAPTKEEQSM-NYLTKYRLETLRKAAVELFFSEQMRLPCS 702
                  |:|.::.|            ||||||.|. .|..:.||..||:||.:||.||.|.....
Zfish   731 LSLTMGNDKFNIPK------------APTKEEMSFRTYTARQRLNRLRRAACKLFTSEAMVKAIQ 783

  Fly   703 KVAVYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGLEVVFGEKIQMQSNRDIVGLS 767
            ::.:.|..:.|.:|.||:|..|:..::.:|..|:.:||||||:|||.::||.|.::||.|::||:
Zfish   784 RLELEVEAKRLLVRKDRHLWKDIGERQKVLNWLISYNPLWLRIGLETIYGELISLESNNDVMGLA 848

  Fly   768 TFILNRLFRNK--CEEQRYSKA-YTLTEEYAETIKKHSLQKILFLLLFLDQAKQKRIVKHNPCLF 829
            .|||.||..|.  ..|.|:||. :...:.:.|.:.:.:|:|::.|:.|||:||:.|:::|:||||
Zfish   849 MFILGRLLWNPDLAAEFRHSKVPHLYRDGHEEALSRFTLKKLILLVCFLDKAKESRLIEHDPCLF 913

  Fly   830 VKKSPHKETKDILLRFSSELLANIGDITRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDGVRL 894
            ...:..|.:||:||.||.:.|:..|.::|.|..||..:.|.||.||||::|...|||||:.|:||
Zfish   914 CMDAEFKSSKDLLLAFSRDFLSGEGILSRHLSHLGLAVSHVQTPLDEFNFAVKKLAVDLKCGIRL 978

  Fly   895 TRVMEVILLRDDLTRQLRVPAISRLQRIFNVKLALGALGEANFQL----GGDIAAQDIVDGHREK 955
            .||||:..|...|:|:||:|||||||::.||.|||..|......|    |.:|.::|||||||||
Zfish   979 VRVMELFTLDWTLSRKLRIPAISRLQKVHNVDLALQVLKNKGVDLRDEHGANIDSRDIVDGHREK 1043

  Fly   956 TLSLLWQLIYKFR--------------------------------------------------SP 970
            ||:|||::|:.|:                                                  |.
Zfish  1044 TLNLLWKIIFAFQVEVLLDENQLKEEISFLRKTWRTKQKLASIMANNSVTVSRMKARRAFEHPSQ 1108

  Fly   971 K-------------------------------------------FHA------------------ 974
            |                                           .||                  
Zfish  1109 KVTLLMDWVNAVCEFYSLKAENFTVSFSDGRILCYLIHHYHPGHLHAEEIQQRTTQTIECGHRGR 1173

  Fly   975 ----------------------------------------------------------------- 974
                                                                             
Zfish  1174 VELNNSSSDSDCSFENLATMQSESVTVDFRELLENEKSNFQLVNTAVSYLGGVPAMINPEDMSNT 1238

  Fly   975 --------------------------AATVLQKWWRRHWL-----------------HVVIQRRI 996
                                      ||.|:|..|||:.|                 ..:.::.|
Zfish  1239 IPNEKVVTCYLSFLCARLLDLRNETRAARVIQGAWRRYKLQKDIALMHEKNLAATKIQALARKFI 1303

  Fly   997 RHKELMRRHRAATVIQAVFRGHQMRKYVKLFKTER---------------------------TQA 1034
            ..:.|:|:::||..||.::||:..|:.:::.|.||                           .::
Zfish  1304 LKRRLIRQNKAAVKIQTLWRGYSAREKLRVLKKERHYALQNAAATLIQKTYKAWRVKNLLKKNRS 1368

  Fly  1035 AIILQKFTRRYLAQKQLYQSYHSIITIQRWWRAQQLGRQHRQRFVELREAAIFLQRIWRRRLFAK 1099
            |.::|...|::.|:|.|.:: .:.:.||.|:|.|...||    ::|::..|:.:|..:|..|   
Zfish  1369 AFVIQAAFRKWHAKKMLERN-TAALRIQAWYRMQLCKRQ----YLEMKRKAVCVQAWFRGHL--- 1425

  Fly  1100 KLLAAAETARLQRSQKQQAAASYIQMQWRSY----QLGRIQRQQFLRQRDLIMFVQRRMRSK--- 1157
                  :.::.|..:|:..|:..||..:|:|    :|.::::...|.||.....|||:...|   
Zfish  1426 ------QRSKFQNLKKRHHASVVIQSAFRAYLIRKELSKMKQNAVLIQRWFRACVQRKAEQKRYF 1484

  Fly  1158 ---------------WSMLEQ--------------------RKEFQQLKRAAINIQQRWRAKLSM 1187
                           |.:.:.                    ::.|..|||:||.:|||:|||:..
Zfish  1485 EIKSAVLVLQAAFRGWKVRKSVAQHHRSALVIQTAFRRFTAQRHFLCLKRSAIVLQQRYRAKVHG 1549

  Fly  1188 RKCNADYLALRSSVLKVQAY------RKATIQM-------------RIDRNHYYSLRKNVICLQQ 1233
            .|...:|:||:|:.:::||.      ||...|:             .:::..:..:::..:.:|:
Zfish  1550 GKFRKEYMALKSASVRIQAMWRGRAERKKISQLHRFAKIIQSNYRRHLEQTRFLQMKRAAVVIQR 1614

  Fly  1234 RLRAIMKMREQRENYLRLRNASILVQKRYRMR--QQMIQDRN-------AYLRTRKC-------- 1281
            :.||....::....|.:::.|:|::|..||.|  :|.:|.:|       :.:|...|        
Zfish  1615 QYRAFRDGQKVHAEYTKIKRAAIILQSAYRGRRIRQELQRKNKAATLIQSVMRAHMCHQQFLAQK 1679

