Protein Alignment asp and Aspm

DIOPT Version :9

• Sequence 1: NP_524488.3
• Gene: asp / 42946
• FlyBaseID: FBgn0000140
• Length: 1954
• Species: Drosophila melanogaster
• Sequence 2: NP_001099425.2
• Gene: Aspm / 289054
• RGDID: 1307111
• Length: 3133
• Species: Rattus norvegicus
• Alignment Length: 2552
• Identity: 582/2552 - (22%)
• Similarity: 966/2552 - (37%)
• Gaps: 859/2552 - (33%)

  Fly     2 SAFEITVTPSRLKQKKRAEGREPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDD--DIE 64
            :|:....:..|.::...||...|.|::::.|.|...:.|.||.:..:..|.:.:.||..:  .:|
  Rat     6 AAYSSEESGRRARRDPAAEDASPPVLLLSHFCAVPFLCFGDVRVGTSRTRSLVLHNPHAEPLHVE 70

  Fly    65 VKVMKAIREEHNLSLEWMEHTVPARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSK 129
            :.:::|..:..:.|....|  :..::::::.:.|:|:.|...:|.:..:.| :|.|...::|.:.
  Rat    71 LSLLRAAGQGFSASPNRCE--LQPKEKITISVTWTPLKEGGVREIVTFLVN-DFLKHQAVLLGNA 132

  Fly   130 SNQPVK------NPRKFPTVGKTLQLKSPTGAGKTMKSVVSAAVQQKKRMSAAAAPPSKQTWRVT 188
            ..|..|      ..:|.|...|..:..|     |......|..:.||             ..|:.
  Rat   133 EEQRKKKRSLWNTSKKIPASSKYTKRTS-----KNQNFNESFTISQK-------------VDRIR 179

  Fly   189 APSRPAAWAHPPPQAPLVEKNVYKTPQEEPVYISPQPRSLKENLSPMTPGNLLDVIDNLRFTPLT 253
            :|.:|.             :|:..:....|...|..|  |:||..|.:           ..:|:.
  Rat   180 SPLQPC-------------ENLAMSECCSPTENSSLP--LEENKVPTS-----------SISPIR 218

  Fly   254 ETRGKGQATIFPDNLAAWPTPTLKGNVKSCANDMRPRRITPDDLE-----DQPATNKTF----DV 309
            |.:.:...::|.      |.||...::....| .|..::....:.     ::..||:||    .|
  Rat   219 ECQSEACLSLFS------PGPTAYSSLHESEN-ARNSKVQDASISKNFDFNEEVTNETFINPISV 276

  Fly   310 K-HSETINISLDTLDCSRIDGQPHTPLNKTTTIVH-----------ATHTRALACIHEEEGPSPP 362
            . |||..:....|.:||       :|||...|.:|           .|....|..:......:..
  Rat   277 SHHSEGDSKLALTPNCS-------SPLNIAQTQMHFLSPDSFENDSYTSDNGLRSMKNVLSDTFK 334

  Fly   363 RTPTKS------AIHD-----------------LKRDIKL-------------------VG---- 381
            :.|::|      .:|:                 ||:.:.|                   ||
  Rat   335 KDPSESVCLESQTVHEVCQTILSPESFLNDNYGLKKGLNLESVNPVLSPTQFVKDNMVHVGQQMG 399

  Fly   382 --SPL-------RKYSESMKDLSLLSPQTKYA----IQGSMPNLNEMKIRSIEQNRYYQEQQIQI 433
              |||       |:.:|.:.|    :|:.::|    .:....|..||.:    .|..:.:|:.:|
  Rat   400 ELSPLPAKPSQDRRVNEGLAD----NPKGQHAQTPSSKSEQQNPGEMNL----HNYGFTKQKPKI 456

  Fly   434 KAKDLNSSSSSEASLAGQQEFLFNHSEILA--------QSSRFNLHEVGRKSVK----------G 480
                    |..:.:...|.:.|.....||:        .::|..|.|:.:.:.|          |
  Rat   457 --------SELQDAFCNQSKQLKKRRPILSATVTKRKPTNAREKLPEINKPNAKRSLEGVVGECG 513

