DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asp and MICAL-like

DIOPT Version :9

Sequence 1:	NP_524488.3	Gene:	asp / 42946	FlyBaseID:	FBgn0000140	Length:	1954	Species:	Drosophila melanogaster
Sequence 2:	NP_648621.1	Gene:	MICAL-like / 39475	FlyBaseID:	FBgn0036333	Length:	1010	Species:	Drosophila melanogaster

Alignment Length:	924	Identity:	179/924 - (19%)
Similarity:	319/924 - (34%)	Gaps:	305/924 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 HPPPQAPLVEKNVYKTPQEEPVYISPQPRS-----------LKENL------------------S 233
            ||.|:.||.|::   .|.::.::|...||.           |.|.:                  |
  Fly   121 HPKPEEPLGEES---EPPQKVMHIVGMPRRDKCQKCNLPVFLAERVLVGKRAYHRTCLKCARCSS 182

  Fly   234 PMTPGNLLDV-IDNLRFTPLTETRGKGQATIFPDNLAAWPTPTLKGNVKSC---ANDMRPRRITP 294
            .:|||:..:. ::|:.   ..||....::....|.|....|.|...|.|..   ::|........
  Fly   183 LLTPGSFYETEVNNIY---CCETCPDEESEPESDILKLKTTTTDSPNDKQMVAQSSDYSEAEDKQ 244

  Fly   295 DDLED------------QPATNKTFDVKHSE-TIN-----------ISLDTLDCSRIDGQPHTPL 335
            :||||            ||.:||  |.:::| |||           ||...||  ..||......
  Fly   245 EDLEDNDIRTTDKPENFQPPSNK--DEQNNELTINPVNPILSEERKISFIPLD--EEDGGLIEQY 305

  Fly   336 NKTTTIVHATHTRALACIHEEEGPSPPRTPTKSAI-------------HDL----KRDI---KLV 380
            ||:||.|.               |:.|..|..|.:             :||    :.||   ||.
  Fly   306 NKSTTPVK---------------PAIPEKPKVSTLPLDDEQHAGVEQNNDLAVSPENDIPKEKLK 355

  Fly   381 GSPLRKY------------------SESMKDLS-LLSPQTKYAIQGSMPNLN-------EMKIRS 419
            .|.:..|                  .|::.:.| .|.|:::   :..:|..|       |..|..
  Fly   356 ISSVSIYLEDDRLVVDAIHPDNLDKQEALNNTSDALIPESQ---EAPIPENNTQVAIKPEDHISP 417

  Fly   420 IEQNRYY----------------------QEQQIQIKA------KDLNSSSSSEASLAGQQEFLF 456
            .::|:.:                      :::.|:.||      :|||.....::| .|...|..
  Fly   418 RKENKIFSNTESCSKQEGVLPKQMDLESPKDKVIETKASETDYPEDLNPFKDDDSS-KGANPFDS 481

  Fly   457 NHSE------ILAQSSRFNL-------HEVGRKSVKGSPVKNPHK--RRSH-----------ELS 495
            :..|      |.||.|:..:       .::|..|: .:|.:.||.  ..||           .:|
  Fly   482 SDDEVELLKAIPAQQSKGKVVPPRPPPPKIGLSSI-SNPSEKPHSSPTLSHGKKMPMPTPRISIS 545

  Fly   496 FSDAPSNESLYRNETVAISPPKKQRVED-TTLPRSAAPANASARSSSAH-------AWPHAQSKK 552
            .:..|:....::.:..:||....:.:.. .|..|.|....:|....||:       |...:..:.
  Fly   546 KTQTPAKPMTHQGQKSSISSSSSEHLNSIRTFDRGADDRGSSISLPSANGPRKPLRASVGSPLRS 610

  Fly   553 FKLAQTMSLMKKPATPRKVRDTSIQPSVKLYDSELYMQTCINPDP-FAATTTIDPFLASTMYLDE 616
            .:.:.|.||....:..||.|...:.|          :||..:.|| |:..:            ||
  Fly   611 EESSPTTSLSSITSPMRKKRQAPLPP----------IQTDFDSDPGFSKLS------------DE 653

  Fly   617 QAVDRHQ-------ADFKKWL----NALVSIPADLDADLNNKIDVGKLFNEVR--NKELVVAPTK 668
            |....|.       .|..:.|    .:|:|..|...::.:..:.......||.  .:.::|.||:
  Fly   654 QKALLHTQLKAPNLGDSTRRLIPLDQSLLSDEATESSNYDESLSTSNADEEVNVVYRRILVPPTQ 718

  Fly   669 EEQSMNYLTKYRLETLRKAAVELFFSEQMRLPCSKVAVY--VNKQALRIRSDRNLH--------- 722
            .|           .|:.::      .|..:.|    .||  .::....:..:::.|
  Fly   719 PE-----------NTVERS------KEDQKSP----IVYNDFDRNVSPLGHNKSTHGKWKRRKGP 762

  Fly   723 --LDVVMQRTILELLLCFNPLW-LRLGLEVVFGEKIQMQSNRDIVGLSTFILNRLFRNKCEEQRY 784
              ...:..|.:|:.|    ||. :|...|::..:::.::..    |:   ||.::.|::||.
  Fly   763 APAVPIPPRKVLQRL----PLQEIRHEFEIIAVQQLGLEKQ----GV---ILEKMIRDRCER--- 813

  Fly   785 SKAYTLTE--EYAETIKKHSLQKILFLLLFLDQAKQKRIVKHNPCLFVKKSPHKETKDILLRFSS 847
            |...|.|:  |.||.:......:.|.|.||       .:|.....||     .::.:.:.||...
  Fly   814 SLDATDTDGPESAEVLTNSKEVEDLILQLF-------ELVNEKNELF-----RRQAELMYLRRQH 866

  Fly   848 ELLANIGDITRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDGVRLTRVMEVILLRDDLTRQLR 912
            .|.....||..|:|.|....:|.:|..|:           ..:.|.:.|:::|:.:|:::...|.
  Fly   867 RLEQEQADIEHEIRVLMGQPEHNKTDSDK-----------AHEEVLINRLVKVVEMRNEVIDSLE 920

  Fly   913 VPAISRLQRIFNVK 926
            ...:...:...::|
  Fly   921 TDRVREAREDMSIK 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asp	NP_524488.3	ASH	26..122	CDD:292408
		CH	866..968	CDD:237981	9/61 (15%)
		TPH	1066..1435	CDD:290579
		IQ	1689..1711	CDD:197470
MICAL-like	NP_648621.1	CH	14..111	CDD:278723
		LIM_like_1	146..207	CDD:188784	10/63 (16%)
		DUF3585	778..933	CDD:288945	39/187 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930