DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment asp and ASPM

DIOPT Version :9

Sequence 1:NP_524488.3 Gene:asp / 42946 FlyBaseID:FBgn0000140 Length:1954 Species:Drosophila melanogaster
Sequence 2:NP_060606.3 Gene:ASPM / 259266 HGNCID:19048 Length:3477 Species:Homo sapiens


Alignment Length:2188 Identity:494/2188 - (22%)
Similarity:875/2188 - (39%) Gaps:640/2188 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 EGREPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDDDIEVKVMKAIREEHNLSLEWMEH 84
            |...|.|:.::.|.....:.|.||.:..:....:.:.||:::..|||:......:...|:.....
Human    32 EASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCF 96

  Fly    85 TVPARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSKSNQPVKNPRKFPTVGKTLQL 149
            .:..::::.:.:.|:|:.|...:|.:..:.| :..|...|:|.:...|..|....:.|:      
Human    97 VLQPKEKIVISVNWTPLKEGRVREIMTFLVN-DVLKHQAILLGNAEEQKKKKRSLWDTI------ 154

  Fly   150 KSPTGAGKTMKSVVSAAVQQKKRMS-----AAAAPPSKQTWRVTAPSRPAAWAHPPPQAPLVEKN 209
                     .|..:||:....:|:|     ......|::..||.:|.:...........|..|.|
Human   155 ---------KKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENN 210

  Fly   210 VYKTPQEEPVYISP-------------QPRSLK-----ENLSPMTPGNLLDV----IDNLRFT-- 250
            .. ..:|..:.|||             .|.|::     .:|.......||:|    :..:.|.  
Human   211 SL-ILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEK 274

  Fly   251 PLTET----------RGKGQATIFPDNLAAWPTPTLKGNVKSCAN--DMRPRRITPDDLEDQPAT 303
            .:|||          ||:....            :|..|..|..|  ..:...::||..      
Human   275 AVTETSFNSVNVNGQRGENSKL------------SLTPNCSSTLNITQSQIHFLSPDSF------ 321

  Fly   304 NKTFDVKHSETINISLDTLDCSRID---GQPHTPLNKTTTIVHATHTRALACIHEEEGPSPPRTP 365
                 |.:|...|..|:.:.|...|   .....|::..:||.|..:.:.|         ||    
Human   322 -----VNNSHGANNELELVTCLSSDMFMKDNSQPVHLESTIAHEIYQKIL---------SP---- 368

  Fly   366 TKSAIHD---LKRDIKLVG-SPLRKYSESMKDLSLLSPQTKYAIQGSMPNLNEMKIRSIEQNRYY 426
             .|.|.|   |.:|::... :|:...::.:||.......::...:..:.|.|....:|.|.   :
Human   369 -DSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPED---W 429

  Fly   427 QEQQIQIKAKDLNSSSSSEASLAGQQEFLFNHSEILAQSS-RFN-LHEVGRKSVKGSPVKNP--- 486
            ::.::..:..:...|.|.:|......|...|:...:.|:: :|: :.::...|....|.:.|   
Human   430 RKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILS 494

  Fly   487 ---HKRRS-------------------------HELSFSDAPSNESL----------------YR 507
               .||::                         ||...::....|..                |:
Human   495 ATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYK 559

  Fly   508 NE------TVAISPPKKQ--RVEDTTLPRSAAPANASARS-SSAHAWPHAQ-------------- 549
            ||      |.:::..:|.  .:||..: |.|...:...|. ...|..|...              
Human   560 NEVTPSSTTASVARKRKSDGSMEDANV-RVAITEHTEVREIKRIHFSPSEPKTSAVKKTKNVTTP 623

  Fly   550 -SKKFKLAQTMSLMKKP-----ATPRKVRDTSIQPSVKLYDSELYMQTCINPDPFAATTTID--- 605
             ||:....:.::|.||.     .||....:...:|.:.:..|.|   |.|.|    ..|.|.   
Human   624 ISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSSL---TFIKP----LKTDIPRHP 681