  Fly   481 SPVKNPHKRRSHELSFSDAPSNESL------YRNE----TVAISPPKKQ--RVEDTT-------- 525
            ..|....::..|    |..|..|::      ||||    ||.|:..:|.  .|.||:
  Rat   514 KEVDKLKEKAFH----SSLPVVEAVINKPPSYRNEVTPSTVVIARKRKSSGTVGDTSGKLAVAEW 574

  Fly   526 -----------LPRSAAPANASARSSSAHAW-----PHAQSKKFKLAQTMSLMKKPATPRKVRDT 574
                       .|..:.|:.. ||::...|.     .:.:....|.....|::|.|.:..|.:..
  Rat   575 MDVCEIKRIHFSPLESTPSTV-ARTTKKEALTSNRISNLERSGLKKKTDSSILKTPLSKTKRKRR 638

  Fly   575 SIQPSVKLYDSELYMQTCINPDPFAATTTIDPFLASTMYLDEQAVDRHQADFKKWLNALVSIPAD 639
            ||.|   :..|.|   |.|.|...|......||.|..|:.||:..::.:..|..|||.::: |.|
  Rat   639 SIVP---VAQSHL---TFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNYILT-PDD 696

  Fly   640 LDADLN-NKIDVGKLFNEVRNKELV---VAPTKEEQSMN-YLTKYRLETLRKAAVELFFSEQMRL 699
            .....| :|::...|......:..|   .||||||.|:. |....||..||:.|..||.||:|..
  Rat   697 FTVKTNVSKVNAATLILGAEGQHKVSVPKAPTKEEVSLRAYTASCRLNRLRRTACSLFTSEKMVK 761

  Fly   700 PCSKVAVYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGLEVVFGEKIQMQSNRDIV 764
            ...|:.:.:....|.:|.||:|..|:..::.:|..||.:||||||:|||.||||.|.:..|.||.
  Rat   762 AIKKIEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPLADNSDIT 826

  Fly   765 GLSTFILNRLFRNK--CEEQRYSKAYTLTEE-YAETIKKHSLQKILFLLLFLDQAKQKRIVKHNP 826
            ||:.||||||..|.  ..|.|:.....|..: :...:.|.:|:|:|.|:.|||.||..|::.|:|
  Rat   827 GLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKISRLIDHDP 891

  Fly   827 CLFVKKSPHKETKDILLRFSSELLANIGDITRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDG 891
            |||.|.:..|.:|::||.||.:.|:..||::|.|..||..:.|.||.|||||:|..||||||:.|
  Rat   892 CLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSLLGLPVSHVQTPLDEFDFAVTNLAVDLQCG 956

  Fly   892 VRLTRVMEVILLRDDLTRQLRVPAISRLQRIFNVKLALGALGEANFQL----GGDIAAQDIVDGH 952
            |||.|.:|::....:|:.:||:|||||:|::.||.|.|..|......|    |..|.::||||.|
  Rat   957 VRLVRTIELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVSLTDEHGNTILSKDIVDRH 1021

  Fly   953 REKTLSLLWQLIYKFR---------------------------------SP-------------- 970
            |||||.|||::.:.|:                                 ||
  Rat  1022 REKTLGLLWKIAFAFQVDISLNLNQLKEEIDFLKHTHNIKTAMSALICSSPAVTKKQKDRRFSGN 1086

  Fly   971 ----------------------------------------------------------------- 970
                                                                             
  Rat  1087 FEHYGDSVKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPGYVPFDAICQRTTQSVA 1151

  Fly   971 ---------------------------------------------KFH----------------- 973
                                                         .||
  Rat  1152 CTQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLGGIPAMIH 1216

  Fly   974 --------------------------------AAATVLQKWWRRH-------------------- 986
                                            .||.::|..||::
  Rat  1217 HADMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQITWRKYKLKRDLKDRQERDKAARIIQ 1281

  Fly   987 -------------------------WLHVVIQRR---IRHKELMRRHRA-ATVIQAVFRGHQMRK 1022
                                     |..|..||:   :::::|.:.|.| |::|||.:|.|..||
  Rat  1282 AVVLNFLTRRRLQKRVSAALVIQTCWRRVSAQRKLLMLKNEKLAKLHSASASLIQAHWRRHSTRK 1346

