DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment asp and Aspm

DIOPT Version :9

Sequence 1:NP_524488.3 Gene:asp / 42946 FlyBaseID:FBgn0000140 Length:1954 Species:Drosophila melanogaster
Sequence 2:NP_033921.3 Gene:Aspm / 12316 MGIID:1334448 Length:3122 Species:Mus musculus


Alignment Length:2710 Identity:587/2710 - (21%)
Similarity:1016/2710 - (37%) Gaps:886/2710 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 RLKQKKRAEGREPAVVVMAPFSAKAIVQFEDVPITKTARRQVRVLNPSDD--DIEVKVMKAIREE 74
            |.:....|....|.|::::.|.....:.|.||.:..:..|.:.:.||.::  .:|:.:::|..:.
Mouse    16 RARPDPEAGDPSPPVLLLSHFCGVPFLCFGDVRVGTSRTRSLVLHNPHEEPLQVELSLLRAAGQG 80

  Fly    75 HNLSLEWMEHTVPARDEVSMELVWSPVLEVACKETLQLIDNRNFRKEVMIILKSKSNQPVKNPRK 139
            .:::....|  :..::::::.:.|:|:.|...:|.:..:.| :|.|...|:| ..:.:|.|..|.
Mouse    81 FSVAPNRCE--LKPKEKLTISVTWTPLREGGVREIVTFLVN-DFLKHQAILL-GNAEEPKKKKRS 141

  Fly   140 FPTVGKTLQLKSPTGAGKTMKSV------VSAAVQQKKR------------MSAAAAPPSKQTWR 186
            .....|    |.|..:..|.::.      .|..:.||.|            ||..::|...   :
Mouse   142 LWNTSK----KIPASSKHTKRTSKNQHFNESFTISQKDRIRSPLQPCENLAMSECSSPTEN---K 199

  Fly   187 VTAPS-RPAAWAHPPPQAPLV--EKNVYKTPQEEPVYISPQPRSLK-ENLSPMTPGNLLDVIDNL 247
            |..|| .|..........||.  |...|.:..|     |...::|| ::.|.....:..:.:.|.
Mouse   200 VPTPSISPIRECQSETCLPLFLRESTAYSSLHE-----SENTQNLKVQDASISQTFDFNEEVANE 259

  Fly   248 RF-TPLT---ETRGKGQATIFPDNLAAWPTPTLKGNVKSCAND--MRPRRITPDDLED-QPATNK 305
            .| .|::   ::.|..:.|:.|:  .:.|..:.:..:...:.|  :..|..:.:||:. :...:.
Mouse   260 TFINPISVCHQSEGDRKLTLAPN--CSSPLNSTQTQIHFLSPDSFVNNRYTSDNDLKSMKNVLSD 322

  Fly   306 TFDVKHSETINISLDTLD--CSRIDGQPHTPLNKTTTIVHATHTRALACIHEEEGPSPPRTPTKS 368
            ||....:|::.:...|:.  |..| ..|.:.||....:....:.:::         :|..:||:.
Mouse   323 TFRKDPAESVCLESQTVHEVCQTI-LSPDSFLNDNYGLKKGLNFKSV---------NPVLSPTQF 377

  Fly   369 AIHDLKRDIKLVGSPLRKYSESMKDLSL-----LSPQTKYAIQGSMPNLNEMKIRSIE------- 421
                :|..:..||....|.:|:.:|..:     .:|:.::|   ..|:....|...:|       
Mouse   378 ----VKDSMGHVGQQTGKSNEASQDWRINEGLAYTPECQHA---QTPSSRSEKQNPVEVKPHTYD 435

  Fly   422 -----------QNRYYQEQQIQIKAKDLNSSSSSEASLAGQQEFLFNHSEILAQSSRFNLH---- 471
                       |:.:..:.:...|.:.:.|::.::......:|.|   .||....::..|.    
Mouse   436 FTKQKPKISEFQDAFCHQSKQPHKRRPILSATVTKRKPTNAREKL---PEINKPDAKRCLEGLVG 497

  Fly   472 ----EVGRKSVKG----SPVKNP--------------------HKRRSHELSFSDAPSNESLYRN 508
                |||....||    .||..|                    .||:||. :..||  |..:...
Mouse   498 ERGKEVGSLREKGFHSSLPVVEPGVSKALSYRDEVTPATVVVARKRKSHG-TVGDA--NGKVAAE 559