  Fly   606 -PFLASTMYLDEQAVDRHQADFKKWLNALVSIPADLDADLN-NKIDVGKLFNEVRNKELVV---A 665
             ||.|..|:.||:..::.:..|..|||.::: |.|.....| ::::...|...:.|:..:.   |
Human   682 MPFAAKNMFYDERWKEKQEQGFTWWLNFILT-PDDFTVKTNISEVNAATLLLGIENQHKISVPRA 745

  Fly   666 PTKEEQSMN-YLTKYRLETLRKAAVELFFSEQMRLPCSKVAVYVNKQALRIRSDRNLHLDVVMQR 729
            |||||.|:. |..:.||..||:||..||.||:|.....|:.:.:..:.|.:|.||:|..||..::
Human   746 PTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQ 810

  Fly   730 TILELLLCFNPLWLRLGLEVVFGEKIQMQSNRDIVGLSTFILNRLFRN---KCEEQRYSKAYTLT 791
            .:|..||.:||||||:|||..:||.|.::.|.|:.||:.||||||..|   ..|.:..:..:...
Human   811 KVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYR 875

  Fly   792 EEYAETIKKHSLQKILFLLLFLDQAKQKRIVKHNPCLFVKKSPHKETKDILLRFSSELLANIGDI 856
            :.:.|.:.|.:|:|:|.|:.|||.||..|::.|:||||.|.:..|.:|:|||.||.:.|:..||:
Human   876 DGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDL 940

  Fly   857 TRELRRLGYVLQHRQTFLDEFDYAFNNLAVDLRDGVRLTRVMEVILLRDDLTRQLRVPAISRLQR 921
            :|.|..||..:.|.||..||||:|..||||||:.||||.|.||::....||:::||:|||||||:
Human   941 SRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQK 1005

  Fly   922 IFNVKLALGALGEANFQL----GGDIAAQDIVDGHREKTLSLLWQLIYKFR-------------- 968
            :.||.:.|..|.....:|    |..|.::||||.||||||.|||::.:.|:              
Human  1006 MHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEI 1070

  Fly   969 ----------------------------------------------------------------- 968
                                                                             
Human  1071 AFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFT 1135

  Fly   969 ----------------------------------------------------------------- 968
                                                                             
Human  1136 VSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHE 1200

  Fly   969 -------------SPKFH----------------------------------------------- 973
                         ...||                                               
Human  1201 NTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRK 1265

  Fly   974 --AAATVLQKWWRRHWLHVVIQRRIRHKELMRRHRAATVIQAVFRGHQMRKYVKLFKTERTQAAI 1036
              .||.::|..||::.|...::   ||:|   |.:||.:||........::.::    :|..||:
Human  1266 EIRAARLIQTTWRKYKLKTDLK---RHQE---REKAARIIQLAVINFLAKQRLR----KRVNAAL 1320

  Fly  1037 ILQKFTRRYLAQKQLYQ---------------------------------SYHSII--------- 1059
            ::||:.||.|||::|..                                 .|:|||         
Human  1321 VIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMII 1385

  Fly  1060 -------------TIQRWWRAQQLGRQHRQRFVELREAAIFLQ---RIWRRRLFAKKLLAAAETA 1108
                         ||||.|||....:|.:||:..|:.:.:.:|   |.|::|....::.|.....
Human  1386 AVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQ 1450

  Fly  1109 R------LQRSQKQQAAASYIQMQWRSYQLGRIQRQQFLRQRDLIMFVQRRMRSKWSMLEQRKEF 1167
            |      |::..|::.:|..||..:|.::    :.::::..|..::.:|:|.|    ..:.:|.:
Human  1451 RAFREWHLRKQAKEENSAIIIQSWYRMHK----ELRKYIYIRSCVVIIQKRFR----CFQAQKLY 1507

  Fly  1168 QQLKRAAINIQQRWRAKLSMRKCNADYLALRSSVLKVQA-------------YRKATI-----QM 1214
            ::.|.:.:.||:.::|.|..:....:||..|::.:::||             .|.|.:     :|
Human  1508 KRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRM 1572

