DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment asp and Ehbp1

DIOPT Version :9

Sequence 1:	NP_524488.3	Gene:	asp / 42946	FlyBaseID:	FBgn0000140	Length:	1954	Species:	Drosophila melanogaster
Sequence 2:	NP_995865.2	Gene:	Ehbp1 / 36912	FlyBaseID:	FBgn0034180	Length:	1141	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	189/1002 - (18%)
Similarity:	323/1002 - (32%)	Gaps:	321/1002 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QVRVLNPSDDDIEVKVMK-----AIREEHNLSLEWMEHTVPARDEVSMELVWSPVLEVACKETLQ 111
            |..:.:|.    |||..|     ::|.:.|...:.|..:.|....|:.:
  Fly   293 QTPIKSPD----EVKQPKQTPVESLRSKTNEDFDKMVTSTPLEPNVNKD---------------- 337

  Fly   112 LIDNRNFRKEVMIILKSKSNQPVKNPRKFPTVGKTLQLKSPTGAGKTMKSVVSAAVQQKKRMSAA 176
              |.:..:|..:...:.:..|.::.........||:      |...|.|.......|..|..|:.
  Fly   338 --DVKPKKKRALFFTEKEDEQDLRVESVKEDTTKTI------GDNSTTKEKPKEESQSSKDASSV 394

  Fly   177 AAPPSKQTWRVTAPSRPAAWAHPPPQAPLVEKNVY---KTPQEEPVYIS----------PQPRSL 228
            ..|.:|:                |...||..|..|   :||:..||..|          ....||
  Fly   395 VVPSAKR----------------PELQPLNLKKSYEPSQTPESAPVPASVINESIGSCFSTSGSL 443

  Fly   229 KENLSPM--------TPGNLLDVID----------NLRFTPLTETRGKGQA------TIFPD--N 267
            ..:|.|:        |||.  |:::          |::.|.||.:...|.|      ...|:  :
  Fly   444 NNSLKPVEKIVLKENTPGQ--DLLEWCKEVTKDYPNVKVTNLTTSWRNGMAFCAIIHHFVPELID 506

  Fly   268 LAAWPTPTLKGNVK---SCANDMR-PRRITPDDLE-----DQPA------------TNKTFDVKH 311
            ::......:.||.:   ..|..:. ||.|.|.|:.     |:.|            |.|...:
  Fly   507 MSKLSAHDVVGNCRIGFDAAESLGIPRVIEPRDMNMLTVPDKLAVMTYLHQLRAHFTGKQLKI-- 569

  Fly   312 SETINISLDTLDCSRIDGQPHTPLNKTTTIVHATHTRALACIH--------------EEEGPSPP 362
             |.|..:.|  :.|.:.|. :...|.:...::.:|.::| .:|              |:..|:..
  Fly   570 -EQIGSTAD--ESSYVIGD-YKSDNLSQNRINFSHPKSL-LLHQNSFDEEINGSNKSEQLSPTSK 629

  Fly   363 RTPTKSAIHDLKRDIKLVGSPLR-----KYSESMKDLSLLS-----PQTKYAIQGSMPNLNE-MK 416
            :......:::.|..:..|.||.:     ..|:......:||     ||.:...:||.|...| ..
  Fly   630 KDVKNLILYNSKNILDKVLSPTKDKNSINASQHANQSPMLSCQTTPPQDESLDKGSQPGGKENSS 694

  Fly   417 IRSIEQNRYYQEQQ-----------IQIKAKDLNSSSSS-----EASLA----GQQEFLFNHSEI 461
            |.:|:.....:|:|           ::.:.|...|..|.     |.:::    |.:||...|::
  Fly   695 ITTIDPQAASEERQQRLLEQARRLILETRVKSGGSIESPTRPKLERTISPIHNGAEEFYAEHAK- 758

  Fly   462 LAQSSRFNLHEVGRKSVKGSPVK------------NP-HKRRSHELSFSDAPSNESLYRNETVAI 513
                 :..|.|.|..|.:.|..|            :| |::|..:||:.|: ..|:|.| |..||
  Fly   759 -----KLELKEPGSPSHRLSDPKVLQSFNAIVERVSPKHEKRGDKLSYIDS-ELEALER-EQEAI 816

  Fly   514 SPPKKQRVEDTTLPRSAAPAN---ASARSSS------AHAWPHAQSKKFKL--AQTMSLMKKPA- 566
            ..................|:|   ..||:|:      .::.......:.||  :...||....|
  Fly   817 DQKASNLEAKLRAVMGGNPSNNRRGGARNSNPFLRLIRNSIGGGDVIRIKLLDSDDESLFGGGAG 881

  Fly   567 ---------TPRKVRDTSIQPSVKLYDSELYMQTCINPDPFAATTTIDPFLASTMYLDEQAVDRH 622
                     :....|||| ..||.....||:  |.:.|.|.:.:..::....||:.........|
  Fly   882 SGGGRSGACSEDDDRDTS-SDSVCNSGDELH--TRLRPRPRSHSCFVNKNHQSTINTPAHLRPHH 943

  Fly   623 QADFKKWLNALVSIPADLDADLNNKIDVGKLFNEVRNKELVVAPTKEEQSMNYLTKYRLETLRKA 687
            ......:.:.|.|.|:.|                          :.::.|.:
  Fly   944 VHHVVPYTHMLDSSPSAL--------------------------SSQQSSCD------------- 969

  Fly   688 AVELFFSEQMRLP-CSK----VAVYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGL 747
                      .|| ||.    :||..|.:|..:|..::.|.. ..||......||..|
  Fly   970 ----------NLPACSDDDEVLAVAANGRAASLRRQQDRHRR-RRQRRERRSHLCHTP------- 1016

  Fly   748 EVVFGEKIQMQSNRDIVGLSTFILNRLFRNKCEEQRYSKAYTLTEEYAETIKKHSLQKILFLLLF 812
                                    |.....:.|||..|:.:||..      ||::|.:....|..
  Fly  1017 ------------------------NHCETEETEEQLLSQWFTLVN------KKNALLRRQMQLNI 1051

  Fly   813 LDQAK--QKRIVKHNPCLFVKKSPHKETKDILLRFSSELLANIGDITRELRRLGYVLQHRQTFLD 875
            |:|.|  :::....|..|...:|.....|.              ::.||..||  :|:...|.:|
  Fly  1052 LEQEKDLERKYTMLNQELRAAQSVEDWRKT--------------EVQREKERL--LLEELMTIVD 1100

  Fly   876 EFDYA---FNNLAVDLRDGVRLTRVME 899
            :.|..   .:|..:.:.|...:.|.:|
  Fly  1101 KRDQLVQHLHNQEIAIEDDQEIARKLE 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
asp	NP_524488.3	ASH	26..122	CDD:292408	13/74 (18%)
		CH	866..968	CDD:237981	8/37 (22%)
		TPH	1066..1435	CDD:290579
		IQ	1689..1711	CDD:197470
Ehbp1	NP_995865.2	NT-C2	12..165	CDD:287345
		CH	460..562	CDD:237981	20/103 (19%)
		DUF3585	<1027..1122	CDD:288945	25/116 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930