  Fly   509 ETVAISPPKK------QRVEDTTLPRSAAPANASARSSSAHAWPHAQSKKFKLAQTMSLMKKPAT 567
            |.:.:...|:      :....|....:....:.|.|.||      .:....|.....|::|.|.:
Mouse   560 EWMDMCEVKRIHFSPLESTPSTVARTTKKEGHTSKRISS------LERSGLKKKMDSSILKTPLS 618

  Fly   568 PRKVRDTSIQPSVKLYDSELYMQTCINPDPFAATTTIDPFLASTMYLDEQAVDRHQADFKKWLNA 632
            ..|.:..||   |.:..|.|   |.|.|...|......||.|..|:.||:..::.:..|..|||.
Mouse   619 KTKKKRRSI---VAVAQSHL---TFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNY 677

  Fly   633 LVSIPADLDADLN-NKIDVGKLFNEVRNKELV---VAPTKEEQSMN-YLTKYRLETLRKAAVELF 692
            ::: |.|.....| :|::...|.....::..:   .||||||.|:. |....||..||:.|..||
Mouse   678 ILT-PDDFTVKTNVSKVNAASLVLGAESQHKISVPKAPTKEEVSLRAYTASCRLNRLRRTACSLF 741

  Fly   693 FSEQMRLPCSKVAVYVNKQALRIRSDRNLHLDVVMQRTILELLLCFNPLWLRLGLEVVFGEKIQM 757
            .||:|.....||.:.:....|.:|.||:|..|:..::.:|..||.:||||||:|||.||||.|.:
Mouse   742 TSEKMVKAIKKVEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPL 806

  Fly   758 QSNRDIVGLSTFILNRLFRNK--CEEQRYSKAYTLTEE-YAETIKKHSLQKILFLLLFLDQAKQK 819
            ..|.|:.||:.||||||..|.  ..|.|:.....|..: :...:.|.:|:|:|.|:.|||.||..
Mouse   807 ADNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKIS 871

  Fly   820 RIVKHNPCLFVKKSPHKETKDILLRFSSELLANIGDITRELRRLGYVLQHRQTFLDEFDYAFNNL 884
            |::.|:||||.|.:..|.:|::||.||.:.|:..||::|.|..||..:.|.||.|||||:|..||
Mouse   872 RLIDHDPCLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSFLGLPVSHVQTPLDEFDFAVTNL 936

  Fly   885 AVDLRDGVRLTRVMEVILLRDDLTRQLRVPAISRLQRIFNVKLALGALGEANFQL----GGDIAA 945
            ||||:.||||.|.:|::....:|:.:||:|||||:|::.||.|.|..|......|    |..|::
Mouse   937 AVDLQCGVRLVRTVELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVPLTDEHGSAISS 1001

  Fly   946 QDIVDGHREKTLSLLWQLIYKFR------------------------------------------ 968
            :|:||.||||||.|||::...|:                                          
Mouse  1002 KDVVDRHREKTLGLLWKIALAFQVDISLNLDQLKEEIDFLKHTHSIKRAMSALTCPSQAITNKQR 1066

  Fly   969 ----------------------------------------------------------------- 968
                                                                             
Mouse  1067 DKRISGNFERYGDSVQLLMDWVNAVCAFYNKKVENFTVSFSDGRILCYLIHHYHPCYVPFDAICQ 1131

  Fly   969 --------------------------------------SPK------------FH---------- 973
                                                  :|:            ||          
Mouse  1132 RTSQSVACAQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLG 1196

  Fly   974 ---------------------------------------AAATVLQKWWRRHWLHVVIQRRIRH- 998
                                                   .||.::|..||::.|    :|.::| 
Mouse  1197 GIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKL----KRDLKHH 1257

  Fly   999 --------------------KELMRRHRAATVIQAVFRGHQMRKYVKLFKTER-----TQAAIIL 1038
                                :.|.:...||.|||..:|....::.:::.|.|:     .::|:::
Mouse  1258 QERDKAARVIQSVVLNFLSRRRLQKNVSAALVIQKCWRRVSAQRKLRMLKNEKLAKLQNKSAVLI 1322

  Fly  1039 QKFTRRYLAQKQLYQSYH-----------------------SIITIQRWWRAQQLGRQHRQRFVE 1080
            |.:.|||..:|:..:..|                       :.:||||.|||....::.:|.|.:
Mouse  1323 QAYWRRYSTRKRFLRLKHYSVILQSRIRMKIALTSYKRYLWATVTIQRHWRAYLSRKRDQQIFRK 1387