  Fly  1023 YVKLFKTERTQAAIILQKFTRRYLAQKQLYQSYH-SIITIQRWWRAQQLGRQHRQRFVELREAAI 1086
            :....|    ..::|||...|..:|... |:.|. :.:||||.|||....::.:|||.:|:.|::
  Rat  1347 HFLKLK----HCSVILQSRLRMKIALTS-YKRYRWATVTIQRRWRAHLSRKRDQQRFRKLKSASL 1406

  Fly  1087 FLQRIWRRRLFAKKLLAAAETARLQRS--------QKQQAAASYIQMQWRSY------------- 1130
            .:|.::||....|..|.......|||:        |.::.||..||..:|.:
  Rat  1407 VIQSVFRRWKRRKLQLQTKAAVTLQRAFREWRCRKQTRERAAVVIQSWYRMHRELQKYIYIRSCV 1471

  Fly  1131 ---------------------------------QLGRIQRQQFLRQRDLIMFVQ--------RR- 1153
                                             |:|::.|..:|::|...:.:|        ||
  Rat  1472 VVIQRRVRCFHAQKLCKRRKDAVLTLQKHFRARQMGKLARTDYLQKRAAAIQLQAAFRGMKARRS 1536

  Fly  1154 ----------MRSKWSML-----------------------EQRKEFQQLKRAAINIQQRWRAKL 1185
                      ::|.|.|.                       :|.:::|::|:||:.||..:||.:
  Rat  1537 YRLQIQAACVLQSYWRMRQGRVKFLNLKKTVIKLQAHIRKHQQLQKYQKIKKAAVTIQTHFRASI 1601

  Fly  1186 SMRKCNADYLALRSSVLKVQ-AYR------------------KATIQMRIDRNHYYSLRKNVICL 1231
            |.||..|.|...||||:.:| |||                  ::..:..|.|..:.|||...:
  Rat  1602 SARKSLASYQKTRSSVIVLQSAYRGMQARKTFRRALTSVVKIQSCYRAYISRKKFRSLRNAAV-- 1664

  Fly  1232 QQRLRAIMKMREQRENYLRLRNASILVQKRYR--MRQQMIQDRNAYLRT----RKCIINVQRRWR 1290
              :|::|:||::.|:.||::|.|::.:|:.||  .|::.:|.|.|.::.    |.|::..|.|.:
  Rat  1665 --KLQSIVKMKQSRKQYLQVRAAAVFIQRWYRSQKRKESVQVREACIKLQSYFRGCLVRKQMRLQ 1727

  Fly  1291 A----TLQ----MRRERKNYLHLQTTTKRIQIKFRAKREMKKQRAEFLQLKKVTLVVQ---KRRR 1344
            :    :||    |.|.|:.||..:.....||..:.|.|....||..|||:|...:.:|   :.||
  Rat  1728 SKAAISLQSYFRMWRVRQRYLKTRKAALVIQTFYSAYRAQVHQRKIFLQVKGAAVCLQAAYRGRR 1792

  Fly  1345 ALLQMRK----------------ERQEYLHLREVTIKLQRRFHAQKSMRFMRAKYRGTQAAV--- 1390
            |..|:::                :|.:|..:.:..:|:||.:.|.|....||..:..|:.||
  Rat  1793 ARRQIKQQSTAAVTIQRVFRGHSQRMKYQTVLQSAVKVQRWYRAHKVASDMRIHFLKTREAVVVL 1857

  Fly  1391 --SC-----------------------------------------LQMHWRNHLLRKRERNSFLQ 1412
              :|                                         :|.|.|.....:|:.:.:::
  Rat  1858 QSACRGWQVRQQLRRQHQAAVKIQAAFRMARAQRQYKLVRNAAVVIQQHVRARAAGERQHSEYIR 1922

  Fly  1413 LRQAAITLQRRYRARL-------------------NMIKQLKSYAQLKQAAITIQTRYRAKKAMQ 1458
            ||.||:..|..::.::                   .|..|.:.::.:|.||..||..|||.:..:
  Rat  1923 LRHAALVFQATWKGKMLRREIAQRHQCAALIQSYYRMYSQRRKWSLMKTAARQIQVCYRAYRVGK 1987