  Fly  1282 --IINVQRRWRATLQMRRERKNYLHLQTTTKRIQIKFRA-------KRE------------MKKQ 1325
              .|.:|:::||....|.||.:|:.|:..|..:|..:|.       |||            |.|.
Zfish  1680 HAAIVIQQQFRAFTFGRMERSHYMRLRKATITMQAIYRGSKVRQNLKREHQAATVIQAQFRMHKV 1744

  Fly  1326 RAEFLQLKKVTLVVQKRRRALLQMRKERQEYLHLREVTIKLQRRFHAQKSMRFMR---------- 1380
            |..|:..|...:::|:..||....:..:..||.::...:.:|..|...|...::|          
Zfish  1745 RIPFVAAKCAAILIQQHYRAYKVGKTVQATYLQMKNAAVVIQSAFRGMKVRNYLRKSHQAAKVIQ 1809

  Fly  1381 ---------AKYRGTQAAVS---------------------------CLQMHWRNHLLRK----- 1404
                     .|||..|.|.|                           |:|..:|..:.||     
Zfish  1810 AHFRGHSQLKKYRRQQWAASVLQQRFRATVTKNAVMKQYAAIKTATICIQSAFRGMVARKQIAEK 1874

  Fly  1405 --------------RERNSFLQLRQAAITLQRRYRARLNMIKQLKSYAQLKQAAITIQTRYRAKK 1455
                          ::|:.:|.||.|.|.:|::|||.::..:|.:.|..|:.||||:|:.||..:
Zfish  1875 QKCAKIIQKMYRAYKQRHDYLALRNATIRIQQQYRAVVSARQQHQRYCSLRAAAITLQSSYRGLR 1939

  Fly  1456 A-------------------MQKQVVLYQKQREAIIKVQRRYRGNLEMRKQIEVYQKQRQAVIRL 1501
            |                   |.:..|.:|..:.|.:.:||:||.:|..:|..|.:.|.:|:.:.:
Zfish  1940 ARKEINRRQKAATVIQAAYKMYRTRVPFQAMKLASLVIQRQYRCHLLRKKARENFLKLKQSAVAI 2004

  Fly  1502 QKWWRSIRDMRLCKAGYRRIRLSSLSIQRKWRATVQARRQREIFLSTIRKVRLMQAFIRATLLMR 1566
            |..:|.    :|.:....|...::..||||:    .|.:||:.||:....|...|...|:.||.|
Zfish  2005 QAIYRG----KLARRDLARRHFAATIIQRKY----LAYKQRKCFLTLQAAVIFCQQHYRSILLTR 2061

  Fly  1567 QQRREFEMKRRAAVVIQRRFRARCAMLKARQDYQ---LIQS----------------SVILVQRK 1612
            ..|:::..||||.|.||..||......:.|::::   :|||                :|..||::
Zfish  2062 HDRKDYLTKRRAVVAIQASFRGMNVRRQIRREHKAATIIQSHVRMRILNLRFQRLRWAVCTVQQR 2126

  Fly  1613 FRANRSMKQARQEFVQLRTIAVHLQQKFRGKRLMIEQRNCFQLLRCSMPGFQARARGFMARKRFQ 1677
            ||||:.|:|......:.::.|:.||..:|||:    .|...:.:..:....|:..|..:...|||
Zfish  2127 FRANKIMRQEMAALQEKKSAALILQAAYRGKK----TRQALKQMHQAATIIQSHVRMRILNLRFQ 2187

  Fly  1678 AL----------------MTPEMMDLIRQKRAAKVIQRYWRGYLIRRRQKHQGLLDIRKRIAQLR 1726
            .|                |..||..|..:|.||.::|..:||...|:..|            |:.
Zfish  2188 RLRWAVCTVQERFRANRIMRQEMAALQEKKSAALILQAAYRGKKTRQALK------------QMH 2240

  Fly  1727 QEAKAVNS-VRCKVQEAVRFLRGRFIASDALAVLSRLDRLSRTVPHLLMWCSEFMSTFCYGIMAQ 1790
            |.|..:.| ||.::.. :||.|.|:    |:..|.|..|.::                   ||.|
Zfish  2241 QAATIIQSHVRMRILN-LRFQRLRW----AVCTLQRHFRANK-------------------IMRQ 2281

  Fly  1791 AIRSEVDKQLIERCSRIILNLARYNSTTVNTF-QEGGLVTIAQ------------MLLRWCDKDS 1842
            .:.:..:|    :.:.:||..|.....|.:|. |.....||.|            ..|||     
Zfish  2282 EMAALQEK----KSAALILQAAYRGMKTRHTLKQMHQAATIIQSHVRMRILNLRFQRLRW----- 2337

  Fly  1843 EIFNTLCTL 1851
                .:||:
Zfish  2338 ----AVCTV 2342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aspNP_524488.3 ASH 26..122 CDD:292408 23/95 (24%)
CH 866..968 CDD:237981 56/105 (53%)
TPH 1066..1435 CDD:290579 113/532 (21%)
IQ 1689..1711 CDD:197470 7/21 (33%)
aspmXP_005161794.1 ASH 35..132 CDD:292408 24/97 (25%)
CH 965..1053 CDD:214479 47/87 (54%)
CH 1113..1252 CDD:278723 2/138 (1%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170579311
Domainoid 1 1.000 45 1.000 Domainoid score I12206
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 539 1.000 Inparanoid score I1151
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17411at33208
OrthoFinder 1 1.000 - - FOG0005407
OrthoInspector 1 1.000 - - otm26289
orthoMCL 1 0.900 - - OOG6_104698
Panther 1 1.100 - - LDO PTHR22706
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4974
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.900

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