  Fly  1081 LREAAIFLQ---RIWRRRLFAKKLLAAAETARL-----QRSQKQQAAASYIQMQWRSYQLGRIQR 1137
            |:.:::.:|   |.|:||....:..||....|.     .|.|.::.:|..||..:|.::    :.
Mouse  1388 LKSSSLVIQFMFRRWKRRKLQLQTKAAVTLQRAFREWHLRKQIRERSAVVIQSWYRMHR----EL 1448

  Fly  1138 QQFLRQRDLIMFVQRRMR----------------------------------------------- 1155
            |:::..|..::.:|||:|                                               
Mouse  1449 QKYIYIRSCVIVIQRRVRCFQAQKLYKRRKDAILTLQKHYRARQKGKLAHADYLQKRAATIRLQA 1513

  Fly  1156 ----------------------SKWSMLEQR-----------------KEFQQL------KRAAI 1175
                                  |.|.|.::|                 :::|||      |:|||
Mouse  1514 AFRGMKARHSYRLQIGAACVLQSYWRMRQERVRFLNLKKMVIKLQAHIRKYQQLQKYKKIKKAAI 1578

  Fly  1176 NIQQRWRAKLSMRKCNADYLALRSSVLKVQ----------AYRKATIQMRIDRNHY--YSLRK-- 1226
            .||..:||.:|.|:..|.|...||||:.:|          |:|.|...:...:::|  |..||  
Mouse  1579 TIQTHFRASISARRVLASYQKTRSSVIVLQSACRGMQARKAFRHALASVIKIQSYYRAYICRKTF 1643

  Fly  1227 -NVICLQQRLRAIMKMREQRENYLRLRNASILVQKRYRMRQQMIQDRNAYLRTRKCIINVQRRWR 1290
             |......:|::|:||::.|:.||::|.|::.:|:.||.::...|.|..|::.|:..|.:|..:|
Mouse  1644 QNFKNATIKLQSIVKMKQSRKQYLQIRAAALFIQRWYRSQKLASQKRKEYIQVRESCIKLQSHFR 1708

  Fly  1291 ATL-------------------QMRRERKNYLHLQTTTKRIQIKFRAKREMKKQRAEFLQLKKVT 1336
            ..|                   :||..|:.||.:......||..:.|.|....||..|||:|:..
Mouse  1709 GCLVRKQLRLQCKAAISLQSYFRMRTARQRYLKMCKAALVIQSFYCAYRAQISQRKNFLQVKRAA 1773

  Fly  1337 LVVQ------KRRRALLQM-------------RKERQEYLHLREVTIKLQRRFHAQKSMRFMRAK 1382
            :.:|      |.||.:.|.             ..:|.:|..:.:..:|:||.:.|||....||.:
Mouse  1774 ICLQAAYRGCKVRRQIKQQSTAAVTIQRVFRGHSQRMKYQTMLQSAVKIQRWYRAQKVAYDMRIQ 1838

  Fly  1383 YRGTQAAVSCLQMHWRN------------------------------HLLR-------------- 1403
            :..|:.||.|||..:|.                              .|||              
Mouse  1839 FLKTREAVVCLQSAYRGWQVRQQLRRQHEAAVKIQSTFRMAVAQQQYKLLRAAAAVIQQHVRARA 1903

  Fly  1404 --KRERNSFLQLRQAAITLQRRYRARL-------------------NMIKQLKSYAQLKQAAITI 1447
              ||:..:::|||.||:..|..::.::                   .|..|.:.::.:|.||:.|
Mouse  1904 AGKRQHLAYIQLRHAALVFQAAWKGKMLRRQIARQHQCAALIQSYYRMHIQRRKWSIMKTAALQI 1968

  Fly  1448 QTRYRAKKAMQKQVVLYQKQREAIIKVQRRYRGNLEMRKQI--------------------EVYQ 1492
            |..|||.|..::|..||.|.:.|::.:|..||| :::||::                    :.|.
Mouse  1969 QLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRG-MKVRKRVAECHKAAVTIQSKFRAYRTQKKYT 2032

  Fly  1493 KQRQAVIRLQKWWRSIR----------------------------------------------DM 1511
            ..|.:.|.:|:|:|:|:                                              .|
Mouse  2033 TYRTSAIVIQRWYRNIKITTQQHQEYLNLRRAAVQVQAAYRGIRVRRRIQHMHMAATLIEAMFKM 2097