  Fly  1459 KQVVLYQKQREAIIKVQRRYRGNLEMRKQI--------------EVYQKQ------RQAVIRLQK 1503
            :|..||.|.:.|::.:|..||| ::.|:||              ..|:.|      |.:.|.:|:
  Rat  1988 EQRHLYLKTKAAVVILQSAYRG-MKARRQITECHKAAVTIQSKFRAYRTQKKYTTCRTSAIIIQR 2051

  Fly  1504 WWRSIRDMRLCKAGYRRIRLSSLSIQRKWRATVQARR---------------------------- 1540
            |:|:|:.....:..|..::.::..:|..:|. :|.||
  Rat  2052 WYRNIKITTQQREAYLTLKRAATKVQAVYRG-IQVRRHIQHMYMAATLIKALFKIQQSRAAAVIQ 2115

  Fly  1541 -----------QREIFLSTIRKVRLMQAFIR--------------ATLLM-----RQQRREFEMK 1575
                       |:|.:|:|:|.::.:||.:|              |||:.     .:||..|...
  Rat  2116 VRYRAYYLGKIQQEKYLTTLRAIKTLQAGVRGARVRKTLRKMHFAATLIQSYFRRHRQRTYFHRL 2180

  Fly  1576 RRAAVVIQRRFRARCAMLKARQDYQLIQSSVILVQRKFR---ANRSMKQ---------------- 1621
            |:||.|:|:|:||........|.|..::.||||||..||   |.|.:|.
  Rat  2181 RKAATVVQQRYRAVKEGSSQFQRYSRLRRSVILVQAAFRGLKARRHLKAMHLAATVIQRRFRTLL 2245

  Fly  1622 ARQEFVQLRTIAVHLQQKFRGKRLMIEQRNCFQ--LLRCSMPGFQARARGFMARKRFQAL----- 1679
            .|::|:.||...:.:|:::|.:   :..:.|.|  ||..::...|:..:|:|.||..|.:
  Rat  2246 MRRKFLSLRKTVIWIQRQYRAR---LHAKYCRQQLLLEKAVTKIQSSYKGWMVRKSVQKMHRAAT 2307

  Fly  1680 -------MTPEMMDLIRQKRAAKVIQRYWRGYLIRRRQKHQGLLDIRKRIAQLRQEA-----KAV 1732
                   |....:...|.|||:.|||:.:|.:   |..:.|..|.:|:|.|.|..:|     ||.
  Rat  2308 VIQATFRMHRACVRYQRLKRASVVIQKQYRAH---RTAELQRQLFVRQRQAALTLQAAFRGVKAR 2369

  Fly  1733 NSVRCKVQEA--------VRFLRGRFIASDALAV-LSRLDRLSRTVPHLLMWCSEFMSTFCYGIM 1788
            |.::.....|        .|.:|.:|:|....|: :.|..|.:....|.|   .:|:......|.
  Rat  2370 NHLKTMHASATLIQSKFRARIVRRQFLALRKAAIFVQRKYRATLYAKHKL---HQFLQLRKAAIT 2431

  Fly  1789 AQAI--RSEVDKQLIER 1803
            .|:.  |..|.|||.||
  Rat  2432 IQSSFRRLMVKKQLQER 2448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
asp	NP_524488.3	ASH	26..122	CDD:292408	20/97 (21%)
		CH	866..968	CDD:237981	51/105 (49%)
		TPH	1066..1435	CDD:290579	125/581 (22%)
		IQ	1689..1711	CDD:197470	9/21 (43%)
Aspm	NP_001099425.2	ASH	29..126	CDD:292408	20/99 (20%)
		CH	941..1037	CDD:294029	46/95 (48%)
		CH	1095..>1148	CDD:278723	0/52 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0165
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17411at33208
OrthoFinder	1	1.000	-	-		FOG0005407
OrthoInspector	1	1.000	-	-		oto96362
orthoMCL	1	0.900	-	-		OOG6_104698
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650