  Fly  1215 RIDRNHYYSLRKNVICLQQRLRAIMKMREQRENYLRLRNASILVQKRYRMRQQMIQDRNAYLRTR 1279
            |.||..:.:|:|.:|    :.:|.::..:||:.|.:::.|::::|..:|.....::...:|.:||
Human  1573 RQDRVRFLNLKKTII----KFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTR 1633

  Fly  1280 KCIINVQRRWRATLQMRRERKNYLHLQTTTKRIQIKFRA---KRE----------------MKKQ 1325
            ..:|.:|..:|.    .:.||.|:|:.|:..:||..:||   |:|                ||:.
Human  1634 SAVIVLQSAYRG----MQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQT 1694

  Fly  1326 RAEFLQLKKVTLVVQKRRRALLQMRKERQEYLHLREVTIKLQ---RRFHAQKSMRFMRAKYRGTQ 1387
            |.::|.|:...|.:|:..|:.....::|:||:.:||..||||   |.:..:|.||..|       
Human  1695 RKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQR------- 1752

  Fly  1388 AAVSCLQMHWRNHLLRKRERNSFLQLRQAAITLQRRYRARLNMIKQLKSYAQLKQAAITIQTRYR 1452
            .||..||.::|    .::.|..:|::.:|.|.:|..|.|....:.|.|::.|:|:||..:|..||
Human  1753 KAVISLQSYFR----MRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYR 1813

  Fly  1453 AKKAMQKQVVLYQKQREAIIKVQRRYRGNLEMRKQIEVYQKQRQAVIRLQKWWRSIRDMRLCKAG 1517
            ..|..|    |.::|..|.:|:|..:||   ..|::: ||...|::|::|:|:|:.:.:...:..
Human  1814 GYKVRQ----LIKQQSIAALKIQSAFRG---YNKRVK-YQSVLQSIIKIQRWYRAYKTLHDTRTH 1870

  Fly  1518 YRRIRLSSLSIQ---RKWRATVQARRQREIFLSTIRKVRLMQAFIRATLLMRQQRREFEMKRRAA 1579
            :.:.:.:.:|:|   |.|:...|.||:.:                                  ||
Human  1871 FLKTKAAVISLQSAYRGWKVRKQIRREHQ----------------------------------AA 1901

  Fly  1580 VVIQRRFRARCAMLKARQDYQLIQSSVILVQRKFRANRSMKQARQEFVQLRTIAVHLQQKFRGK- 1643
            :.||..||    |.||::.::|.:::.:::|:.|||..:.::...|:::||...:.||..::|| 
Human  1902 LKIQSAFR----MAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHAVLVLQSMWKGKT 1962

  Fly  1644 --RLMIEQRNCFQLLRCSMPGFQARARGFMARKRFQALMTPEMMDLIRQKRAAKVIQRYWRGYLI 1706
              |.:..|..|..::       |:..|..:.:|:::.:           |:||.:||:|:|.|.|
Human  1963 LRRQLQRQHKCAIII-------QSYYRMHVQQKKWKIM-----------KKAALLIQKYYRAYSI 2009

  Fly  1707 RRRQKHQGL---------------LDIRKRIAQLRQEAKAVNS 1734
            .|.|.|..|               :.:||||....:.|..:.|
Human  2010 GREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQS 2052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aspNP_524488.3 ASH 26..122 CDD:292408 17/95 (18%)
CH 866..968 CDD:237981 52/105 (50%)
TPH 1066..1435 CDD:290579 101/417 (24%)
IQ 1689..1711 CDD:197470 10/21 (48%)
ASPMNP_060606.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
ASH 37..134 CDD:292408 17/97 (18%)
Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000250|UniProtKB:Q8CJ27 308..409 23/125 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..443 4/30 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..581 4/21 (19%)
CH 960..1056 CDD:294029 48/95 (51%)
CH 1114..>1171 CDD:278723 0/56 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145845
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0165
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 554 1.000 Inparanoid score I1121
Isobase 1 0.950 - 0 Normalized mean entropy S8171
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D17411at33208
OrthoFinder 1 1.000 - - FOG0005407
OrthoInspector 1 1.000 - - oto89238
orthoMCL 1 0.900 - - OOG6_104698
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3494
SonicParanoid 1 1.000 - - X4974
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.640

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