  Fly  1512 RLCKAGYRRIRLSSLSIQRKWRATVQARRQREIFLSTIRKVRLMQAFIR--------------AT 1562
            |..:..|.::|.::|.||.::||....:.|.|.:|.|::.::.:||.:|              ||
Mouse  2098 RQSRVRYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRRTVRKMHFAAT 2162

  Fly  1563 LLM-----RQQRREFEMKRRAAVVIQRRFRARCAMLKARQDYQLIQSSVILVQRKFRANRSMKQ- 1621
            |:.     .:|:..|...|:||.::|:|:||........|.|..::.||:|:|..||..|:.:. 
Mouse  2163 LIQSHFRGHRQQTYFHRLRKAATMVQQRYRAVKEGSAEFQRYSRLRRSVLLIQAAFRGLRTRRHL 2227

  Fly  1622 ------------------ARQEFVQLRTIAVHLQQKFRGKRLMIEQRNCFQLLRCSMPGFQARAR 1668
                              .|::|:.||..|:.:|:::|. ||..:......||..::...|:..|
Mouse  2228 KAMHLAATLIQRRFRTFAMRRKFLSLRKTAIWIQRQYRA-RLYAKYSRQQLLLEKAVIKIQSSYR 2291

  Fly  1669 GFMARKRFQ------------------------------ALMTPEMMDLIRQKRAAKV------- 1696
            |::.|||.|                              .:......:|.|||.||.:       
Mouse  2292 GWVVRKRVQKMHRAATVIQATFRMHGAYMRYQHLKRASVVIQVHTAAELQRQKHAAVILQAAVRG 2356

  Fly  1697 ----------------IQRYWRGYLIRRR------------QKHQGLLDIRKRI---AQLRQEAK 1730
                            ||..:|.:::|||            :|.:..|..:.::   .|||:.|.
Mouse  2357 MKTRSHLKTMHSSATLIQSQFRAFIVRRRFIALRKAAIFVQRKFRATLYAKHKLHQFLQLRKAAI 2421

  Fly  1731 AVNS------VRCKVQEAVRFLRGRFIASDALAVLSRLDRLSRTVPHLLMW-CSEFMSTFCYGIM 1788
            .:.|      |:.|:||..|          |.|::....|:.||.....:| |:......||...
Mouse  2422 TIQSSYRRLMVQKKLQEMHR----------AAALIQATFRMHRTYVAFHIWKCASIRIQQCYRTY 2476

  Fly  1789 AQAIRSEVDKQLI--ERCSRIILNLARYNSTTVNTFQEGGLVTIAQMLLRWCDKDSEIFNTLCTL 1851
             :.|:.:.:| ||  |:.|..:|..:.|.......|.:         ..||..|          :
Mouse  2477 -RTIKLQKEK-LIREEQHSAAVLIQSTYRMYRQRCFYQ---------QRRWAAK----------V 2520

  Fly  1852 IWVFAHCPKKRKIIHDYMTNPEAIYMVRETKKLV---------ARKEKMKQNARKPPPMTSGRYK 1907
            |.......|:|:         :.:|:.:|...|:         |::.:.:..|..   :|...::
Mouse  2521 IQKTYRANKRRQ---------DLLYVCKEETPLLQMHFQGLNTAKQGRQQHGAAM---ITQKHFR 2573

  Fly  1908 SQKINFTPCSLPSLEPDF--GIIRYSPYTFISSVYAFDTILCKLQ 1950
            :    |....|...|..|  |..:|....::|.|.|    .|::|
Mouse  2574 A----FKARRLMEAERGFQAGCRKYKAKKYLSKVEA----ACRIQ 2610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aspNP_524488.3 ASH 26..122 CDD:292408 18/97 (19%)
CH 866..968 CDD:237981 50/105 (48%)
TPH 1066..1435 CDD:290579 127/586 (22%)
IQ 1689..1711 CDD:197470 11/56 (20%)
AspmNP_033921.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 2/9 (22%)
ASH 29..126 CDD:292408 18/99 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..169 5/33 (15%)
Sufficient for interaction with KATNA1:KATNB1. /evidence=ECO:0000269|PubMed:28436967 289..388 19/112 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..600 5/26 (19%)
CH 928..1024 CDD:294029 45/95 (47%)
CH 1082..>1135 CDD:278723 0/52 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835916
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0165
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8171
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005407
OrthoInspector 1 1.000 - - oto92808
orthoMCL 1 0.900 - - OOG6_104698
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3494
SonicParanoid 1 1.000 - - X4974
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.580

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